Results 41 to 50 of about 83,583 (185)

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Discover Oncology, 2022
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou, Deyu Chen   +5 more
doaj   +1 more source

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

Functional responses of methanogenic archaea to syntrophic growth. [PDF]

, 2012
Methanococcus maripaludis grown syntrophically with Desulfovibrio vulgaris was compared with M. maripaludis monocultures grown under hydrogen limitation using transcriptional, proteomic and metabolite analyses.
Arkin, Adam P, Baidoo, Edward E, He, Zhili, Hendrickson, Erik L, Joachimiak, Marcin P, Keasling, Jay D, Leigh, John A, Mukhopadhyay, Aindrila, Rajeev, Lara, Redding-Johanson, Alyssa M, Stahl, David A, Stolyar, Sergey, Walker, Christopher B, Zhou, Jizhong   +13 more
core   +2 more sources

Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA.

PLoS Biology, 2023
The canonical glycolysis pathway is responsible for converting glucose into 2 molecules of acetyl-coenzyme A (acetyl-CoA) through a cascade of 11 biochemical reactions.
Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu, Jie Zhang, Jian Cheng, Qiaoyu Yang, Huanyu Chu, Xiaoyun Lu, Mengting Luo, Xiang Sheng, Yi-Heng P J Zhang, Huifeng Jiang, Yanhe Ma   +13 more
doaj   +1 more source

A novel class of CoA-transferase involved in short-chain fatty acid metabolism in butyrate-producing human colonic bacteria [PDF]

, 2005
Peer reviewedPublisher ...
Altschul, Asanuma, Ausubel, Barcenilla, Barker, Bennett, Blaut, Boynton, Buckel, Cleland, Cédric Charrier, Diez-Gonzalez, Donna Henderson, Duncan, Ewing, Ewing, Fischer, Garry J. Rucklidge, Gary J. Duncan, Gerhardt, Gordon, Harry J. Flint, Heider, Louis, Macfarlane, Mack, Martin D. Reid, Miller, Ochman, Pauline Young, Perkins, Petra Louis, Pryde, Rincon, Rustam I. Aminov, Scherf, Schweiger, Selmer, Skantar, Smith, Söhling, Sramek, Tung, Valentin, Valerie J. Russell, Walter, Wächtershäuser, Wiesenborn, Wilkins   +48 more
core   +1 more source

Profiling of cytosolic and peroxisomal acetyl-CoA metabolism in Saccharomyces cerevisiae.

PLoS ONE, 2012
As a key intracellular metabolite, acetyl-coenzyme A (acetyl-CoA) plays a major role in various metabolic pathways that link anabolism and catabolism. In the yeast Saccharomyces cerevisiae, acetyl-CoA involving metabolism is compartmentalized, and may ...
Yun Chen, Verena Siewers, Jens Nielsen
doaj   +1 more source

Breaking the Cycle, Cholesterol Cycling, and Synapse Damage in Response to Amyloid-ß [PDF]

, 2017
Soluble amyloid-β (Aβ) oligomers, a key driver of pathogenesis in Alzheimer disease, bind to cellular prion proteins (PrPC) expressed on synaptosomes resulting in increased cholesterol concentrations, movement of cytoplasmic phospholipase A2 (cPLA2) to ...
Bate, C
core   +2 more sources

Acetyl-CoA synthetase activity is enzymatically regulated by lysine acetylation using acetyl-CoA or acetyl-phosphate as donor molecule

Nature Communications
The AMP-forming acetyl-CoA synthetase is regulated by lysine acetylation both in bacteria and eukaryotes. However, the underlying mechanism is poorly understood.
Chuan Qin, Leonie G. Graf, Kilian Striska, Markus Janetzky, Norman Geist, Robin Specht, Sabrina Schulze, Gottfried J. Palm, Britta Girbardt, Babett Dörre, Leona Berndt, Stefan Kemnitz, Mark Doerr, Uwe T. Bornscheuer, Mihaela Delcea, Michael Lammers   +15 more
doaj   +1 more source

The dynamic organization of fungal acetyl-CoA carboxylase [PDF]

, 2016
Acetyl-CoA carboxylases (ACCs) catalyse the committed step in fatty-acid biosynthesis: the ATP-dependent carboxylation of acetyl-CoA to malonyl-CoA. They are important regulatory hubs for metabolic control and relevant drug targets for the treatment of ...
Hagmann, Anna, Hunkeler, Moritz, Imseng, Stefan, Maier, Timm, Stuttfeld, Edward   +4 more
core   +1 more source

Predicting the conformations of peptides and proteins in early evolution. A review article submitted to Biology Direct [PDF]

, 2008
Considering that short, mainly heterochiral, polypeptides with a high glycine content are expected to have played a prominent role in evolution at the earliest stage of life before nucleic acids were available, we review recent knowledge about ...
Milner-White, E.J., Russell, M.
core   +4 more sources