Results 11 to 20 of about 379,625 (351)

Curcumin ameliorates lipid metabolic disorder and cognitive dysfunction via the ABCA1 transmembrane transport system in APP/PS1 double transgenic mice

Journal of Integrative Neuroscience, 2021
The disorder of lipid metabolism, especially cholesterol metabolism, can promote Alzheimer’s Disease. Curcumin can ameliorate lipid metabolic disorder in the brain of Alzheimer’s Disease patients, while the mechanism is not clear.
Mingyuan Tian, Fanlin Zhou, Zhipeng Teng, Chen Wang, Xiong Zhang, Yangyang Wang, Yu Li   +6 more
doaj   +1 more source

Suppression of annexin A1 and its receptor reduces herpes simplex virus 1 lethality in mice.

PLoS Pathogens, 2022
Herpes simplex virus 1 (HSV-1)-induced encephalitis is the most common cause of sporadic, fatal encephalitis in humans. HSV-1 has at least 10 different envelope glycoproteins, which can promote virus infection.
Li-Chiu Wang, Shang-Rung Wu, Hui-Wen Yao, Pin Ling, Guey-Chuen Perng, Yen-Chi Chiu, Sheng-Min Hsu, Shun-Hua Chen   +7 more
doaj   +1 more source

EPHA1 (EPH receptor A1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on EPHA1 (EPH receptor A1), with data on DNA, on the protein encoded, and where the gene is implicated.
Stringer, B, Herath, N, Duffy, S, Coulthard, M, Boyd, A   +4 more
openaire   +2 more sources

Adenosine A1 receptor activation mediates the developmental shift at layer 5 pyramidal cell synapses and is a determinant of mature synaptic strength [PDF]

, 2013
During the first postnatal month glutamatergic synapses between layer 5 pyramidal cells in the rodent neocortex switch from an immature state exhibiting high probability of neurotransmitter release, large unitary amplitude and synaptic depression to a ...
Dunwiddie TV, Magnus J. E. Richardson, Mark J. Wall, Michael I. Kerr   +3 more
core   +1 more source

Rapid Eye Movement Sleep Deprivation Combined With Fluoxetine Protects Against Depression-Induced Damage and Apoptosis in Rat Hippocampi via A1 Adenosine Receptor

Frontiers in Psychiatry, 2021
Background: Rapid eye movement sleep deprivation (REMSD) and fluoxetine affect depression, yet the detailed molecular mechanisms were not clear.Methods: Rat depression chronic unpredictable stress was constructed, and the body weight of rats was measured.
Xuan Ju, Shengdong Wang, Pan Yan, Chunyan Zhu, Xiwen Hu, Jiezheng Dong, Zhonglin Tan   +6 more
doaj   +1 more source

Alcohol-related expectancies are associated with the D2 dopamine receptor and GABAa receptor B3 subunit genes [PDF]

, 2004
Molecular genetic research has identified promising markers of alcohol dependence, including alleles of the D2 dopamine receptor (DRD2) and the GABAA receptor ￢3 subunit (GABRB3) genes.
Bandura, Bandura, Bau, Berman, Berridge, Blomqvist, Blum, Bruce R Lawford, Christiansen, Cohen, Comings, Connor, Connor, David, Davies, Depue, DiChiara, DiChiara, DiChiara, DiChiara, Dimitrov, Duan, Dudek, Ernest P Noble, Feeney, Gelernter, Gerald F.X Feeney, Goldman, Grandy, Greenfield, Gurling, Hitzemann, Hollerman, Ikemoto, Jönsson, Kidd, Knight, Laruelle, Lawford, Lawford, Lawford, Lawford, Long, Luddens, Madrid, Maldonado, McCarthy, McCarthy, Miller, Monti, Mutirangura, Neiswanger, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noble, Noone, Ott, Pato, Persico, Pohjalainen, Robinson, Ross McD Young, Schultz, Schultz, Selzer, Silvestri, Spitz, Terry Ritchie, Thanos, Thompson, Uhl, Vernon, Vik, Volkow, Volkow, Wells-Parker, Williams, Wilson, Wise, Young, Young, Young, Young   +87 more
core   +2 more sources

Scavenger receptor A1 participates in uptake of Leptospira interrogans serovar Autumnalis strain 56606v and inflammation in mouse macrophages

Emerging Microbes and Infections, 2021
Leptospirosis, caused by pathogenic Leptospira species, has emerged as a widespread zoonotic disease worldwide. Macrophages mediate the elimination of pathogens through phagocytosis and cytokine production.
Yanchun Wang, Xia Fan, Lin Du, Boyu Liu, Haihan Xiao, Yan Zhang, Yunqiang Wu, Fuli Liu, Yung-Fu Chang, Xiaokui Guo, Ping He   +10 more
doaj   +1 more source

A population of immature cerebellar parallel fibre synapses are insensitive to adenosine but are inhibited by hypoxia [PDF]

, 2011
The purine adenosine plays an important role in a number of physiological and pathological processes and is neuroprotective during hypoxia and ischemia.
Atterbury, Alison, Wall, Mark J.
core   +1 more source

Adenosine A1 Receptor-Mediated Attenuation of Reciprocal Dendro-Dendritic Inhibition in the Mouse Olfactory Bulb

Frontiers in Cellular Neuroscience, 2018
It is well described that A1 adenosine receptors inhibit synaptic transmission at excitatory synapses in the brain, but the effect of adenosine on reciprocal synapses has not been studied so far.
Kristina Schulz, Natalie Rotermund, Katarzyna Grzelka, Jan Benz, Christian Lohr, Daniela Hirnet   +5 more
doaj   +1 more source

Rolofylline, an adenosine A1−receptor antagonist, in acute heart failure [PDF]

, 2010
Background: Worsening renal function, which is associated with adverse outcomes, often develops in patients with acute heart failure. Experimental and clinical studies suggest that counterregulatory responses mediated by adenosine may be involved. We
Bloomfield, Daniel M, Cleland, John G F, Cotter, Gad, DeLucca, Paul, Dittrich, Howard C, Fu, Michael,, Givertz, Michael M, Mansoor, George A, Massie, Barry M, Metra, Marco, O'Connor, Christopher M, Ponikowski, Piotr, Salerno, Christina M, Teerlink, John R, Voors, Adriaan, Weatherley, Beth Davison   +15 more
core   +1 more source