The majority of A-to-I RNA editing is not required for mammalian homeostasis
Genome Biology, 2019 Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes. A-to-I editing can change the protein coding potential of a transcript and alter RNA splicing, miRNA
A. Chalk +3 more
semanticscholar +2 more sources
Expanding the proteome: A-to-I RNA editing provides an adaptive advantage. [PDF]
Proc Natl Acad Sci U S A, 2023 RNA editing refers to the post-transcriptional modification of RNA sequences. Diverse eukaryotes are capable of mRNA editing, most commonly through enzymatic deamination of adenosine-to-inosine (A-to-I) (1–3).
Lewis ZA.
europepmc +2 more sources
Reciprocal regulation of A-to-I RNA editing and the vertebrate nervous system [PDF]
Frontiers in Neuroscience, 2013 The fine control of molecules mediating communication in the nervous system is key to adjusting neuronal responsiveness during development and in maintaining the stability of established networks in the face of altered sensory input.
Andrew Charles Penn +3 more
doaj +3 more sources
A-to-I RNA editing: current knowledge sources and computational approaches with special emphasis on non-coding RNA molecules [PDF]
Frontiers in Bioengineering and Biotechnology, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Giovanni eNigita +2 more
doaj +3 more sources
The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers. [PDF]
Genomics Proteomics Bioinformatics, 2023 Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers.
Wu S, Fan Z, Kim P, Huang L, Zhou X.
europepmc +2 more sources
A-to-I RNA Editing in the Earliest-Diverging Eumetazoan Phyla [PDF]
Molecular biology and evolution, 2017 The highly conserved ADAR enzymes, found in all multicellular metazoans, catalyze the editing of mRNA transcripts by the deamination of adenosines to inosines.
Hagit T. Porath +7 more
semanticscholar +3 more sources
De Novo A-to-I RNA Editing Discovery in lncRNA [PDF]
Cancers, 2020 Simple Summary Long non-coding RNAs are emerging as key regulators of gene expression at both transcriptional and translational levels, and their alterations (in expression or sequence) are linked to tumorigenesis and tumor progression.
Domenico A Silvestris +4 more
semanticscholar +4 more sources
Profiling A-to-I RNA editing during mouse somatic reprogramming at the single-cell level. [PDF]
Heliyon, 2023 Mouse somatic cells can be reprogrammed into induced pluripotent stem cells through a highly heterogeneous process regulated by numerous biological factors, including adenosine-to-inosine (A-to-I) RNA editing.
Lv T, Jiang S, Wang X, Hou Y.
europepmc +2 more sources
Host A-to-I RNA editing signatures in intracellular bacterial and single-strand RNA viral infections. [PDF]
Front Immunol, 2023 BackgroundMicrobial infection is accompanied by remodeling of the host transcriptome. Involvement of A-to-I RNA editing has been reported during viral infection but remains to be elucidated during intracellular bacterial infections.ResultsHerein we ...
Wei ZY +10 more
europepmc +2 more sources
Uncovering Cis-Regulatory Elements Important for A-to-I RNA Editing in Fusarium graminearum. [PDF]
mBio, 2022 Adenosine-to-inosine (A-to-I) RNA editing independent of adenosine deaminase acting on RNA (ADAR) enzymes was discovered in fungi recently, and shown to be crucial for sexual reproduction. However, the underlying mechanism for editing is unknown.
Feng C +8 more
europepmc +2 more sources