Results 261 to 270 of about 66,837 (297)

Bacterial AB toxins and host–microbe interactions

2022
AB toxins are protein virulence factors secreted by many bacterial pathogens, contributing to the pathogenicity of the cognate bacteria. AB toxins consist of two functionally distinct components: the enzymatic "A" component for pathogenicity and the receptor-binding "B" component for toxin delivery.
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Retrograde trafficking of AB₅ toxins: mechanisms to therapeutics.

Journal of molecular medicine (Berlin, Germany), 2014
Bacterial AB5 toxins are a clinically relevant class of exotoxins that include several well-known members such as Shiga, cholera, and pertussis toxins. Infections with toxin-producing bacteria cause devastating human diseases that affect millions of individuals each year and have no definitive medical treatment.
Somshuvra, Mukhopadhyay, Adam D, Linstedt   +1 more
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AB5 toxins: structures and inhibitor design

Current Opinion in Structural Biology, 2000
High-resolution crystal structures of AB(5) toxins in their native form or in complex with a variety of ligands have led to the structure-based design and discovery of inhibitors targeting different areas of the toxins. The most significant progress is the development of highly potent multivalent ligands that block binding of the toxins to their ...
E, Fan, E A, Merritt, C L, Verlinde, W G, Hol   +3 more
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Ab InitioStructure Determination and Refinement of a Scorpion Protein Toxin

Acta Crystallographica Section D Biological Crystallography, 1997
The structure of toxin II from the scorpion Androctonus australis Hector has been determined ab initio by direct methods using SnB at 0.96 A resolution. For the purpose of this structure redetermination, undertaken as a test of the minimal function and the SnB program, the identity and sequence of the protein was withheld from part of the research team.
G D, Smith, R H, Blessing, S E, Ealick, J C, Fontecilla-Camps, H A, Hauptman, D, Housset, D A, Langs, R, Miller   +7 more
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15 Membrane translocation by bacterial AB toxins

2002
Publisher Summary This chapter presents some of the basic experimental assays that have been developed or used in laboratories for the study of cholera and related E. coli heat labile enterotoxins, diphtheria toxin, and anthrax toxins. The chapter emphasizes on the importance of experimental systems that provide a high degree of temporal resolution ...
Kamran Badizadegan, R.John Collier, Wayne I. Lencer   +2 more
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Purification and some properties ofClostridium botulinumtype AB toxin

FEMS Microbiology Letters, 1986
The progenitor toxin of Clostridium botulinum type AB was purified; both large-sized (L) and medium-sized (M) toxins were found. The toxicity of M toxin increased by about 10-fold upon trypsinization; the increase was due mostly to type B toxin and a little to type A toxin.
Genji Sakaguchi, Sumiko Sakaguchi, Shunji Kozaki, Motohide Takahashi   +3 more
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A Cell-Based Fluorescent Assay to Detect the Activity of AB Toxins that Inhibit Protein Synthesis

2017
Many AB toxins elicit a cytotoxic effect involving the inhibition of protein synthesis. In this chapter, we describe a simple cell-based fluorescent assay to detect and quantify the inhibition of protein synthesis. The assay can also identify and characterize toxin inhibitors.
Cherubin, Patrick, Quiñones, Beatriz, Elkahoui, Salem, Yokoyama, Wallace, Teter, Ken   +4 more
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Multivalent Inhibition of AB ₅ Toxins

Journal of the American Chemical Society, 2001
J M, Gargano, T, Ngo, J Y, Kim, D W, Acheson, W J, Lees   +4 more
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