Results 11 to 20 of about 413,067 (133)
Advances in A-to-I RNA editing in cancer. [PDF]
Mol CancerRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers.
Zhang Y +9 more
europepmc +2 more sources
Adaptation of A-to-I RNA editing in bacteria, fungi, and animals. [PDF]
Front Microbiol, 2023 Duan Y, Li H, Cai W.
europepmc +2 more sources
Ocular A-to-I RNA editing signatures associated with SARS-CoV-2 infection. [PDF]
BMC GenomicsOphthalmic manifestations have recently been observed in acute and post-acute complications of COVID-19 caused by SARS-CoV-2 infection. Our precious study has shown that host RNA editing is linked to RNA viral infection, yet ocular adenosine to inosine ...
Jin YY +8 more
europepmc +2 more sources
The Many Roles of A-to-I RNA Editing in Animals: Functional or Adaptive?
Frontiers in Bioscience-Landmark, 2023 Metazoan adenosine-to-inosine (A-to-I) RNA editing is a highly conserved mechanism that diversifies the transcriptome by post-transcriptionally converting adenosine to inosine.
Dongwu Zhan +4 more
doaj +1 more source
REDIportal: millions of novel A-to-I RNA editing events from thousands of RNAseq experiments
Nucleic Acids Res., 2020 RNA editing is a relevant epitranscriptome phenomenon able to increase the transcriptome and proteome diversity of eukaryotic organisms. ADAR mediated RNA editing is widespread in humans in which millions of A-to-I changes modify thousands of primary ...
L. Mansi +9 more
semanticscholar +1 more source
L-GIREMI uncovers RNA editing sites in long-read RNA-seq
Genome Biology, 2023 Although long-read RNA-seq is increasingly applied to characterize full-length transcripts it can also enable detection of nucleotide variants, such as genetic mutations or RNA editing sites, which is significantly under-explored.
Zhiheng Liu +7 more
doaj +1 more source
The cell line A-to-I RNA editing catalogue
Nucleic Acids Research, 2020 Adenosine-to-inosine (A-to-I) RNA editing is a common post transcriptional modification. It has a critical role in protecting against false activation of innate immunity by endogenous double stranded RNAs and has been associated with various regulatory ...
Amos A Schaffer +5 more
semanticscholar +1 more source
Zinc Finger RNA-Binding Protein Zn72D Regulates ADAR-Mediated RNA Editing in Neurons
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing, catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes, alters RNA sequences from those encoded by DNA. These editing events are dynamically regulated, but few trans regulators of ADARs are known in vivo.
Anne L. Sapiro +8 more
doaj +1 more source
Genetic variation and microRNA targeting of A-to-I RNA editing fine tune human tissue transcriptomes
Genome Biology, 2021 Background A-to-I RNA editing diversifies the transcriptome and has multiple downstream functional effects. Genetic variation contributes to RNA editing variability between individuals and has the potential to impact phenotypic variability.
Eddie Park +4 more
doaj +1 more source
A hierarchy in clusters of cephalopod mRNA editing sites
Scientific Reports, 2022 RNA editing in the form of substituting adenine with inosine (A-to-I editing) is the most frequent type of RNA editing in many metazoan species. In most species, A-to-I editing sites tend to form clusters and editing at clustered sites depends on editing
Mikhail A. Moldovan +3 more
doaj +1 more source