Results 31 to 40 of about 1,222 (132)

Major Advances in Monkeypox Vaccine Research and Development – An Update

Journal of Pure and Applied Microbiology, 2022
Monkeypox (MPX) is a zoonotic disease that is endemic to the western and central regions of Africa and it is caused by monkeypox virus (MPXV), which is classified as a member of the Poxviridae family, specifically the Chordopoxvirinae subfamily, and the ...
Deepak Chandran, V.G. Nandanagopal, Malu Gopan, K. Megha, C.R. Hari Sankar, M.K. Muhammad Aslam, V. Vishnu Savanth, M. Pran, Firzan Nainu, Mohd. Iqbal Yatoo, Mohammad Ebad Ur Rehman, Hitesh Chopra, Talha Bin Emran, Abhijit Dey, Anil K. Sharma, AbdulRahman A. Saied, Kuldeep Dhama   +16 more
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Human monkeypox: history, presentations, transmission, epidemiology, diagnosis, treatment, and prevention

Frontiers in Medicine, 2023
Human monkeypox is a zoonotic infection that is similar to the diseases caused by other poxviruses. It is endemic among wild rodents in the rainforests of Central and Western Africa, and can be transmitted via direct skin contact or mucosal exposure to ...
Mahdi Zahmatyar, Mahdi Zahmatyar, Asra Fazlollahi, Asra Fazlollahi, Alireza Motamedi, Maedeh Zolfi, Fatemeh Seyedi, Seyed Aria Nejadghaderi, Seyed Aria Nejadghaderi, Mark J. M. Sullman, Mark J. M. Sullman, Reza Mohammadinasab, Ali-Asghar Kolahi, Shahnam Arshi, Saeid Safiri, Saeid Safiri   +15 more
doaj   +1 more source

ACAM2000 clonal Vero cell culture vaccinia virus (New York City Board of Health strain) – a second-generation smallpox vaccine for biological defense [PDF]

International Journal of Infectious Diseases, 2004
The threat of smallpox as a biological weapon has spurred efforts to create stockpiles of vaccine for emergency preparedness. In lieu of preparing vaccine in animal skin (the original method), we cloned vaccinia virus (New York City Board of Health strain, Dryvax by plaque purification and amplified the clone in cell culture.
Monath, Thomas P., Caldwell, Joseph R., Mundt, Wolfgang, Fusco, Joan, Johnson, Casey S., Buller, Mark, Liu, Jian, Gardner, Bridget, Downing, Greg, Blum, Paul S., Kemp, Tracy, Nichols, Richard, Weltzin, Richard   +12 more
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Single immunization with recombinant ACAM2000 vaccinia viruses expressing the spike and the nucleocapsid proteins protect hamsters against SARS-CoV-2 caused clinical disease [PDF]

, 2021
SUMMARY Increasing cases of SARS-CoV-2 breakthrough infections from immunization with predominantly spike protein based COVID-19 vaccines highlight the need for alternative vaccines using different platforms and/or antigens. In this study, we expressed SARS-CoV-2 spike and nucleocapsid proteins in a novel vaccinia virus ACAM2000 ...
Yvon Deschambault, Jessie Lynch, Bryce Warner, Kevin Tierney, Denise Huynh, Robert Vendramelli, Nikesh Tailor, Kathy Frost, Stephanie Booth, Babu Sajesh, Kyle LeBlanc, Christine Layne, Lisa Lin, Daniel Beniac, Michael Carpenter, David Safronetz, Xuguang Li, Darwyn Kobasa, Jingxin Cao   +18 more
openaire   +1 more source

Clinical Strategies and Therapeutics for Human Monkeypox Virus: A Revised Perspective on Recent Outbreaks

Viruses, 2023
An enveloped double-stranded DNA monkeypox virus (MPXV) is a causative agent of the zoonotic viral disease, human monkeypox (HMPX). MPXV belongs to the genus Orthopoxviridae, a family of notorious smallpox viruses, and so it shares similar clinical ...
Nilanjan Ghosh, Leena Chacko, Jayalakshmi Vallamkondu, Tanmoy Banerjee, Chandrima Sarkar, Birbal Singh, Rajkumar Singh Kalra, Jasvinder Singh Bhatti, Ramesh Kandimalla, Saikat Dewanjee   +9 more
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The Global Monkeypox (Mpox) Outbreak: A Comprehensive Review

Vaccines, 2023
Monkeypox (Mpox) is a contagious illness that is caused by the monkeypox virus, which is part of the same family of viruses as variola, vaccinia, and cowpox.
Shriyansh Srivastava, Sachin Kumar, Shagun Jain, Aroop Mohanty, Neeraj Thapa, Prabhat Poudel, Krishna Bhusal, Zahraa Haleem Al-qaim, Joshuan J. Barboza, Bijaya Kumar Padhi, Ranjit Sah   +10 more
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Human Antibody Responses to the Polyclonal Dryvax Vaccine for Smallpox Prevention Can Be Distinguished from Responses to the Monoclonal Replacement Vaccine ACAM2000 [PDF]

Clinical and Vaccine Immunology, 2014
ABSTRACT Dryvax (Wyeth Laboratories, Inc., Marietta, PA) is representative of the vaccinia virus preparations that were previously used for preventing smallpox. While Dryvax was highly effective, the national supply stocks were depleted, and there were manufacturing concerns regarding sterility and the clonal heterogeneity of the vaccine ...
Christine, Pugh, Sarah, Keasey, Lawrence, Korman, Phillip R, Pittman, Robert G, Ulrich   +4 more
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The current and future landscape of smallpox vaccines

Global Biosecurity, 2019
The potential use of smallpox as a weapon for bioterrorism has created a need for more and better smallpox vaccines. The first generation vaccines such as Dryvax were produced by crude methods that would not allow licensure today.
J. Michael Lane
doaj   +1 more source

Immunogenicity and Safety of Modified Vaccinia Ankara (MVA) Vaccine—A Systematic Review and Meta-Analysis of Randomized Controlled Trials

Vaccines, 2023
Prevention of mpox has become an important public health interest. We aimed to evaluate the safety and immunogenicity of the Modified Vaccinia Ankara (MVA) vaccine. We conducted a systematic review and meta-analysis of randomized-controlled trials (RCTs)
Lior Nave, Ili Margalit, Noam Tau, Ido Cohen, Dana Yelin, Florian Lienert, Dafna Yahav   +6 more
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Vaccination for Monkeypox Virus Infection in Humans: A Review of Key Considerations

Vaccines, 2022
Monkeypox virus infection in humans (MVIH) is currently an evolving public health concern given that >3000 MVIH cases have been reported in >50 countries globally, and the World Health Organization declared monkeypox a global health emergency on 23 July ...
Kay Choong See
doaj   +1 more source