Results 161 to 170 of about 250,937 (292)

Cofactor engineering of intracellular CoA/acetyl-CoA and its subsequent effect on isoamyl acetate production in Escherichia coli

, 2004
Traditional metabolic engineering focused on pathway manipulation strategies like amplification addition or deletion of pathway to manipulate fluxes.
Vadali, Ravishankar V.
core  

LXRα and PPARα Mediated Hepatic Lipid Metabolic Disruption Induced by the UV Filter EHMC in 2D and 3D HepaRG Cell Models

Food Safety and Health, EarlyView.
Dietary UV filter EHMC induces hepatic steatosis in HepaRG cells at noncytotoxic concentrations. Mechanistically, EHMC binds nuclear receptors (LXRα, PPARα), upregulating SREBP‐1 to accelerate fatty acid synthesis. These findings highlight the potential metabolic toxicity of widespread EHMC exposure through food sources.
Shanglin Yang, Na Li, Yingnan Han, Mei Ma   +3 more
wiley   +1 more source

Impaired Acetyl-CoA Compartmentalization Drives a Futile Lipogenic-Oxidative Cycle in N88S Seipinopathy. [PDF]

Cells
Moreira V, van Roermund CWT, Costa V, Teixeira V.   +3 more
europepmc   +1 more source

Acetyl-CoA synthase 1 mediates metabolic reprogramming to promote proliferation and metastasis of osteosarcoma. [PDF]

J Orthop Translat
He X, Luo M, Wang C, Kong L, Li J, Tan J, Chen J, Nie Y, Chen H, Zou Z, Su Z, Lin L.   +11 more
europepmc   +1 more source

Cholinergic Phenotypes of Acetyl-CoA with ATP-Citrate Lyase Link. [PDF]

Int J Mol Sci
Gul-Hinc S, Jankowska-Kulawy A, Szutowicz A.   +2 more
europepmc   +1 more source

SHH drives gastric cancer-associated fibroblast activation via ACLY-dependent acetyl-CoA metabolism and histone acetylation. [PDF]

Discov Oncol
Zhang X, Sun L, Zhang Y, Wang Y, Huang Y, Jiang Y, Wang D.   +6 more
europepmc   +1 more source

Role of cellular metabolism in epigenome rearrangement during pancreatic carcinogenesis.

reservedIl cancro al pancreas è uno dei più mortali, per cui necessita presto di nuove strategie di prevenzione e trattamento. Un ruolo chiave nella carcinogenesi pancreatica è svolto dall'enzima ACLY, che produce acetyl-CoA.
COLLADET, VITTORIA
core  

From two to one: resolving CO binding in acetyl-CoA synthase. [PDF]

Chem Sci
Poire D, Bernitzky CCM, Vaithiyanathan M, Martins BM, Lorent C, Ahamad TM, Pelmenschikov V, Sazanovich I, Greetham GM, Zebger I, Dobbek H, Mroginski MA, Horch M.   +12 more
europepmc   +1 more source

An Acetyl-CoA-Gated Metabolic Checkpoint Links Precursor Supply to Cordycepin Biosynthesis in <i>Cordyceps militaris</i>. [PDF]

Curr Issues Mol Biol
Zhang H, Yang D, Yang G, Luo S, Lu P, Xie G, Song Y, Yang J, Liu L, Fan H, Lao W, Vriesekoop F.   +11 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source