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A-To-I RNA Editing By ADAR1 Is Essential For Hematopoiesis

Blood, 2013
Abstract The role of RNA and its regulation is becoming increasingly appreciated as a vital component of hematopoietic development. RNA editing by members of the Adenosine Deaminase Acting on RNA (ADAR) gene family is a form of post-transcriptional modification which converts genomically encoded adenosine to inosine (A-to-I) in double ...
Brian Liddicoat   +7 more
openaire   +2 more sources

ALU A-to-I RNA Editing: Millions of Sites and Many Open Questions.

Methods in molecular biology, 2021
Amos A Schaffer, E. Levanon
semanticscholar   +1 more source

Computational approaches for detection and quantification of A-to-I RNA-editing

Methods, 2019
Adenosine deaminases that act on RNA (ADARs) catalyze adenosine-to-inosine (A-to-I) RNA editing in double-stranded RNA. Such editing is important for protection against false activation of the immune system, but also confers plasticity on the transcriptome by generating several versions of a transcript from a single genomic locus.
Yishay Pinto, Erez Y. Levanon
openaire   +3 more sources

Genome-wide analysis of A-to-I RNA editing by single-molecule sequencing in Drosophila

Nature Structural &Molecular Biology, 2013
G. Laurent   +9 more
semanticscholar   +1 more source

Cryo-EM SPA for structural understanding of A-to-I RNA editing: human adenosine deaminase acting on RNA 2 (ADAR2) complexed with dsRNA

Acta Crystallographica Section A: Foundations and Advances, 2023
Mellissa Matthrew   +4 more
semanticscholar   +1 more source

Base editing: advances and therapeutic opportunities

Nature Reviews Drug Discovery, 2020
Alexis C Komor, Gene W Yeo, Rui Kang
exaly  

Spatiotemporal Delivery of CRISPR/Cas9 Genome Editing Machinery Using Stimuli‐Responsive Vehicles

Angewandte Chemie - International Edition, 2021
Lanqun Mao, Ming Wang
exaly  

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