Results 11 to 20 of about 584,058 (291)

Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]

Frontiers in Neuroscience, 2013
The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn, Andrew Charles Penn, Ales eBalik, Ingo H Greger   +3 more
doaj   +3 more sources

A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita, Dario eVeneziano, Alfredo eFerro   +2 more
doaj   +3 more sources

Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]

Genome Biology, 2017
Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park, Jiguang Guo, Shihao Shen, Levon Demirdjian, Ying Nian Wu, Lan Lin, Yi Xing   +6 more
doaj   +4 more sources

The Role of RNA Editing in Cancer Development and Metabolic Disorders [PDF]

Frontiers in Endocrinology, 2018
Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung, Che-Pei Kung, Leonard B. Maggi, Leonard B. Maggi, Jason D. Weber, Jason D. Weber, Jason D. Weber   +6 more
doaj   +3 more sources

A-to-I RNA Editing Contributes to Proteomic Diversity in Cancer [PDF]

Cancer Cell, 2018
Adenosine (A) to inosine (I) RNA editing introduces many nucleotide changes in cancer transcriptomes. However, due to the complexity of post-transcriptional regulation, the contribution of RNA editing to proteomic diversity in human cancers remains unclear. Here, we performed an integrated analysis of TCGA genomic data and CPTAC proteomic data. Despite
Xinxin, Peng, Xiaoyan, Xu, Yumeng, Wang, David H, Hawke, Shuangxing, Yu, Leng, Han, Zhicheng, Zhou, Kamalika, Mojumdar, Kang Jin, Jeong, Marilyne, Labrie, Yiu Huen, Tsang, Minying, Zhang, Yiling, Lu, Patrick, Hwu, Kenneth L, Scott, Han, Liang, Gordon B, Mills   +16 more
openaire   +4 more sources

Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]

Frontiers in Genetics, 2013
RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, tRNA, rRNA, and non-coding RNAs.
Minati eSingh
doaj   +3 more sources

Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]

Frontiers in Oncology, 2020
A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and ...
Chi Zhou, Zhiting Wei, Liye Zhang, Zhaoyi Yang, Qi Liu   +4 more
doaj   +3 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +5 more sources

The cell line A-to-I RNA editing catalogue [PDF]

Nucleic Acids Research, 2020
Abstract Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory processes and diseases such as autoimmune and cardiovascular diseases as well
Eli Eisenberg, Erez Y Levanon, Ernesto Picardi, Ayal Hendel, Eli Kopel, Amos A Schaffer   +5 more
openaire   +3 more sources

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
Bjorn-Erik, Wulff, Kazuko, Nishikura
openaire   +2 more sources