Results 11 to 20 of about 515,927 (320)

The evolution and adaptation of A-to-I RNA editing

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein.
Arielle Yablonovitch, Patricia Deng, Dionna Jacobson, J. B. Li   +3 more
semanticscholar   +6 more sources

Adaptation of A-to-I RNA editing in Drosophila

PLOS Genetics, 2017
Adenosine-to-inosine (A-to-I) editing is hypothesized to facilitate adaptive evolution by expanding proteomic diversity through an epigenetic approach. However, it is challenging to provide evidences to support this hypothesis at the whole editome level.
Y. Duan, Shengqian Dou, S. Luo, Hong Zhang, Jian Lu   +4 more
semanticscholar   +6 more sources

De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]

Cancers, 2020
Simple Summary Long non-coding RNAs are emerging as key regulators of gene expression at both transcriptional and translational levels, and their alterations (in expression or sequence) are linked to tumorigenesis and tumor progression.
Domenico A Silvestris, C. Scopa, Sara Hanchi, F. Locatelli, A. Gallo   +4 more
semanticscholar   +4 more sources

RNA Editing: An I for editing [PDF]

Current Biology, 1995
In vitro editing in mammalian nuclear extracts reveals adenosine-to-inosine conversions in glutamate receptor messenger RNAs.
Brenda Bass
openalex   +5 more sources

Is abundant A-to-I RNA editing primate-specific? [PDF]

Trends in Genetics, 2004
preprint version; final version available at http://dx.doi.org/10.1016/j.tig.2004.12 ...
Eli Eisenberg, Sergey Nemzer, Yaron Kinar, Rotem Sorek, Gideon Rechavi, Erez Y. Levanon   +5 more
openalex   +4 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +5 more sources

Advances in A-to-I RNA editing in cancer. [PDF]

Mol Cancer
RNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine ...
Zhang Y, Li L, Mendoza JJ, Wang D, Yan Q, Shi L, Gong Z, Zeng Z, Chen P, Xiong W.   +9 more
europepmc   +4 more sources

Potent and Selective Inhibition of A-to-I RNA Editing with 2′-O-Methyl/Locked Nucleic Acid-Containing Antisense Oligoribonucleotides [PDF]

ACS Chemical Biology, 2013
Rena A. Mizrahi, N.T. Schirle, Peter A. Beal   +2 more
openalex   +2 more sources

A-to-I RNA Editing and Hematopoiesis.

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen Liang, Carl R. Walkley, Jacki E. Heraud-Farlow   +2 more
semanticscholar   +3 more sources

Adaptation of A-to-I RNA editing in bacteria, fungi, and animals. [PDF]

Front Microbiol, 2023
Duan Y, Li H, Cai W.
europepmc   +4 more sources