Brain Epitranscriptomic Analysis Revealed Altered A-to-I RNA Editing in Septic Patients
Frontiers in Genetics, 2022 Recent studies suggest that RNA editing is associated with impaired brain function and neurological and psychiatric disorders. However, the role of A-to-I RNA editing during sepsis-associated encephalopathy (SAE) remains unclear.
Jing-Qian Zhang +22 more
doaj +1 more source
Massive A-to-I RNA editing is common across the Metazoa and correlates with dsRNA abundance
Genome Biology, 2017 Adenosine to inosine (A-to-I) RNA editing is a post-transcriptional modification catalyzed by the ADAR (adenosine deaminase that acts on RNA) enzymes, which are ubiquitously expressed among metazoans.
Hagit T. Porath +3 more
semanticscholar +1 more source
DNA editing in DNA/RNA hybrids by adenosine deaminases that act on RNA. [PDF]
, 2017 Adenosine deaminases that act on RNA (ADARs) carry out adenosine (A) to inosine (I) editing reactions with a known requirement for duplex RNA. Here, we show that ADARs also react with DNA/RNA hybrid duplexes.
Beal, Peter A +2 more
core +1 more source
Activity-regulated RNA editing in select neuronal subfields in hippocampus [PDF]
, 2012 RNA editing by adensosine deaminases is a widespread mechanism to alter genetic information in metazoa. In addition to modifications in non-coding regions, editing contributes to diversification of protein function, in analogy to alternative splicing ...
Ales Balik +73 more
core +1 more source
Evolutionarily significant A-to-I RNA editing events originated through G-to-A mutations in primates
Genome Biology, 2019 BackgroundRecent studies have revealed thousands of A-to-I RNA editing events in primates, but the origination and general functions of these events are not well addressed.ResultsHere, we perform a comparative editome study in human and rhesus macaque ...
Ni A. An +11 more
semanticscholar +2 more sources
Chemical Profiling of A-to-I RNA Editing Using a Click-Compatible Phenylacrylamide.
Chemistry, 2020 Straightforward methods for detecting adenosine-to-inosine (A-to-I) RNA editing are key to better understanding its regulation, function, and connection with disease.
Steve D. Knutson +7 more
semanticscholar +1 more source
Comparative RNA editing in autistic and neurotypical cerebella [PDF]
, 2012 Adenosine-to-inosine (A-to-I) RNA editing is a neurodevelopmentally regulated epigenetic modification shown to modulate complex behavior in animals.
Brown, Emery N. +11 more
core +1 more source
Illuminating spatial A-to-I RNA editing signatures within the Drosophila brain
Proceedings of the National Academy of Sciences of the United States of America, 2018 Significance A fundamental question in contemporary neuroscience is how the remarkable cellular diversity required for the intricate function of the nervous system is achieved.
Anne L. Sapiro +8 more
semanticscholar +1 more source
A-to-I RNA editing – thinking beyond the single nucleotide [PDF]
RNA Biology, 2017 Adenosine-to-inosine RNA editing is a conserved process, which is performed by ADAR enzymes. By changing nucleotides in coding regions of genes and altering codons, ADARs expand the cell's protein repertoire. This function of the ADAR enzymes is essential for human brain development. However, most of the known editing sites are in non-coding repetitive
Nabeel S. Ganem, Ayelet T. Lamm
openaire +2 more sources
Unbiased Identification of trans Regulators of ADAR and A-to-I RNA Editing
Cell Reports, 2020 Summary: Adenosine-to-inosine RNA editing is catalyzed by adenosine deaminase acting on RNA (ADAR) enzymes that deaminate adenosine to inosine. Although many RNA editing sites are known, few trans regulators have been identified.
Emily C. Freund +6 more
doaj +1 more source