The evolution and adaptation of A-to-I RNA editing
PLOS Genetics, 2017 Adenosine-to-inosine (A-to-I) RNA editing is an important post-transcriptional modification that affects the information encoded from DNA to RNA to protein.
Arielle Yablonovitch +3 more
semanticscholar +5 more sources
Conserved A-to-I RNA editing with non-conserved recoding expands the candidates of functional editing sites. [PDF]
Fly (Austin)Adenosine-to-inosine (A-to-I) RNA editing recodes the genome and confers flexibility for the organisms to adapt to the environment. It is believed that RNA recoding sites are well suited for facilitating adaptive evolution by increasing the proteomic ...
Duan Y +8 more
europepmc +2 more sources
Discriminative Prediction of A-To-I RNA Editing Events from DNA Sequence [PDF]
PLoS ONE, 2016 RNA editing is a post-transcriptional alteration of RNA sequences that, via insertions, deletions or base substitutions, can affect protein structure as well as RNA and protein expression.
Jiangming Sun +8 more
semanticscholar +2 more sources
Population and allelic variation of A-to-I RNA editing in human transcriptomes [PDF]
Genome Biology, 2017 Background A-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Eddie Park +6 more
doaj +4 more sources
An orthology-based methodology as a complementary approach to retrieve evolutionarily conserved A-to-I RNA editing sites. [PDF]
RNA BiolAdar-mediated adenosine-to-inosine (A-to-I) mRNA editing is a conserved mechanism that exerts diverse regulatory functions during the development, evolution, and adaptation of metazoans.
Liu J +8 more
europepmc +2 more sources
Quantitative Analysis of Focused A-To-I RNA Editing Sites by Ultra-High-Throughput Sequencing in Psychiatric Disorders [PDF]
PLoS ONE, 2012 A-to-I RNA editing is a post-transcriptional modification of single nucleotides in RNA by adenosine deamination, which thereby diversifies the gene products encoded in the genome.
Hu Zhu +14 more
semanticscholar +2 more sources
The Role of RNA Editing in Cancer Development and Metabolic Disorders [PDF]
Frontiers in Endocrinology, 2018 Numerous human diseases arise from alterations of genetic information, most notably DNA mutations. Thought to be merely the intermediate between DNA and protein, changes in RNA sequence were an afterthought until the discovery of RNA editing 30 years ago.
Che-Pei Kung +6 more
doaj +3 more sources
Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]
Frontiers in Genetics, 2013 RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, tRNA, rRNA, and non-coding RNAs.
Minati eSingh
doaj +3 more sources
Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]
Frontiers in Oncology, 2020 A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and ...
Chi Zhou +4 more
doaj +3 more sources
A-to-I RNA Editing and Human Disease [PDF]
RNA Biology, 2006 The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has been recognized as an important mechanism for the generation of molecular diversity and also regulates protein function through recoding of genomic information.
S. Maas +3 more
semanticscholar +3 more sources