Results 131 to 140 of about 2,632,092 (318)

Regulation of AMP-activated protein kinase and acetyl-CoA carboxylase phosphorylation by palmitate in skeletal muscle cells

Journal of Lipid Research, 2006
The purpose of this study was to investigate the effects of long-chain fatty acids (LCFAs) on AMP-activated protein kinase (AMPK) and acetyl-coenzyme A carboxylase (ACC) phosphorylation and β-oxidation in skeletal muscle.
S. Fediuc, M.P. Gaidhu, R.B. Ceddia
doaj  

Elevating acetyl-CoA levels reduces aspects of brain aging

eLife, 2019
Because old age is the greatest risk factor for dementia, a successful therapy will require an understanding of the physiological changes that occur in the brain with aging. Here, two structurally distinct Alzheimer's disease (AD) drug candidates, CMS121
Antonio Currais, Ling Huang, Joshua Goldberg, Michael Petrascheck, Gamze Ates, António Pinto-Duarte, Maxim N Shokhirev, David Schubert, Pamela Maher   +8 more
doaj   +1 more source

Multi-Method Quantification of Acetyl-Coenzyme A and Further Acyl-Coenzyme A Species in Normal and Ischemic Rat Liver. [PDF]

Int J Mol Sci, 2023
Tokarska-Schlattner M, Zeaiter N, Cunin V, Attia S, Meunier C, Kay L, Achouri A, Hiriart-Bryant E, Couturier K, Tellier C, El Harras A, Elena-Herrmann B, Khochbin S, Le Gouellec A, Schlattner U.   +14 more
europepmc   +1 more source

Virtual screening and lead optimisation to identify novel inhibitors for HDAC-8 [PDF]

arXiv, 2012
Histone deacetylase (HDAC) and Histone acetyl-transferase (HAT) are enzymes that influence transcription by selectively deacetylating or acetylating the (epsilon)-amino groups of lysine located near the amino termini of core histone proteins. Over expression of HDACs noted in many forms of cancers including leukemia and breast cancer.
arxiv  

Synthesis, Biological Evaluation and Molecular Docking Studies of Piperidinylpiperidines and Spirochromanones Possessing Quinoline Moieties as Acetyl-CoA Carboxylase Inhibitors

Molecules, 2015
Acetyl-coenzyme A carboxylases (ACCs) play critical roles in the regulation of fatty acid metabolism and have been targeted for the development of drugs against obesity, diabetes and other metabolic diseases.
Tonghui Huang, Jie Sun, Qianqian Wang, Jian Gao, Yi Liu   +4 more
doaj   +1 more source

The glossyhead1 Allele of ACC1 Reveals a Principal Role for Multidomain Acetyl-Coenzyme A Carboxylase in the Biosynthesis of Cuticular Waxes by Arabidopsis[C][W][OA]

Plant Physiology, 2011
A novel mutant of Arabidopsis (Arabidopsis thaliana), having highly glossy inflorescence stems, postgenital fusion in floral organs, and reduced fertility, was isolated from an ethyl methanesulfonate-mutagenized population and designated glossyhead1 ...
Shiyou Lü, Huayan Zhao, E. P. Parsons, Changcheng Xu, D. Kosma, Xiaojin Xu, Daiyin Chao, Gregory T Lohrey, D. Bangarusamy, Guangchao Wang, R. Bressan, M. Jenks   +11 more
semanticscholar   +1 more source

Oleic acid is a potent inhibitor of fatty acid and cholesterol synthesis in C6 glioma cells

Journal of Lipid Research, 2007
Glial cells play a pivotal role in brain fatty acid metabolism and membrane biogenesis. However, the potential regulation of lipogenesis and cholesterologenesis by fatty acids in glial cells has been barely investigated.
Francesco Natali, Luisa Siculella, Serafina Salvati, Gabriele V. Gnoni   +3 more
doaj  

Acly Deficiency Enhances Myelopoiesis through Acetyl Coenzyme A and Metabolic-Epigenetic Cross-Talk. [PDF]

Immunohorizons, 2022
Greenwood DL, Ramsey HE, Nguyen PTT, Patterson AR, Voss K, Bader JE, Sugiura A, Bacigalupa ZA, Schaefer S, Ye X, Dahunsi DO, Madden MZ, Wellen KE, Savona MR, Ferrell PB, Rathmell JC.   +15 more
europepmc   +1 more source

Impact of Model‐Informed Drug Development on Drug Development Cycle Times and Clinical Trial Cost

Clinical Pharmacology &Therapeutics, EarlyView.
Model‐informed drug development (MIDD) integrates data to quantify benefit/risk informing objective drug discovery and development decisions. An additional critical benefit of MIDD is postulated to be improvement in trial and program efficiencies. While the application of MIDD has grown, there have been no clear examples across programs to demonstrate ...
Vaishali Sahasrabudhe, Timothy Nicholas, Gianluca Nucci, Cynthia J Musante, Brian Corrigan   +4 more
wiley   +1 more source

Significance of abnormal expression of fatty acid metabolic enzymes in the diagnosis of autism [PDF]

Jichu yixue yu linchuang, 2020
Objective To investigate the significance of expression level of fatty acid metabolic enzymes in the diagnosis of autism. Methods The protein content of fatty acid synthase (FASN), acetyl-CoA carboxylase (ACC), acetyl-CoA synthase 1 (AceCS1) and long ...
CHEN Jian-ling, FU Ying-mei, YU Shun-ying, CHEN Jing, DU Ya-song
doaj