A-to-I RNA Editing: Current Knowledge Sources and Computational Approaches with Special Emphasis on Non-Coding RNA Molecules [PDF]
, 2015 RNA editing is a dynamic mechanism for gene regulation attained through the alteration of the sequence of primary RNA transcripts. A-to-I (Adenosine-to-Inosine) RNA editing, which is catalyzed by members of the Adenosine Deaminase Acting on RNA (ADAR ...
Alfredo Ferro +2 more
core +2 more sources
A Role for A-to-I RNA Editing in Temperature Adaptation [PDF]
Physiology, 2012 A-to-I RNA editing can recode mRNAs, giving organisms the option to express diverse, functionally distinct protein isoforms. Here, we propose that RNA editing is inherently geared for temperature adaptation because it tends to recode to smaller, less stabilizing amino acids. Studies on how editing affects protein function support this idea.
Joshua J. C. Rosenthal +1 more
openaire +3 more sources
Actions of Agonists, Fipronil and Ivermectin on the Predominant In Vivo Splice and Edit Variant (RDLbd, I/V) of the Drosophila GABA Receptor Expressed in Xenopus laevis Oocytes [PDF]
, 2014 Ionotropic GABA receptors are the targets for several classes of insecticides. One of the most widely-studied insect GABA receptors is RDL (resistance to dieldrin), originally isolated from Drosophila melanogaster.
Biggin, P +5 more
core +7 more sources
Transcriptome-wide identification of A > I RNA editing sites by inosine specific cleavage [PDF]
, 2013 Adenosine to inosine (A > I) RNA editing, which is catalyzed by the ADAR family of proteins, is one of the fundamental mechanisms by which transcriptomic diversity is generated.
Cattenoz, Pierre B. +3 more
core +2 more sources
Systematically Characterizing A-to-I RNA Editing Neoantigens in Cancer [PDF]
Frontiers in Oncology, 2020 A-to-I RNA editing can contribute to the transcriptomic and proteomic diversity of many diseases including cancer. It has been reported that peptides generated from RNA editing could be naturally presented by human leukocyte antigen (HLA) molecules and elicit CD8+ T cell activation.
Liye Zhang +4 more
openaire +4 more sources
Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA [PDF]
, 2012 Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may ...
Barraud +59 more
core +3 more sources
A-to-I RNA Editing: Recent News and Residual Mysteries*
Journal of Biological Chemistry, 2003 Adenosine to inosine modification in pre-mRNA, with inosine acting as guanosine during translation, was the most recent type of RNA editing to be discovered (1).
S. Maas, A. Rich, K. Nishikura
semanticscholar +1 more source
Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates
Genome Biology, 2019 BackgroundRecent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general functions of these events are not well addressed.ResultsHere, we perform a comparative editome study in human and rhesus macaque ...
Ni A. An +11 more
semanticscholar +2 more sources
RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity [PDF]
, 2008 A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122 ...
A. Hamon +3 more
core +2 more sources
Altered A-to-I RNA Editing in Human Embryogenesis
PLoS ONE, 2012 Post-transcriptional events play an important role in human development. The question arises as to whether Adenosine to Inosine RNA editing, catalyzed by the ADAR (Adenosine Deaminase acting on RNA) enzymes, differs in human embryogenesis and in adulthood.
Ronit Shtrichman +9 more
openaire +5 more sources