Results 181 to 190 of about 1,621,127 (284)

Continuous Imaging of the Cardiac Cycle Metabolism With Hyperpolarized [1‐13C]Pyruvate

NMR in Biomedicine, Volume 39, Issue 11, November 2026.
We present a continuous hyperpolarized 13C MRI framework for phase‐resolved imaging of myocardial metabolism throughout the entire cardiac cycle. By combining spectral‐spatial bicarbonate excitation with frequency‐shifted reconstruction of residual pyruvate signal, both metabolites are obtained from a single acquisition.
Mohsen Redda, Nikolaj Bøgh, Esben Søvsø Szocska Hansen, Uffe Kjærgaard, Rolf F. Schulte, Christoffer Laustsen   +5 more
wiley   +1 more source

Tuning the Triazolotriazine Scaffold Toward Selective A3 Adenosine Receptor Antagonists: From Molecular Recognition to Neuroprotection

ChemMedChem, Volume 21, Issue 20, 28 October 2026.
Structure‐based optimization of the triazolo‐triazine scaffold afforded highly potent and selective adenosine A3 receptor antagonists. Replacement of the classical 2‐furyl group with phenyl‐based substituents markedly improved A3 receptor affinity and selectivity.
Veronika Kost, Filippo Prencipe, Federica Panozzi, Veronica Salmaso, Sonja Kachler, Karl‐Norbert Klotz, Elisabetta Coppi, Simone Adorinni, Stefano Moro, Anna Maria Pugliese, Stephanie Federico, Giampiero Spalluto, Tatiana Da Ros   +12 more
wiley   +1 more source

Cantharidin attenuates the anti-β-adrenergic or anti-histaminergic or anti-serotoninergic effect of A₁-adenosine receptor stimulation in the isolated human atrium. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Schwarz R, Hofmann B, Kirchhefer U, Neumann J, Gergs U.   +4 more
europepmc   +1 more source

Inhibition of protein phosphatases attenuates A₁-adenosine receptor-stimulation induced negative inotropic effects of cAMP-increasing agents in the isolated human atrium. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Schwarz R, Hofmann B, Gergs U, Neumann J.   +3 more
europepmc   +1 more source

Cyclic azapeptide CD36 ligand attenuates cardiac injury and reduces long‐chain fatty acid accumulation after myocardial ischemia–reperfusion in mice

FEBS Open Bio, Volume 16, Issue 10, Page 1958-1973, October 2026.
In a murine model of myocardial ischemia and reperfusion (MI/R), the CD36 azapeptide ligand MPE‐298 reduces cardiac injury and transiently lowers left ventricular long‐chain fatty acids (LCFAs) accumulation 3 h after reperfusion, accompanied by a decrease of oxidative stress and inflammation‐associated genes' expression in the heart and adipose tissue.
Jade Gauvin, Naghme Radmannia, David N. Huynh, Liliane Ménard, Caroline Daneault, Maïté Veilleux, Ahsanullah Ahsanullah, André C. Carpentier, William D. Lubell, Matthieu Ruiz, Huy Ong, Sylvie Marleau, Simon‐Pierre Gravel   +12 more
wiley   +1 more source

Cantharidin and sodium fluoride attenuate the negative inotropic effect of the A₁-adenosine receptor agonist N⁶-(R)-phenylisopropyl adenosine in isolated human atria. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Schwarz R, Hofmann B, Gergs U, Neumann J.   +3 more
europepmc   +1 more source

A Supramolecular Thermal Switch for Precision Pyroptosis via Host−Guest Recognition and Electrostatic Interactions

Advanced Science, Volume 13, Issue 57, 14 October 2026.
A supramolecular pyroptotic thermal switch encapsulates I3− within β‐cyclodextrin (β‐CD) and undergoes CaCO3 mineralization. Upon lysosomal acidification, CaCO3 is degraded, releasing Ca2+ and I3−. Concurrently, BODIPY activation converts I3− into I2, inducing oxidative stress and Ca2+ overload, which together trigger caspase‐3/GSDME‐mediated ...
Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi   +8 more
wiley   +1 more source

Metabolic Structure: A Paradigm Revisited in Light of the Fundamental Parameters of Living Systems

BioEssays, Volume 48, Issue 10, October 2026.
Metabolism is redefined as a dynamic thermodynamic field shaped by six fundamental parameters (time, water, entropy, quantum effects, space, and electrostatics) rather than fixed genetic architecture. Case studies from enzyme kinetics to cancer cell differentiation show metabolic states, not structure alone, determine flux and control, and can be ...
Jacques Fantini
wiley   +1 more source

Learning and memory function preserved by delayed A₁ adenosine receptor agonist treatment following soman intoxication in rats and a humanized esterase mouse model. [PDF]

Neuropharmacology
Harkins J, Langston J, Keith ZM, Munoz C, Acon-Chen C, Shih TM.   +5 more
europepmc   +1 more source

Brewing Anxiety: Caffeine‐Induced Thigmotaxis in Zebrafish Larvae

Brain and Behavior, Volume 16, Issue 10, October 2026.
ABSTRACT Background Thigmotaxis, or edge preference, is widely used as a measure of anxiety in vertebrate model systems. However, variability in this behavior limits its utility as a scalable measure for anxiolytic drug discovery. In the current study, we examine caffeine‐induced thigmotaxis, using 5‐day‐old zebrafish larvae as a model system.
Rishi Rai, Thais Del Rosario Hernandez, Robbert Creton   +2 more
wiley   +1 more source