Results 121 to 130 of about 56,101 (298)

Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals

open access: yesCell Proliferation, EarlyView.
One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye   +6 more
wiley   +1 more source

Mitochondrial fatty acid beta-oxidation

open access: yesEXCLI Journal : Experimental and Clinical Sciences
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply ...
Cassandra E. Bradley   +7 more
doaj   +1 more source

Lactate and Lactylation in AKI‐to‐CKD: Epigenetic Regulation and Therapeutic Opportunities

open access: yesCell Proliferation, EarlyView.
ABSTRACT Lactate is not only a byproduct of glycolysis, but is also considered an energy source, gluconeogenic precursor, signalling molecule and protein modifier during the process of cellular metabolism. The discovery of lactylation reveals the multifaceted functions of lactate in cellular metabolism and opens new avenues for lactate‐related research.
Yi Hou   +7 more
wiley   +1 more source

Regulation of eukaryotic acetyl-CoA carboxylases

open access: yes, 2018
Many biological carboxylation reactions are catalyzed by ubiquitous biotin-dependent carboxylases. Their mechanism involves three conserved functional components; First, a biotin moiety, covalently linked to the biotin carboxyl carrier protein (BCCP) is carboxylated under ATP consumption at the biotin carboxylase (BC). Then the BCCP translocates to the
openaire   +3 more sources

Use of adjunctive glycaemic agents with vascular protective properties in individuals with type 1 diabetes: Potential benefits and risks

open access: yesDiabetes, Obesity and Metabolism, EarlyView.
Abstract Glycaemic therapy in type 1 diabetes (T1D) is focused on insulin, with the majority of studies investigating different insulin preparations, delivery devices and dosing accuracy methods. While insulin deficiency is the key mechanism for hyperglycaemia in T1D, individuals with this condition can also develop insulin resistance (IR), making ...
Ahmad M. Rajab   +2 more
wiley   +1 more source

Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

open access: yesJournal of Hepatology, 2020
J. Bates   +19 more
semanticscholar   +1 more source

FAHD1 and mitochondrial metabolism: a decade of pioneering discoveries

open access: yesThe FEBS Journal, EarlyView.
This paper reviews a decade of research on FAHD1, an important yet underappreciated enzyme in mitochondrial metabolism. FAHD1 plays a crucial role in energy production, oxidative stress regulation, and processes related to aging and overall health.
Elia Cappuccio   +9 more
wiley   +1 more source

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