Results 31 to 40 of about 515,927 (320)

Population and allelic variation of A-to-I RNA editing in human transcriptomes. [PDF]

, 2017
BackgroundA-to-I RNA editing is an important step in RNA processing in which specific adenosines in some RNA molecules are post-transcriptionally modified to inosines.
Demirdjian, Levon, Guo, Jiguang, Lin, Lan, Park, Eddie, Shen, Shihao, Wu, Ying Nian, Xing, Yi   +6 more
core   +2 more sources

A-to-I RNA Editing in Cancer: From Evaluating the Editing Level to Exploring the Editing Effects [PDF]

Frontiers in Oncology, 2021
As an important regulatory mechanism at the posttranscriptional level in metazoans, adenosine deaminase acting on RNA (ADAR)-induced A-to-I RNA editing modification of double-stranded RNA has been widely detected and reported. Editing may lead to non-synonymous amino acid mutations, RNA secondary structure alterations, pre-mRNA processing changes, and ...
Heming Wang, Heming Wang, Heming Wang, Sinuo Chen, Sinuo Chen, Jiayi Wei, Jiayi Wei, Guangqi Song, Guangqi Song, Yicheng Zhao   +9 more
openaire   +4 more sources

Reduced levels of protein recoding by A-to-I RNA editing in Alzheimer's disease

RNA: A publication of the RNA Society, 2016
Adenosine to inosine (A-to-I) RNA editing, catalyzed by the ADAR enzyme family, acts on dsRNA structures within pre-mRNA molecules. Editing of the coding part of the mRNA may lead to recoding, amino acid substitution in the resulting protein, possibly ...
K. Khermesh, A. D’Erchia, Michal Barak, A. Annese, Chaim Wachtel, E. Levanon, E. Picardi, E. Eisenberg   +7 more
semanticscholar   +1 more source

Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]

, 2012
RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik, Altschul, Andrew C. Penn, Aruscavage, Bass, Birney, Bratt, Brorson, Coleman, Coleman, Daniel, Darty, Dawson, de la Mata, Feldmeyer, Feng, Fisahn, Gahwiler, Gainey, Gallo, Ge, Goodman, Greger, Greger, Greger, Gurevich, Hamada, Hideyama, Hideyama, Higuchi, Higuchi, Hoopengardner, Hundley, Ingo H. Greger, Jepson, Katoh, Kent, Lee, Lein, Li, Liu, Lomeli, Maas, Marcucci, Palladino, Paul, Peng, Peng, Penn, Penn, Penn, Pozo, Rosenthal, Rueter, Ryman, Sanjana, Schoft, Seeburg, Seeburg, Sommer, Sommer, Stefl, Stefl, Tariq, Toth, Traynelis, Turrigiano, Turrigiano, Valente, Venkatesh, Wang, Witter, Xie, Zsofia Nemoda   +73 more
core   +1 more source

RNA editing contributes to epitranscriptome diversity in chronic lymphocytic leukemia [PDF]

, 2021
RNA editing—primarily conversion of adenosine to inosine (A > I)—is a widespread posttranscriptional mechanism, mediated by Adenosine Deaminases acting on RNA (ADAR) enzymes to alter the RNA sequence of primary transcripts.
Buchumenski, Ilana, Campo, Elias, Egle, Alexander, Gassner, Franz, Gatterbauer, Matthias, Geisberger, Roland, Greil, Richard, Hebenstreit, Daniel, Levanon, Erez, Nadeu, Ferran, Rauscher, Stefanie, Schubert, Maria, Zaborsky, Nadja   +12 more
core   +1 more source

A biochemical landscape of A-to-I RNA editing in the human brain transcriptome

Genome Research, 2014
Inosine is an abundant RNA modification in the human transcriptome and is essential for many biological processes in modulating gene expression at the post-transcriptional level.
M. Sakurai, H. Ueda, T. Yano, Shunpei Okada, Hideki Terajima, Toutai Mitsuyama, A. Toyoda, A. Fujiyama, H. Kawabata, Tsutomu Suzuki   +9 more
semanticscholar   +1 more source

[Inefficient A-to-I RNA editing and ALS].

Rinsho Shinkeigaku, 2010
GluR2 is a subunit of the AMPA receptor, and failure of naturally occurring adenosine to inosine (A-to-I) conversion at its Q R site results in an increase of Ca influx through the AMPA receptor, thereby inducing exaggerated neuronal excitation. Indeed, mutant mice unable to edit this site die from status epilepticus.
S. Kwak
semanticscholar   +5 more sources

Comparative RNA editing in autistic and neurotypical cerebella [PDF]

, 2012
Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals.
Brown, Emery N., Calvo, Sarah E., Collins, C., Eran, A., Kohane, Isaac, Kunkel, Louis M., Li, J. B., Margulies, David M., Markianos, K., McCarthy, J., Rahimov, F., Vatalaro, K.   +11 more
core   +1 more source

Genetic Control of RNA Editing in Neurodegenerative Disease [PDF]

, 2023
A-to-I RNA editing diversifies human transcriptome to confer its functional effects on the downstream genes or regulations, potentially involving in neurodegenerative pathogenesis.
Huang, Liyu, Kim, Pora, Wang, Yanfei, Wu, Sijia, Xue, Qiuping, Yang, Mengyuan, Zhou, Xiaobo   +6 more
core   +2 more sources

N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]

Molecular Cell, 2018
N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Qin Yang, Chu-Xiao Liu, Ling-Ling Chen, Ling-Ling Chen, Man Wu, Li Yang, Li Yang, Jian-Feng Xiang   +7 more
openaire   +3 more sources