Results 81 to 90 of about 9,200 (244)

Metabolomics analysis of children with autism, idiopathic-developmental delays, and Down syndrome. [PDF]

, 2019
Although developmental delays affect learning, language, and behavior, some evidence suggests the presence of disturbances in metabolism are associated with psychiatric disorders.
Abbeduto, Leonard, Hertz-Picciotto, Irva, Orozco, Jennie Sotelo, Slupsky, Carolyn M   +3 more
core   +1 more source

Maximal Oxidative Capacity during Exercise Is Associated with Skeletal Muscle Fuel Selection and Dynamic Changes in Mitochondrial Protein Acetylation [PDF]

, 1995
SummaryMaximal exercise-associated oxidative capacity is strongly correlated with health and longevity in humans. Rats selectively bred for high running capacity (HCR) have improved metabolic health and are longer-lived than their low-capacity ...
Overmyer, Katherine A., Evans, Charles R., Qi, Nathan R., Minogue, Catherine E., Carson, Joshua J., Chermside-Scabbo, Christopher J., Koch, Lauren G., Britton, Steven L., Pagliarini, David J., Coon, Joshua J., Burant, Charles F.   +10 more
core   +1 more source

OCTN2 Activates a Non‐Canonical Carnitine Metabolic Pathway to Promote MASH‐HCC Progression and Immunotherapy Resistance

Advanced Science, Volume 13, Issue 16, 18 March 2026.
In non‐MASH‐HCC, L‐carnitine promotes tumor progression primarily through its classical role in enhancing fatty acid oxidation (FAO). However, in MASH‐HCC, where FAO is markedly suppressed, L‐carnitine shifts from this canonical function to serve instead as an intracellular acetyl group buffer.
Chuqi Xia, Xiao Zhang, Jinze Li, Ning Xu, Sheng Hu, Qiyu Lu, Yuxuan Li, Taifu Xiao, Xu Li, Xue Wang, Kequan Xu, Daoming Liang   +11 more
wiley   +1 more source

Randomized Clinical Trial for the Optimization of Dyslipidemia Management in Patients with End-Stage Renal Disease Undergoing In-Hospital Maintenance Hemodialysis Therapy

Pharmaceutics
Background/Objectives: End-stage renal disease (ESRD) patients on maintenance hemodialysis (MHD) frequently develop L-carnitine (LC) deficiency, leading to dyslipidemia and increased cardiovascular risk. While LC supplementation may improve dyslipidemia,
Sadia Rehman, Muhammad Farhan, Muhammad Raza Sarfraz, Asma Naveed, Fahad Usman, Anila Bibi, Raheel Ahmed, Hiya Huq, Ali Hasan, Jarin Anzoom, Pobitro Kumar   +10 more
doaj   +1 more source

Cerebellar mitochondrial dysfunction and concomitant multi-system fatty acid oxidation defects are sufficient to discriminate PTSD-like and resilient male mice

Brain, Behavior, & Immunity - Health, 2020
The impact of trauma on mental health is complex with poorly understood underlying mechanisms. Mitochondrial dysfunction is increasingly implicated in psychopathologies and mood disorders, including post-traumatic stress disorder (PTSD).
Graeme Preston, Tim Emmerzaal, Faisal Kirdar, Laura Schrader, Marloes Henckens, Eva Morava, Tamas Kozicz   +6 more
doaj   +1 more source

Carnitine and/or Acetylcarnitine Deficiency as a Cause of Higher Levels of Ammonia

BioMed Research International, 2016
Blood carnitine and/or acetylcarnitine deficiencies are postulated in the literature as possible causes of higher ammonia levels. The aim of this study was to investigate if the use of valproic acid, the age of the patients, or certain central nervous ...
Cecilia Maldonado, Natalia Guevara, C. Queijo, R. González, P. Fagiolino, M. Vázquez   +5 more
semanticscholar   +1 more source

Maintenance of Carnitine Homeostasis as a Therapeutic Strategy to Attenuate Cisplatin‐Induced Acute Kidney Injury

Food Frontiers, Volume 7, Issue 2, March 2026.
ABSTRACT Acute kidney injury (AKI) has emerged as a significant global public health concern due to its high morbidity and mortality rates. Cisplatin, a highly effective and widely used chemotherapeutic agent, is often limited in clinical application by its nephrotoxicity, particularly AKI.
Mingkang Zhang, Yazhi Wang, Xiujuan Wang, Yan Zhou, Yanrong Ma, Xin'an Wu   +5 more
wiley   +1 more source

Metabolic Inertia in Contracting Skeletal Muscle: The Expanding Role of the Carnitine Pool [PDF]

, 2018
Summary.: The ability of the muscular carnitine pool to accept and temporally donate acetyl groups (from and towards the coenzyme A pool) is an important functional role of carnitine within biological systems that is often overlooked within the ...
Roberts, Paul A.
core  

Monitoring cancer prognosis, diagnosis and treatment efficacy using metabolomics and lipidomics [PDF]

, 2016
Introduction: Cellular metabolism is altered during cancer initiation and progression, which allows cancer cells to increase anabolic synthesis, avoid apoptosis and adapt to low nutrient and oxygen availability.
Armitage, Emily G., Southam, Andrew D.
core   +2 more sources

Retention of acetylcarnitine in chronic kidney disease causes insulin resistance in skeletal muscle

Journal of clinical biochemistry and nutrition, 2016
Insulin resistance occurs frequently in patients with chronic kidney disease. However, the mechanisms of insulin resistance associated with chronic kidney disease are unclear. It is known that an increase in the mitochondrial acetyl-CoA (AcCoA)/CoA ratio
Y. Miyamoto, T. Miyazaki, A. Honda, H. Shimohata, K. Hirayama, Masaki Kobayashi   +5 more
semanticscholar   +1 more source