Results 61 to 70 of about 2,632,092 (318)

Acetyl‐coenzyme A carboxylase alpha promotion of glucose‐mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients

Hepatology, 2016
Solid tumors often suffer from suboptimal oxygen and nutrient supplies. This stress underlies the requirement for metabolic adaptation. Aberrantly activated de novo lipogenesis is critical for development and progression of human hepatocellular carcinoma
Ming-Da Wang, Han Wu, Gongbo Fu, Hui‐Lu Zhang, Xu Zhou, Liang Tang, Liwei Dong, Chen-Jie Qin, Shuai Huang, Ling-hao Zhao, Min Zeng, Mengchao Wu, Hexin Yan, Hong-Yang Wang   +13 more
semanticscholar   +1 more source

Exploring the Role of ATP-Citrate Lyase in the Immune System

Frontiers in Immunology, 2021
Studies over the past decade have revealed that metabolism profoundly influences immune responses. In particular, metabolism causes epigenetic regulation of gene expression, as a growing number of metabolic intermediates are substrates for histone post ...
Monica Dominguez, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Dmitry Namgaladze   +5 more
doaj   +1 more source

Unstructured regions of large enzymatic complexes control the availability of metabolites with signaling functions

Cell Communication and Signaling, 2020
Metabolites produced via traditional biochemical processes affect intracellular communication, inflammation, and malignancy. Unexpectedly, acetyl-CoA, α-ketoglutarate and palmitic acid, which are chemical species of reactions catalyzed by highly abundant,
Ioannis Skalidis, Christian Tüting, Panagiotis L. Kastritis   +2 more
doaj   +1 more source

Acetyl-CoA synthetase 2(ACSS2): a review with a focus on metabolism and tumor development

Discover Oncology, 2022
Acetyl-CoA synthetase 2 (ACSS2), an important member of the acetyl-CoA synthetase (ACSS) family, can catalyze the conversion of acetate to acetyl coenzyme A (acetyl-CoA).
Rui Ling, Gong Chen, Xiang Tang, Na Liu, Yuepeng Zhou, Deyu Chen   +5 more
doaj   +1 more source

Activation of immobilized acetyl-Coenzyme A carboxylase [PDF]

Biochemical Journal, 1978
Partially purified acetyl-CoA carboxylase was covalently bound to a Sepharose 4B matrix. Although aggregation was thus prevented, the enzymic activity was stimulated by citrate and isocitrate.
J Lampert, A D Landman
openaire   +3 more sources

Acetylation-mediated remodeling of the nucleolus regulates cellular acetyl-CoA responses.

PLoS Biology, 2020
The metabolite acetyl-coenzyme A (acetyl-CoA) serves as an essential element for a wide range of cellular functions including adenosine triphosphate (ATP) production, lipid synthesis, and protein acetylation.
Ryan Houston, Shiori Sekine, Michael J Calderon, Fayaz Seifuddin, Guanghui Wang, Hiroyuki Kawagishi, Daniela A Malide, Yuesheng Li, Marjan Gucek, Mehdi Pirooznia, Alissa J Nelson, Matthew P Stokes, Jacob Stewart-Ornstein, Steven J Mullett, Stacy G Wendell, Simon C Watkins, Toren Finkel, Yusuke Sekine   +17 more
doaj   +1 more source

Coenzyme A activation of acetyl-CoA carboxylase.

Journal of Biological Chemistry, 1981
Acetyl-CoA carboxylase is activated by physiological concentrations of CoA. Activation of partially purified enzyme by CoA is accompanied by a decrease in the Km for acetyl-CoA from 0.2 mM to about 4 microM, which is the physiological concentration of acetyl-CoA in the cytosol.
Li-An Yeh, Chung S. Song, K.H. Kim
openalex   +3 more sources

Construction of an artificial phosphoketolase pathway that efficiently catabolizes multiple carbon sources to acetyl-CoA.

PLoS Biology, 2023
The canonical glycolysis pathway is responsible for converting glucose into 2 molecules of acetyl-coenzyme A (acetyl-CoA) through a cascade of 11 biochemical reactions.
Yiqun Yang, Yuwan Liu, Haodong Zhao, Dingyu Liu, Jie Zhang, Jian Cheng, Qiaoyu Yang, Huanyu Chu, Xiaoyun Lu, Mengting Luo, Xiang Sheng, Yi-Heng P J Zhang, Huifeng Jiang, Yanhe Ma   +13 more
doaj   +1 more source

Respiratory complex I‐mediated NAD+ regeneration regulates cancer cell proliferation through the transcriptional and translational control of p21Cip1 expression by SIRT3 and SIRT7

Molecular Oncology, EarlyView.
NAD+ regeneration by mitochondrial complex I NADH dehydrogenase is important for cancer cell proliferation. Specifically, NAD+ is necessary for the activities of NAD+‐dependent deacetylases SIRT3 and SIRT7, which suppress the expression of p21Cip1 cyclin‐dependent kinase inhibitor, an antiproliferative molecule, at the translational and transcriptional
Masato Higurashi, Kazunori Mori, Hidetsugu Nakagawa, Momoko Uchida, Fumihiro Ishikawa, Motoko Shibanuma   +5 more
wiley   +1 more source

Dissecting the Hydrolytic Activities of Sarcoplasmic Reticulum ATPase in the Presence of Acetyl Phosphate [PDF]

J Biol Chem . 2002 Oct 11;277(41):38127-32
Sarcoplasmic reticulum vesicles and purified Ca$^{2+}$-ATPase hydrolyze acetyl phosphate both in the presence and absence of Ca$^{2+}$. The Ca$^{2+}$-independent activity was fully sensitive to vanadate, insensitive to thapsigargin, and proceeded without accumulation of phosphorylated enzyme.
arxiv   +1 more source