Results 61 to 70 of about 48,976 (299)

Activation of immobilized acetyl-Coenzyme A carboxylase [PDF]

Biochemical Journal, 1978
Partially purified acetyl-CoA carboxylase was covalently bound to a Sepharose 4B matrix. Although aggregation was thus prevented, the enzymic activity was stimulated by citrate and isocitrate.
A D, Landman, J, Lampert
openaire   +2 more sources

Erucic Acid, Derived by Lactobacillus Crispatus, Induces Ferroptosis in Cervical Cancer Organoids Through the PPAR‐δ Signaling Pathway

Advanced Science, EarlyView.
Utilizing PDO, cell lines and cervical cancer xenograft (CDX) models, the study demonstrate both in vitro and in vivo that the metabolite of L. crispatus, erucic acid, can modulate the proliferation, migration and invasion of cervical cancer by activating the PPAR‐δ pathway.
Qianwei Zhen, Yuexuan Xu, Ying Xu, Xiao Liu, Yuting Zhang, Dan Ye, Sai Han, Shili Liu, Youzhong Zhang   +8 more
wiley   +1 more source

Mitochondrial fatty acid beta-oxidation

EXCLI Journal : Experimental and Clinical Sciences
Peripheral artery disease (PAD) is an atherosclerotic disease impacting over 200 million individuals and the prevalence increases with age. PAD occurs when plaque builds up within the peripheral arteries, leading to reduced blood flow and oxygen supply ...
Cassandra E. Bradley, Emma Fletcher, Trevor Wilkinson, Andrew Ring, Lucas Cardona Ferrer, Dimitrios Miserlis, Pal Pacher, Panagiotis Koutakis   +7 more
doaj   +1 more source

Glut1 deficiency (G1D): Epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype

Neurobiology of Disease, 2012
Brain glucose supplies most of the carbon required for acetyl-coenzyme A (acetyl-CoA) generation (an important step for myelin synthesis) and for neurotransmitter production via further metabolism of acetyl-CoA in the tricarboxylic acid (TCA) cycle ...
Isaac Marin-Valencia, Levi B. Good, Qian Ma, Joao Duarte, Teodoro Bottiglieri, Christopher M. Sinton, Charles W. Heilig, Juan M. Pascual   +7 more
doaj   +1 more source

ARL5B Drives Esophageal Squamous Cell Carcinoma Progression via ROCK1–SREBP1‐Mediated Lipid Metabolic Reprogramming

Advanced Science, EarlyView.
Esophageal squamous cell carcinoma urgently requires new therapeutic strategies. Adenosine diphosphate‐ribosylation factor‐like protein 5B (ARL5B) is identified as a novel oncogene that remodels fatty acid metabolism through the ras homologous‐associated coiled‐coil containing protein kinase 1 (ROCK1)–sterol regulatory element‐binding protein 1 (SREBP1)
Xinyue Ma, Yanfei Sun, Hongyuan Mao, Chenhan Huang, Zerun Li, Tianzi Wang, Dizhi Jiang, Xinyu Zhang, Zhenyu Yuan, Zhihui Zhang, Bo Cheng, Ruiqing Wang, Yufeng Cheng   +12 more
wiley   +1 more source

ADA2 Forms Nuclear Condensates with GCN5 and ATP‐Citrate Lyase (ACL) to Modulate H3K9 Acetylation at Genes Functioning in Rice Meristems

Advanced Science, EarlyView.
This study unveils a novel GAA (GCN5‐ADA2‐ACL) complex that forms nuclear condensates to boost local acetyl‐CoA, facilitating histone acetylation and gene transcription in rice meristems. The research underscores the role of ADA2's disordered region in complex condensation and ACL's role in acetyl‐CoA production.
Yaping Yue, Tingting Lu, Xiaoyuan Guo, Biao Liu, Shiteng Lv, Heba A. M. Abdalla, Xuelei Lai, Ruihui Zhang, Jianpin Guo, Yu Zhao, Dao‐Xiu Zhou, Shaoli Zhou   +11 more
wiley   +1 more source

Pharmacological induction of acetyl-CoA carboxylase 1 autophagic degradation attenuates lipid accumulation and cholangiocarcinoma progression

Journal of Experimental & Clinical Cancer Research
Background Aberrant glycogen metabolism drives lipid accumulation and adaptive lipid homeostasis reprogramming, a metabolic adaptation critical for sustaining malignant progression and chemoresistance in cholangiocarcinoma (CCA).
Yani Pan, Nannan Zhang, Xueni Fu, Xinyu Wang, Yichun Ma, Qi Chen, Yue Zhou, Hongwen Liu, Yun Zhu, Lei Xu, Qiang Wang, Dongyin Chen, Zhangding Wang, Lei Wang   +13 more
doaj   +1 more source

DNMT2‐m5C‐ACLY Axis Promotes Lenvatinib Resistance in Hepatocellular Carcinoma Through Histone Acetylation‐Mediated Notch Pathway

Advanced Science, EarlyView.
Lenvatinib resistance poses a major challenge in advanced hepatocellular carcinoma (HCC). This study reveals that DNMT2 upregulation is a key driver, which stabilizes ACLY mRNA via m5C modification and activates the Notch signaling pathway. Crucially, combining ACLY inhibitors with lenvatinib overcomes resistance and suppresses tumors, offering a ...
Shiguang Yang, Jie Li, Shengwei Mao, Xuhui Zhao, Douwaner Liu, Jiafeng Chen, Jialu Fu, Yichao Bu, Xiaoling Wu, Shaoqing Liu, Qifeng Yu, Qiongzhu Dong, Zheng Tang, Yuan Fang, Yinghong Shi   +14 more
wiley   +1 more source

Mechanisms of Direct Electron Transfer Governed by Redox‐Active Conductive Carrier with Superior Wettability in Anaerobic Biofilms

Advanced Science, EarlyView.
A redox‐active conductive carrier of tannic acid‐modified iron‐biochar with superior wettability is demonstrated to regulate direct electron transfer at the anaerobic biofilm‐carrier interface by enhancing the cytochrome c‐mediated pathway. For the first time, integrated evidence from spectroscopy, electrochemical analyses, and metatranscriptomics ...
Junli Tian, Xiaoyuan Zhang, Lulu Xing, Bin Ji, Jinfeng Lu, Yu Liu   +5 more
wiley   +1 more source

Rescuing Mitochondrial Dysfunction in Macrophages Prevents Osteonecrosis of the Jaw in Anti‐Resorptive Therapy

Advanced Science, EarlyView.
Schematic model showing the suggested mechanism that ZA induces classical activation of macrophages by impairing mitochondrial biofunction and inhibiting mitochondrial clearance to contribute to the pathological process of BRONJ. RAPA‐loaded nanoparticles ZDPR has shown potential in alleviating BRONJ lesions as well as treating osteoporosis or ...
Hang Zhang, Xin Shen, Haiyang Liu, Xinxi Yuan, Mumin Cao, Xuepeng Lv, Ziji Ling, Songsong Guo, Rongyao Xu, Xiang Li, Hongbing Jiang   +10 more
wiley   +1 more source