Results 31 to 40 of about 574,299 (199)

Substitutional A‐to‐I RNA editing [PDF]

WIREs RNA, 2010
AbstractAdenosine‐to‐inosine (A‐to‐I) editing catalyzed by adenosine deaminases acting on RNA (ADARs) entails the chemical conversion of adenosine residues to inosine residues within double‐stranded RNA (dsRNA) substrates. Inosine base pairs as guanosine and A‐to‐I editing can therefore alter the structure and base pairing properties of the RNA ...
B. Wulff, K. Nishikura
semanticscholar   +3 more sources

A-to-I RNA Editing and Hematopoiesis.

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen Liang, Carl R. Walkley, Jacki E. Heraud-Farlow   +2 more
semanticscholar   +3 more sources

Increased A-to-I RNA editing in atherosclerosis and cardiomyopathies. [PDF]

PLoS Comput Biol, 2023
Adenosine-to-inosine RNA editing is essential to prevent undesired immune activation. This diverse process alters the genetic content of the RNA and may recode proteins, change splice sites and miRNA targets, and mimic genomic mutations. Recent studies have associated or implicated aberrant editing with pathological conditions, including cancer ...
Mann TD, Kopel E, Eisenberg E, Levanon EY.   +3 more
europepmc   +5 more sources

[Inefficient A-to-I RNA editing and ALS].

Rinsho Shinkeigaku, 2010
S. Kwak
semanticscholar   +4 more sources

Elevated A-to-I RNA editing in COVID-19 infected individuals. [PDF]

NAR Genom Bioinform, 2023
Abstract Given the current status of coronavirus disease 2019 (COVID-19) as a global pandemic, it is of high priority to gain a deeper understanding of the disease's development and how the virus impacts its host. Adenosine (A)-to-Inosine (I) RNA editing is a post-transcriptional modification, catalyzed by the ADAR family of enzymes ...
Merdler-Rabinowicz R, Gorelik D, Park J, Meydan C, Foox J, Karmon M, Roth HS, Cohen-Fultheim R, Shohat-Ophir G, Eisenberg E, Ruppin E, Mason CE, Levanon EY.   +12 more
europepmc   +3 more sources

Advances in Detection Methods for A-to-I RNA Editing. [PDF]

Wiley Interdiscip Rev RNA
ABSTRACTAdenosine‐to‐inosine (A‐to‐I) RNA editing is a key post‐transcriptional modification that influences gene expression and various cellular processes. Advances in sequencing technologies have greatly contributed to the identification of A‐to‐I editing sites, providing insights into their distribution across coding and non‐coding regions.
Yang Y, Sakurai M.
europepmc   +3 more sources

Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage. [PDF]

RNA: A publication of the RNA Society, 2013
Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Pierre B. Cattenoz, R. Taft, E. Westhof, J. Mattick   +3 more
semanticscholar   +4 more sources

N6-Methyladenosines Modulate A-to-I RNA Editing [PDF]

Molecular Cell, 2018
N6-methyladenosine (m6A) and adenosine-to-inosine (A-to-I) editing are two of the most abundant RNA modifications, both at adenosines. Yet, the interaction of these two types of adenosine modifications is largely unknown. Here we show a global A-to-I difference between m6A-positive and m6A-negative RNA populations.
Jian-Feng, Xiang, Qin, Yang, Chu-Xiao, Liu, Man, Wu, Ling-Ling, Chen, Li, Yang   +5 more
openaire   +2 more sources

Activity-Dependent A-to-I RNA Editing in Rat Cortical Neurons [PDF]

Genetics, 2012
Abstract Changes in neural activity influence synaptic plasticity/scaling, gene expression, and epigenetic modifications. We present the first evidence that short-term and persistent changes in neural activity can alter adenosine-to-inosine (A-to-I) RNA editing, a post-transcriptional site-specific modification found in several neuron ...
Neville E. Sanjana, E. Levanon, Emily A Hueske, J. Ambrose, J. B. Li   +4 more
semanticscholar   +3 more sources

Steric antisense inhibition of AMPA receptor Q/R editing reveals tight coupling to intronic editing sites and splicing [PDF]

, 2012
Adenosine-to-Inosine (A-to-I) RNA editing is a post-transcriptional mechanism, evolved to diversify the transcriptome in metazoa. In addition to wide-spread editing in non-coding regions protein recoding by RNA editing allows for fine tuning of protein ...
Ales Balik, Altschul, Andrew C. Penn, Arzumanov, Arzumanov, Balik, Bass, Birney, Brusa, Carver, Daniel, Darty, Dominski, Egebjerg, Eisen, Enstero, Feldmeyer, Gallo, Ge, Greger, Hamada, Heasman, Higuchi, Higuchi, Hogg, Ingo H. Greger, Jepson, Jubin, Katoh, Kent, Kwak, Laurencikiene, Maas, Moulton, Peng, Reenan, Rice, Rosenthal, Rueter, Ryman, Schoft, Sommer, Stephens, Summerton, Summerton, Summerton, Tariq, Traynelis, Valente, Venkatesh, Yamashita, Yang   +51 more
core   +1 more source