Results 51 to 60 of about 584,058 (291)

RESIC: A Tool for Comprehensive Adenosine to Inosine RNA Editing Site Identification and Classification

Frontiers in Genetics, 2021
Adenosine to inosine (A-to-I) RNA editing, the most prevalent type of RNA editing in metazoans, is carried out by adenosine deaminases (ADARs) in double-stranded RNA regions.
Dean Light, Roni Haas, Mahmoud Yazbak, Tal Elfand, Tal Blau, Ayelet T. Lamm   +5 more
doaj   +1 more source

Knowledge in the Investigation of A-to-I RNA Editing Signals [PDF]

Frontiers in Bioengineering and Biotechnology, 2015
RNA editing is a post-transcriptional alteration of RNA sequences that is able to affect protein structure as well as RNA and protein expression. Adenosine-to-inosine (A-to-I) RNA editing is the most frequent and common post-transcriptional modification in human, where adenosine (A) deamination produces its conversion into inosine (I), which in turn is
Nigita G, Alaimo S, FERRO, Alfredo, Giugno R, PULVIRENTI, ALFREDO   +4 more
openaire   +3 more sources

RNA editing regulates insect gamma-aminobutyric acid receptor function and insecticide sensitivity [PDF]

, 2008
A-to-I pre-mRNA editing by adenosine deaminase enzymes has been reported to enhance protein diversity in the nervous system. In Drosophila, the resistance to dieldrin (RDL) gamma-aminobutyric acid (GABA) receptor subunit displays an editing site (R122 ...
A. Hamon, B. Lapied, G. Le Goff, Z. Es-Salah-Lamoureux   +3 more
core   +3 more sources

Solution structure of the N-terminal dsRBD of Drosophila ADAR and interaction studies with RNA [PDF]

, 2012
Adenosine deaminases that act on RNA (ADAR) catalyze adenosine to inosine (A-to-I) editing in double-stranded RNA (dsRNA) substrates. Inosine is read as guanosine by the translation machinery; therefore A-to-I editing events in coding sequences may ...
Barraud, Barraud, Barraud, Bass, Bhalla, Blaszczyk, Bratt, Bret S.E. Heale, Brunger, Brunger, Burns, Bycroft, Chang, Cho, DeLano, Dominguez, Duss, Eggington, Fierro-Monti, Frédéric H.-T. Allain, Gallo, Gan, Goddard, Graveley, Guntert, Guntert, Herrmann, Herrmann, Higuchi, Hood, Hoopengardner, Keegan, Keegan, Kharrat, Krovat, Laskowski, Lehmann, Leulliot, Lomeli, Maas, Macbeth, Mary A. O’Connell, Nishikura, Palladino, Palladino, Paro, Pierre Barraud, Ramos, Ryter, Saunders, Sommer, Stapleton, Stefl, Stefl, Stefl, Stephens, Valente, Wang, Wu, Yang   +59 more
core   +4 more sources

Recommendations for detection, validation, and evaluation of RNA editing events in cardiovascular and neurological/neurodegenerative diseases

Molecular Therapy: Nucleic Acids
RNA editing, a common and potentially highly functional form of RNA modification, encompasses two different RNA modifications, namely adenosine to inosine (A-to-I) and cytidine to uridine (C-to-U) editing. As inosines are interpreted as guanosines by the
Korina Karagianni, Alessia Bibi, Alisia Madé, Shubhra Acharya, Mikko Parkkonen, Teodora Barbalata, Prashant K. Srivastava, David de Gonzalo-Calvo, Constanza Emanueli, Fabio Martelli, Yvan Devaux, Dimitra Dafou, A. Yaël Nossent   +12 more
doaj   +1 more source

A comprehensive study on cellular RNA editing activity in response to infections with different subtypes of influenza a viruses

BMC Genomics, 2018
Background RNA editing is an important mechanism that expands the diversity and complexity of genetic codes. The conversions of adenosine (A) to inosine (I) and cytosine (C) to uridine (U) are two prominent types of RNA editing in animals.
Yingying Cao, Ruiyuan Cao, Yaowei Huang, Hongxia Zhou, Yuanhua Liu, Xuan Li, Wu Zhong, Pei Hao   +7 more
doaj   +1 more source

Developmental stage-specific A-to-I editing pattern in the postnatal pineal gland of pigs (Sus scrofa)

Journal of Animal Science and Biotechnology, 2020
Background RNA editing is a widespread post-transcriptional modification mechanism in mammalian genomes. Although many editing sites have been identified in domestic pigs (Sus scrofa), little is known about the characteristics and dynamic regulation of ...
Rong Zhou, Wenye Yao, Chundi Xie, Leixia Zhang, Yangli Pei, Hua Li, Zheng Feng, Yalan Yang, Kui Li   +8 more
doaj   +1 more source

A-to-I RNA editing and hematopoiesis

Experimental Hematology
Adenosine-to-inosine (A-to-I) RNA editing plays essential roles in modulating normal development and homeostasis. This process is catalyzed by adenosine deaminase acting on RNA (ADAR) family proteins. The most well-understood biological processes modulated by A-to-I editing are innate immunity and neurological development, attributed to ADAR1 and ADAR2,
Zhen, Liang, Carl R, Walkley, Jacki E, Heraud-Farlow   +2 more
openaire   +2 more sources

Large-scale analysis of structural, sequence and thermodynamic characteristics of A-to-I RNA editing sites in human Alu repeats [PDF]

, 2010
Background Alu repeats in the human transcriptome undergo massive adenosine to inosine RNA editing. This process is selective, as editing efficiency varies greatly among different adenosines.
Yoav Kleinberger, Eli Eisenberg
core   +2 more sources

Reovirus infection induces transcriptome-wide unique A-to-I editing changes in the murine fibroblasts.

Virus Research
The conversion of Adenosine (A) to Inosine (I), by Adenosine Deaminases Acting on RNA or ADARs, is an essential post-transcriptional modification that contributes to proteome diversity and regulation in metazoans including humans.
Ayesha Tariq, Helen Piontkivska
doaj   +1 more source