Results 181 to 190 of about 21,197 (211)
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The influence of ABCB1 polymorphism C3435T on the pharmacokinetics of silibinin
Journal of Clinical Pharmacy and Therapeutics, 2015Silibinin (Silybin), a major constituent of the milk thistle, is commonly used to treat chronic liver disease in some countries. It has been reported to inhibit the transport activity of ABCB1. This study was carried out to determine whether ABCB1 C3435T polymorphism influenced the pharmacokinetics of silibinin contained in silymarin capsules.Twenty ...
Z R, Tan +6 more
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Promoter polymorphisms and allelic imbalance in ABCB1 expression
Pharmacogenetics and Genomics, 2007The ABCB1 (MDR1) gene, encoding the transporter P-glycoprotein, is known to act on a broad range of prescription medicines. For this reason a large number of studies have assessed the functional consequences of variation in this gene. Particular attention has focused on the ABCB1_3435C>T polymorphism, an exonic variant resulting in a synonymous change.
Loeuillet, C +12 more
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Genetic Polymorphisms in ABCB1 Influence the Pharmacodynamics of Tacrolimus
Therapeutic Drug Monitoring, 2013Tacrolimus has a large interindividual pharmacokinetic variability, and quantification of its effect is difficult. It is a substrate of ABCB1, an efflux pump expressed more on CD8 T cells than on CD4 T cells. The ABCB1 3435C>T single-nucleotide polymorphism (SNP) has been associated with interindividual differences in ABCB1 activity and may influence ...
Vafadari, Ramin +7 more
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Clinical Aspects of the MDR1 (ABCB1) Gene Polymorphism
Therapeutic Drug Monitoring, 2004Transporter proteins, in particular P-glycoprotein (Pgp), are important determinants in absorption, tissue targeting, and elimination of drugs. In addition to physiological and environmental factors, its expression and function are modified by genetic polymorphisms of the MDR1 gene.
Michel, Eichelbaum +2 more
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Association of a polymorphism in the ABCB1 gene with Parkinson's disease
Parkinsonism & Related Disorders, 2009The ATP-binding cassette, sub-family B, member 1 (ABCB1) gene encoding the protein P-glycoprotein (P-gp) has been implicated in the pathophysiology of Parkinson's disease (PD) due to its role in regulating transport of endogenous molecules and exogenous toxins.
Marie, Westerlund +8 more
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ABCB1 single nucleotide polymorphisms in the Brazilian population
Molecular Biology Reports, 2009The ABCB1/MDR-1 gene, which encodes P-glycoprotein, is highly polymorphic. We analyzed 278 healthy Brazilian individuals through PCR-RFLP to identify ABCB1 variants and determine the genotypic and allelic frequencies. Genotypic frequencies for C1236T (rs1128503) were 0.31 for CC, 0.60 for CT and 0.09 for TT and allelic frequencies were 0.61 and 0.39 ...
Marcos Antonio Mauricio, Scheiner +2 more
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Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1
Proceedings of the National Academy of Sciences of the United States of America, 2020Amer Alam +2 more
exaly
Role of ABCB1 C3435T in Platinum-based Therapy
Archives of Medical Research, 2012P. Pellegrino, D. Cattaneo, E. Clementi
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No Influence of ABCB1 Haplotypes on Methadone Dosage Requirement
Clinical Pharmacology & Therapeutics, 2008Crettol, S +7 more
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