Dietary nitrate supplementation mitigates age‐related changes at the neuromuscular junction in mice
Abstract figure legend Ageing is associated with a decline in muscle mass and strength, namely sarcopenia, significantly impacting the quality of life in older individuals. Different strategies are being explored to counteract these detrimental effects. In the present study, we investigated a non‐invasive nutritional approach: the impact of 2 months of
Maira Rossi+9 more
wiley +1 more source
Structural features of the acetyl-CoA carboxylase gene: mechanisms for the generation of mRNAs with 5' end heterogeneity. [PDF]
X C Luo+3 more
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Shaoxing Huang+6 more
semanticscholar +1 more source
Cellular Senescence in Cancer: Mechanisms, Roles in Tumor Progression, and Therapeutic Implications
Senescent tumor cells in TME exhibit dual roles. “Angels” secrete SASPs/DAMPs to boost immunological clearance and antitumor immunity via MHC‐I upregulation; “Demons” produce tumor‐promoting SASPs recruiting MDSCs to drive malignancy. ABSTRACT Cellular senescence, a state of irreversible cell cycle arrest accompanied by a senescence‐associated ...
Jingrui Yan+5 more
wiley +1 more source
Determination of the quantity of acetyl CoA carboxylase by [14C]methyl avidin binding
Conditions are described under which monomeric [14C]methyl avidin binds to SDS-denatured biotin enzymes and remains bound through polyacrylamide gel electrophoresis. The location of radioactive proteins on the dried gel was determined by fluorography and
C R Roman-Lopez, J Goodson, J B Allred
doaj
The Metabolism of Coenzyme A and Its Derivatives Plays a Crucial Role in Diseases
Coenzyme A (CoA) functions as a crucial carrier of acyl groups within cells, playing a fundamental role in regulating acyl transfer reactions and participating in cellular metabolic processes.
Jumin Xie+4 more
doaj +1 more source
This study evaluated the effect of soluble dietary fiber from Ganoderma sinense on nonalcoholic fatty liver disease (NAFLD) by establishing in vitro cell and in vivo mouse models. Ganoderma sinense soluble dietary fiber (GSSDF) alleviates nonalcoholic fatty liver disease by regulating lipid metabolism and reducing oxidative stress.
Ping Shao+6 more
wiley +1 more source
Isolation of three cyclic-AMP-independent acetyl-CoA carboxylase kinases from lactating rat mammary gland and characterization of their effects on enzyme activity [PDF]
Michael R. Munday, D. Grahame Hardie
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Background and Purpose Liver X receptors (LXRs) are promising therapeutic targets for alleviating Alzheimer's disease (AD) symptoms. We assessed the impact of the semi‐synthetic LXR agonist 22‐ketositosterol on disease progression in an AD mouse model.
Nikita Martens+15 more
wiley +1 more source
Diatom triacylglycerol metabolism: from carbon fixation to lipid droplet degradation
ABSTRACT Diatoms are a prominent microalgae family that has attracted interest for its production of molecules of biotechnological interest. Their fatty acid profile is rich in health‐beneficial omega‐3 eicosapentaenoic acid (EPA). Furthermore, under nutrient‐deprived conditions, many diatom species, notably Phaeodactylum tricornutum, Thalassiosira ...
Victor Murison+3 more
wiley +1 more source