Results 231 to 240 of about 108,976 (291)

Senolytics and exercise: Dual modalities for rejuvenating muscle

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican   +4 more
wiley   +1 more source

Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière   +6 more
wiley   +1 more source

Evaluation of Enzyme Inhibition and Kinetic Profiles of Origanum Essential Oils on Metabolic and Central Nervous System Targets

open access: yesNatural Sciences, Volume 6, Issue 3, July 2026.
The essential oils of three Origanum species were chemically characterized and evaluated for their antioxidant and enzyme inhibitory activities. The different compositions confer selective bioactivities: O. vulgare exhibits good antioxidant and α‐glucosidase inhibitory activity, O. majorana shows promising tyrosinase inhibition, and O.
Giuseppe Amato   +6 more
wiley   +1 more source

Integrated Orbitrap‐HRMS and Chemometric Profiling Reveals Metabolite Diversity and Antioxidant Signatures in Cerrado Eugenia Fruits

open access: yesAnalytical Science Advances, Volume 7, Issue 1, June 2026.
ABSTRACT Fruits from the Brazilian Cerrado, such as pitanga (Eugenia uniflora), jambolao (E. jambolana) and murta (E. punicifolia), are recognized for their nutritional and therapeutic potential, largely due to their phenolic‐rich profiles. However, systematic studies integrating high‐resolution mass spectrometry (HRMS) with chemometric tools to ...
Alexandre W. V. Nascimento   +8 more
wiley   +1 more source

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