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ABCB1, also known as MDR1, is a gene that encodes P-glycoprotein (P-gp), a membrane-associated ATP-dependent transporter. P-gp is widely expressed in many healthy tissues—in the gastrointestinal tract, liver, kidney, and at the blood–brain ...
Andrew L Hong, Katie T Skinner
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Cryo-EM structures reveal distinct mechanisms of inhibition of the human multidrug transporter ABCB1
Proceedings of the National Academy of Sciences of the United States of America, 2020Amer Alam, Kaspar P Locher, Naoya Fujita
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Tepotinib reverses ABCB1-mediated multidrug resistance in cancer cells
Biochemical Pharmacology, 2019Jian-Ye Zhang +2 more
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Clinical Significance of ABCB1 in Acute Myeloid Leukemia: A Comprehensive Study
Cancers, 2019Adeline Barthélémy +2 more
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Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells
International Journal of Molecular Sciences, 2020Linguo Zhao, Dong-Hua Yang, Jingqiu Wang
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ABCB1 polymorphisms are Associated with Clozapine Plasma Levels in Psychotic Patients
Pharmacogenomics, 2009Liliana Dell'Osso +2 more
exaly
A novel screening strategy to identify ABCB1 substrates and inhibitors
Naunyn-Schmiedeberg's Archives of Pharmacology, 2008Oliver von Richter, PhD FCP +2 more
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