Results 21 to 30 of about 1,222 (132)

Interferon α/β Decoy Receptor Encoded by a Variant in the Dryvax Smallpox Vaccine Contributes to Virulence and Correlates with Severe Vaccine Side Effects

mBio, 2022
Although providing long-lasting immunity, smallpox vaccination was associated with local and systemic reactions and rarely with severe complications, including progressive vaccinia and postvaccinia encephalitis. As the Dryvax smallpox vaccine consists of
Ruikang Liu, Jeffrey L. Americo, Patricia L. Earl, Jack Villani, Catherine A. Cotter, Bernard Moss   +5 more
doaj   +1 more source

Preventing the Next Pandemic: Is Live Vaccine Efficacious against Monkeypox, or Is There a Need for Killed Virus and mRNA Vaccines?

Vaccines, 2022
(1) Background: The monkeypox virus (MPV) is a double-stranded DNA virus belonging to the Poxviridae family, Chordopoxvirinae subfamily, and Orthopoxvirus genus.
Abdelaziz Abdelaal, Abdullah Reda, Basant Ismail Lashin, Basant E. Katamesh, Aml M. Brakat, Balqees Mahmoud AL-Manaseer, Sayanika Kaur, Ankush Asija, Nimesh K. Patel, Soney Basnyat, Ali A. Rabaan, Saad Alhumaid, Hawra Albayat, Mohammed Aljeldah, Basim R. Al Shammari, Amal H. Al-Najjar, Ahmed K. Al-Jassem, Sultan T. AlShurbaji, Fatimah S. Alshahrani, Ahlam Alynbiawi, Zainab H. Alfaraj, Duaa H. Alfaraj, Ahmed H. Aldawood, Yub Raj Sedhai, Victoria Mumbo, Alfonso J. Rodriguez-Morales, Ranjit Sah   +26 more
doaj   +1 more source

Features of the pathogenesis, epidemiology, diagnostics, approaches to the treatment and prevention of small pox, the current state of the problem in Ukraine and the world

Актуальні проблеми сучасної медицини, 2022
Introduction. Monkey pox is an anthropozoonous disease caused by orthopoxvirus, characterized by fever, general intoxication and skin rash, in some cases it can lead to fatal consequences; an infectious disease covered by international health regulations
Oksana Bobrova, Nataliia Mikhanovska, Krystyna Kryvonos   +2 more
doaj   +1 more source

Monkeypox in human pregnancy: an overview

AJOG Global Reports, 2022
Monkeypox is a viral zoonosis caused by the monkeypox virus, an enveloped, double-stranded DNA virus belonging to the Orthopoxvirus genus in the Poxviridae family. Monkeypox has become a disease of global public health significance.
Sulaiman Muhammad Daneji, MBBS, FWACS, Aliyu Aminu, MBBS, FMCPath, Awwal Musa Borodo, MBBS, MSc, FWACP, FMCPath, Farouq Muhammad Dayyab, MBBS, MPH, FMCP   +3 more
doaj   +1 more source

A brief on new waves of monkeypox and vaccines and antiviral drugs for monkeypox

Journal of Microbiology, Immunology and Infection, 2022
Monkeypox virus (MPXV), genetic closely linked to the notorious variola (smallpox) virus, currently causes several clusters and outbreaks in the areas outside Africa and is noted to be phylogenetically related to the West African clade.
Yuan-Pin Hung, Ching-Chi Lee, Jen-Chieh Lee, Chun-Wei Chiu, Po-Ren Hsueh, Wen-Chien Ko   +5 more
doaj   +1 more source

Monkeypox: An Uncommon Re-emerging Virus- Threat to Mankind [PDF]

Journal of Clinical and Diagnostic Research, 2023
Monkeypox Virus (MPV) causes rare zoonotic illness. The Central African (or Congo Basin) clade and the West African clade are its two genetic subgroups, of which Central African subgroup is more lethal.
Ashwini Arun Mankar, Suvarna Vaibhav Sande, Priyanka Purushottam Chaubey   +2 more
doaj   +1 more source

Vaccinia-Virus-Based Vaccines Are Expected to Elicit Highly Cross-Reactive Immunity to the 2022 Monkeypox Virus

Viruses, 2022
Beginning in May 2022, a novel cluster of monkeypox virus infections was detected in humans. This virus has spread rapidly to non-endemic countries, sparking global concern.
Syed Faraz Ahmed, Muhammad Saqib Sohail, Ahmed Abdul Quadeer, Matthew R. McKay   +3 more
doaj   +1 more source

Side-by-side comparison of gene-based smallpox vaccine with MVA in nonhuman primates. [PDF]

PLoS ONE, 2012
Orthopoxviruses remain a threat as biological weapons and zoonoses. The licensed live-virus vaccine is associated with serious health risks, making its general usage unacceptable. Attenuated vaccines are being developed as alternatives, the most advanced
Joseph W Golden, Matthew Josleyn, Eric M Mucker, Chien-Fu Hung, Peter T Loudon, T C Wu, Jay W Hooper   +6 more
doaj   +1 more source

First-in-human study of TK-positive oncolytic vaccinia virus delivered by adipose stromal vascular fraction cells

Journal of Translational Medicine, 2019
Background ACAM2000, a thymidine kinase (TK)-positive strain of vaccinia virus, is the current smallpox vaccine in the US. Preclinical testing demonstrated potent oncolytic activity of ACAM2000 against several tumor types.
Boris R. Minev, Elliot Lander, John F. Feller, Mark Berman, Bernadette M. Greenwood, Ivelina Minev, Antonio F. Santidrian, Duong Nguyen, Dobrin Draganov, Mehmet O. Killinc, Anna Vyalkova, Santosh Kesari, Edward McClay, Gabriel Carabulea, Francesco M. Marincola, Lisa H. Butterfield, Aladar A. Szalay   +16 more
doaj   +1 more source

Monkeypox: a global health emergency

Frontiers in Microbiology, 2023
Over the past 2 years, the world has faced the impactful Coronavirus Disease-2019 (COVID-19) pandemic, with a visible shift in economy, medicine, and beyond.
Ruxandra Ilinca Stilpeanu, Ruxandra Ilinca Stilpeanu, Ana Maria Stercu, Ana Maria Stercu, Andreea Lucia Stancu, Antoanela Tanca, Antoanela Tanca, Octavian Bucur, Octavian Bucur, Octavian Bucur   +9 more
doaj   +1 more source