Results 11 to 20 of about 38,821 (204)
Acid-Sensing Ion Channels in Zebrafish [PDF]
Animals, 2021 The ASICs, in mammals as in fish, control deviations from the physiological values of extracellular pH, and are involved in mechanoreception, nociception, or taste receptions. They are widely expressed in the central and peripheral nervous system.
Giuseppe Montalbano +7 more
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Acid-Sensing Ion Channels in Glial Cells [PDF]
Membranes, 2022 Acid-sensing ion channels (ASICs) are proton-gated cation channels and key mediators of responses to neuronal injury. ASICs exhibit unique patterns of distribution in the brain, with high expression in neurons and low expression in glial cells.
Victoria Cegielski +5 more
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The role of acid sensing ion channels in the cardiovascular function [PDF]
Frontiers in Physiology, 2023 Acid Sensing Ion Channels (ASIC) are proton sensors involved in several physiological and pathophysiological functions including synaptic plasticity, sensory systems and nociception.
Omar López-Ramírez +1 more
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Zinc Permeation Through Acid-Sensing Ion Channels [PDF]
CellsAcid-sensing ion channels (ASICs), activated under acidic conditions, play a critical role in ischemic brain injury, but the detailed mechanisms and signaling pathways remain unclear.
Xiang-Ping Chu +2 more
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Neurodegenerative Disease: What Potential Therapeutic Role of Acid-Sensing Ion Channels? [PDF]
Frontiers in Cellular Neuroscience, 2021 Acidic pH shift occurs in many physiological neuronal activities such as synaptic transmission and synaptic plasticity but also represents a characteristic feature of many pathological conditions including inflammation and ischemia.
Dalila Mango +3 more
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Tumor Biology, 2017 Acid-sensing ion channels, a proton-gated cation channel, can be activated by low extracellular pH and involved in pathogenesis of some tumors such as glioma and breast cancer.
Yu Wu +5 more
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Peripheral and central employment of acid-sensing ion channels during early bilaterian evolution [PDF]
eLife, 2023 Nervous systems are endowed with rapid chemosensation and intercellular signaling by ligand-gated ion channels (LGICs). While a complex, bilaterally symmetrical nervous system is a major innovation of bilaterian animals, the employment of specific LGICs ...
Josep Martí-Solans +4 more
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The His-Gly motif of acid-sensing ion channels resides in a reentrant ‘loop’ implicated in gating and ion selectivity [PDF]
eLife, 2020 Acid-sensing ion channels (ASICs) are proton-gated members of the epithelial sodium channel/degenerin (ENaC/DEG) superfamily of ion channels and are expressed throughout the central and peripheral nervous systems.
Nate Yoder, Eric Gouaux
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Basics on the use of acid-sensing ion channels’ inhibitors as therapeutics
Neural Regeneration Research, 2019 Since the discovery of acid-sensing ion channels in 1997, their importance in the health of neurons and other non-neuronal cells has gained significant importance. Acid-sensing ion channels play important roles in mediating pain sensation during diseases
Jamileh Dibas +2 more
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Hydrogen Sulfide, an Emerging Regulator of Acid-Sensing Ion Channels [PDF]
Function, 2021 Csaba Szabo
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