RNA editing signature during myeloid leukemia cell differentiation [PDF]
, 2017 Adenosine deaminases acting on RNA (ADARs) are key proteins for hematopoietic stem cell self-renewal and for survival of differentiating progenitor cells. However, their specific role in myeloid cell maturation has been poorly investigated.
A Athanasiadis +48 more
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Differential Enzymatic Activity of Rat ADAR2 Splicing Variants Is Due to Altered Capability to Interact with RNA in the Deaminase Domain [PDF]
, 2018 In mammals, adenosine (A) to inosine (I) RNA editing is performed by adenosine deaminases acting on RNA (ADAR), ADAR1 and ADAR2 enzymes, encoded by mRNAs that might undergo splicing process.
Barbon, Alessandro +6 more
core +2 more sources
Dysregulated A to I RNA editing and non-coding RNAs in neurodegeneration [PDF]
Frontiers in Genetics, 2013 RNA editing is an alteration in the primary nucleotide sequences resulting from a chemical change in the base. RNA editing is observed in eukaryotic mRNA, transfer RNA, ribosomal RNA, and non-coding RNAs (ncRNA). The most common RNA editing in the mammalian central nervous system is a base modification, where the adenosine residue is base-modified to ...
openaire +4 more sources
RDDpred: a condition-specific RNA-editing prediction model from RNA-seq data [PDF]
, 2016 This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give ...
Benjamin Hur, Min-su Kim, Sun Kim
core +2 more sources
The contribution of Alu exons to the human proteome. [PDF]
, 2016 BackgroundAlu elements are major contributors to lineage-specific new exons in primate and human genomes. Recent studies indicate that some Alu exons have high transcript inclusion levels or tissue-specific splicing profiles, and may play important ...
Jiang, Peng +7 more
core +1 more source
Systematic identification of edited microRNAs in the human brain [PDF]
, 2012 Adenosine-to-inosine (A-to-I) editing modifies RNA transcripts from their genomic blueprint. A prerequisite for this process is a double-stranded RNA (dsRNA) structure.
Alon, Shahar +8 more
core +1 more source
The majority of A-to-I RNA editing is not required for mammalian homeostasis [PDF]
Genome Biology, 2019 Abstract Background Adenosine-to-inosine (A-to-I) RNA editing, mediated by ADAR1 and ADAR2, occurs at tens of thousands to millions of sites across mammalian transcriptomes. A-to-I editing can change the protein coding potential of a transcript and alter RNA splicing, miRNA biology, RNA secondary structure and formation ...
Carl R. Walkley +7 more
openaire +6 more sources
Zalpha-domains: At the intersection between RNA editing and innate immunity [PDF]
, 2012 The involvement of A to I RNA editing in antiviral responses was first indicated by the observation of genomic hyper-mutation for several RNA viruses in the course of persistent infections.
Athanasiadis, Alekos
core +1 more source
bioRxiv, 2018 RNA editing diversifies genomically encoded information to expand the complexity of the transcriptome. In ectothermic organisms, including Drosophila and Cephalopoda, where body temperature mirrors ambient temperature, decreases in environmental ...
K. Riemondy +5 more
semanticscholar +1 more source
CRISPR/Cas9‐mediated genome editing: from basic research to translational medicine [PDF]
, 2020 The recent development of the CRISPR/Cas9 system as an efficient and accessible programmable genome-editing tool has revolutionized basic science research. CRISPR/Cas9 system-based technologies have armed researchers with new powerful tools to unveil the
Ferreira, B I +2 more
core +1 more source