Results 71 to 80 of about 56,989 (293)

Inherited metabolic epilepsies–established diseases, new approaches

open access: yesEpilepsia Open, EarlyView.
Abstract Inherited metabolic epilepsies (IMEs) represent the inherited metabolic disorders (IMDs) in which epilepsy is a prevailing component, often determining other neurodevelopmental outcomes associated with the disorder. The different metabolic pathways affected by individual IMEs are the basis of their rarity and heterogeneity.
Itay Tokatly Latzer, Phillip L. Pearl
wiley   +1 more source

Actinidia spp. (Kiwifruit): A Comprehensive Review of Its Nutraceutical Potential in Disease Mitigation and Health Enhancement

open access: yesFood Frontiers, EarlyView.
Nutraceutical Potential in Disease Mitigation and Health Enhancement of Actinidia spp. (Kiwifruit) ABSTRACT This review offers an in‐depth exploration of the Actinidia species (kiwifruit) nutritional composition, the pivotal role of its primary bioactive compounds, and their potential applications across the aforementioned health concerns. Furthermore,
Allah Rakha   +7 more
wiley   +1 more source

Platelet Acetyl-CoA Carboxylase Phosphorylation

open access: yesJACC: Basic to Translational Science, 2019
Summary: Adenosine monophosphate–activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway.
Shakeel Kautbally, MD   +23 more
doaj  

Bimodal Activation of Acetyl-CoA Carboxylase by Glutamate [PDF]

open access: yesJournal of Biological Chemistry, 2000
Acetyl-CoA carboxylase (ACC) catalyzes the formation of malonyl-CoA, an essential substrate for fatty acid biosynthesis and a potent inhibitor of fatty acid oxidation. Here, we provide evidence that glutamate may be a physiologically relevant activator of ACC.
Jerzy E. Kulpa   +3 more
openaire   +3 more sources

Acetyl-CoA carboxylase 1–dependent lipogenesis promotes autophagy downstream of AMPK

open access: yesJournal of Biological Chemistry, 2019
Autophagy, a membrane-dependent catabolic process, ensures survival of aging cells and depends on the cellular energetic status. Acetyl-CoA carboxylase 1 (Acc1) connects central energy metabolism to lipid biosynthesis and is rate-limiting for the de novo
A. Gross   +23 more
semanticscholar   +1 more source

A new method for the isolation of rat liver acetyl-CoA carboxylase.

open access: yesJournal of Lipid Research, 1981
Rat liver acetyl-CoA carboxylase has been purified to homogeneity by a new method involving polyethylene glycol precipitation, and DEAE and Sepharose 4B chromatography. The final product displays a single band on SDS polyacrylamide gel electrophoresis of
L A Witters, B Vogt
doaj  

ACCase cross-resistance in Italian ryegrass (Lolium multiflorum) sub-populations from Oregon, US

open access: yesJulius-Kühn-Archiv, 2012
ACCase-resistant Italian ryegrass (Lolium multiflorum) is one of the most troublesome weeds in US wheat production systems. This study had the objective of determining the resistance pattern of three subpopulations selected from a winter wheat field with
Barbosa Martins, Bianca Assis   +3 more
doaj   +1 more source

Crystal structure of the 500 kD yeast acetyl-CoA carboxylase holoenzyme dimer

open access: yesNature, 2015
Acetyl-CoA carboxylase (ACC) has crucial roles in fatty acid metabolism and is an attractive target for drug discovery against diabetes, cancer and other diseases.
Jia Wei, L. Tong
semanticscholar   +1 more source

LRP8 Regulates Lipid Metabolism to Stimulate Malignant Progression and Cisplatin Resistance in Bladder Cancer

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Low‐density lipoprotein receptor‐related protein 8 (LRP8) is a crucial regulator of lipid metabolism and is implicated in the development and treatment of various cancers. However, its role in bladder cancer (BCa) remains unknown. We analyzed LRP8 expression in BCa using the TCGA database and clinical samples. We manipulated LRP8 expression in
Gang‐Feng Wu   +5 more
wiley   +1 more source

Elevating acetyl-CoA levels reduces aspects of brain aging

open access: yeseLife, 2019
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121
Antonio Currais   +8 more
doaj   +1 more source

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