Results 81 to 90 of about 86,728 (368)
Advanced Science, EarlyView.This study mainly combines spatial/single‐cell transcriptomics and metabolomics to reveal LOX+ Malig‐5 as NSCLC brain metastasis‐initiating cells, forming a niche with NET‐releasing neutrophils via the NET‐KRT10 axis. The metastatic niche is involved with metabolic reprogramming, with palmitic acid serving as a key metabolite.
Bo Chen +17 more
wiley +1 more source
Frontiers in Microbiology, 2016 The family of PII signal transduction proteins (members GlnB, GlnK, NifI) plays key roles in various cellular processes related to nitrogen metabolism at different functional levels.
Waldemar Hauf +5 more
doaj +1 more source
Fatty Acid Oxidation and Meiotic Resumption in Mouse Oocytes [PDF]
, 2009 We have examined the potential role of fatty acid oxidation (FAO) in AMP-activated protein kinase (AMPK)-induced meiotic maturation. Etomoxir and malonyl CoA, two inhibitors of carnitine palmitoyl transferase-1 (CPT1), and thus FAO, blocked meiotic ...
Downs, Stephen +2 more
core +2 more sources
Phosphorylation of pea chloroplast acetyl‐CoA carboxylase [PDF]
The Plant Journal, 1999 SummaryWe have examined whether chloroplast acetyl‐CoA carboxylase is a phosphoprotein. Pea (Pisum sativum) chloroplasts were incubated in the presence of [γ‐33P]‐ATP and radiolabeled proteins were examined after immunoprecipitation with antibodies against all four known subunits of heteromeric chloroplast acetyl‐CoA carboxylase.
, Savage, , Ohlrogge
openaire +2 more sources
Advanced Science, EarlyView.NAD⁺ homeostasis maintains neuronal integrity through opposing actions of NMNAT2 and SARM1. Loss of NMNAT2 in glutamatergic neurons reprograms cortical metabolism from glucose to lipid catabolism, depletes lipid stores, and triggers inflammation and neurodegeneration.
Zhen‐Xian Niou +9 more
wiley +1 more source
Sequences of acetyl CoA carboxylase promoter for tumour necrosis factor action
Mediators of Inflammation, 1993 Tumour necrosis factor (TNF) inhibits the accumulation of acetyl CoA carboxylase (ACC) mRNA by decreasing the rate of ACC gene transcription. The ACC mRNA species found in 30A5 cells are generated from promoter II and TNF inhibits the accumulation of ...
Keerang Park +2 more
doaj +1 more source
Advanced Science, EarlyView.BioE is a new diiron oxygenase that catalyzes the conversion of long‐chain acyl groups into pimeloyl thioester, initiating biotin synthesis. The overexpression of EmBioE disrupts lipid metabolic homeostasis, requiring repressor BioL to maintain a balance between long‐chain fatty acids and biotin synthesis.
Meng Zhang +9 more
wiley +1 more source
The Regulatory Effects of Acetyl-CoA Distribution in the Healthy and Diseased Brain
Frontiers in Cellular Neuroscience, 2018 Brain neurons, to support their neurotransmitter functions, require a several times higher supply of glucose than non-excitable cells. Pyruvate, the end product of glycolysis, through pyruvate dehydrogenase complex reaction, is a principal source of ...
Anna Ronowska +7 more
doaj +1 more source
Pyrrolocin C and equisetin inhibit bacterial acetyl-CoA carboxylase.
PLoS ONE, 2020 Antimicrobial resistance is a growing global health and economic concern. Current antimicrobial agents are becoming less effective against common bacterial infections.
Erica C Larson +7 more
doaj +1 more source
Key Molecules of Fatty Acid Metabolism in Gastric Cancer
Biomolecules, 2022 Fatty acid metabolism is closely linked to the progression of gastric cancer (GC), a very aggressive and life-threatening tumor. This study examines linked molecules, such as Sterol Regulatory Element-Binding Protein 1 (SREBP1), ATP Citrate Lyase (ACLY),
Chunlei Li +4 more
doaj +1 more source