Results 131 to 140 of about 66,837 (297)

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

Edema Toxin Acts as an Adjuvant for Mucosal Immune Responses to Nasally Administered Vaccine Antigens

, 2006
International audienceAnthrax edema toxin (EdTx) is an AB-type toxin that binds to anthrax toxin receptors on target cells via the binding subunit, protective Ag (PA). Edema factor, the enzymatic A subunit of EdTx, is an adenylate cyclase.
Leppla, Stephen, Boyaka, Prosper, Alexandra Duverger, Angela Tafaro, Mcghee, Jerry, Prosper N. Boyaka, van Ginkel, Frederick, Kiyono, Hiroshi, Hiroshi Kiyono, Jerry R. McGhee, Stephen H. Leppla, Duverger, Alexandra, Frederick W. van Ginkel, Dejean de la Batie, Romy, Fujihashi, Kohtaro, Raymond J. Jackson, Tafaro, Angela, Romy Fischer, Kohtaro Fujihashi, Jackson, Raymond   +19 more
core   +1 more source

Ultrasound‐Activated Bifunctional Piezoelectric Hydrogel Dressings Promote Infected Wound Healing via Regulating Angiogenesis and Lymphangiogenesis

Advanced Science, EarlyView.
This study developed a double‐network hydrogel with piezoelectric properties, exhibiting excellent antibacterial activity and promoting fibroblast migration, angiogenesis, and lymphangiogenesis through piezoelectric stimulation, thereby accelerating the healing of infected chronic wounds.
Xiang Li, Zhen Ding, Zhihua Liu, Hao Chen, Jianyang Shan, Yanxuan Shao, Yaling Yu, Gen Wen   +7 more
wiley   +1 more source

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Toxin-membrane interactions of Pasteurella multocida toxin and homologous domains [PDF]

, 2014
Toxin-membrane interactions are poorly understood on the molecular level due to the inherent difficulty of crystallizing membrane protein complexes and the large size (>50 kDa) of most functional AB or MARTX protein toxins.
Brothers, Michael
core  

Four distinct structural domains in Clostridium difficile toxin B visualized using SAXS.

, 2010
Clostridium difficile is a nosocomial bacterial pathogen causing antibiotic-associated diarrhea and fatal pseudomembranous colitis. Key virulence factors are toxin A and toxin B (TcdB), two highly related toxins that are members of the large clostridial ...
von Eichel-Streiber, C, Fairweather, NF, Swain, GV, von Eichel-Streiber, Christoph, Albesa-Jove, D., Vasisht, N, von Eichel-Streiber, C., Swain, Gemma V, Braun, Veit, Lim, J, Vasisht, N., Lim, Jenson, Haire, L. F., Brown, KA, Lim, J., Bertrand, T., Albesa-Jove, David, Fairweather, Neil F, Carpenter, E. P., Zhang, J., Carpenter, EP, Svergun, Dmitri I, Swain, G. V., Braun, V, Braun, V., Svergun, D. I., Fairweather, N. F., Bertrand, T, Haire, Lesley F, Brown, Katherine A, Lange, A., Brown, K. A., Carpenter, Elizabeth, Lange, A, Albesa-Jové, D, Svergun, DI, Vasisht, Nishi, Haire, LF, Lange, Anton, Zhang, Jiancheng, Bertrand, Thomas, Carpenter, Elisabeth P, Zhang, J   +42 more
core   +1 more source

Characterization of Rabbit Polyclonal Sera against Recombinant Shiga Toxin and its Subunits for Detection of Stx-Producing E. coli

Iranian Journal of Allergy, Asthma and Immunology, 2011
Shiga toxin (Stx) is the principal virulence factor of Shigatoxigenic Escherichia coli (STEC), a food-born pathogen associated disease with uncomplicated diarrhea or the hemolytic-uremic syndrome.
Mana Oloomi, Saeid Bouzari
doaj  

The Development and Pilot Clinical Study of CD147 Targeted Antagonistic Peptide Probe for Tumor Imaging

Advanced Science, EarlyView.
This study establishes [68Ga]Ga‐DOTA‐AP9 as a first‐in‐human CD147‐targeted PET tracer with favorable safety and specific tumor uptake. Tracer accumulation correlates with CD147 expression in patients, enabling noninvasive quantification of CD147‐positive malignancies.
Xiaokun Ma, Rui Guo, Dongfeng Niu, Yufei Song, Zhenyao Zhang, Xiangxi Meng, Lili Mao, Haifeng Huang, Hua Zhu, Zhi Yang, Teli Liu   +10 more
wiley   +1 more source

Extended plant protection by an epiphytic Pseudomonas sp derivative carrying the cry9Aa gene from Bacillus thuringiensis galleriae against the pine processionary moth Thaumetopoea pityocampa

, 2006
A strain of Pseudomonas sp. isolated from the phyllosphere of Pinus nigra in northern Italy was used for the introduction and high expression level of the gene encoding the Cry9Aa entomocidal toxin from Bacillus thuringiensis spp. galleriae.
SQUARTINI, ANDREA, FILIPPINI, RACHELE, SHEVELEV AB, BATTISTI, ANDREA, ALBERGHINI, SARA   +4 more
core  

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source