Results 21 to 30 of about 38,821 (204)

Acid-Sensing Ion Channels and Mechanosensation. [PDF]

Int J Mol Sci, 2021
Ruan N, Tribble J, Peterson AM, Jiang Q, Wang JQ, Chu XP.   +5 more
europepmc   +2 more sources

Acid-Sensing Ion Channels: Focus on Physiological and Some Pathological Roles in the Brain. [PDF]

Curr Neuropharmacol, 2021
Storozhuk M, Cherninskyi A, Maximyuk O, Isaev D, Krishtal O.   +4 more
europepmc   +2 more sources

Coupling structure with function in acid-sensing ion channels: challenges in pursuit of proton sensors. [PDF]

J Physiol, 2021
Rook ML, Musgaard M, MacLean DM.
europepmc   +2 more sources

Acid-sensing ion channels in sensory signaling.

Am J Physiol Renal Physiol, 2020
Carattino MD, Montalbetti N.
europepmc   +2 more sources

Gating mechanisms of acid-sensing ion channels. [PDF]

Nature, 2018
Yoder N, Yoshioka C, Gouaux E.
europepmc   +2 more sources

Peripheral Inflammation Results in Increased Excitability of Capsaicin-Insensitive Nociceptive DRG Neurons Mediated by Upregulation of ASICs and Voltage-Gated Ion Channels

Frontiers in Cellular Neuroscience, 2021
Previously, we have characterized the capsaicin-insensitive low pH-sensitive (caps−lpH+) subtype of small-sized nociceptive dorsal root ganglion (DRG) neurons that express acid-sensing ion channels, T-type Ca2+ channels, and have isolectin B4-negative ...
Dmytro E. Duzhyy, Nana V. Voitenko, Nana V. Voitenko, Nana V. Voitenko, Pavel V. Belan, Pavel V. Belan   +5 more
doaj   +1 more source

Ion Channel Genes in Painful Neuropathies

Biomedicines, 2023
Neuropathic pain (NP) is a typical symptom of peripheral nerve disorders, including painful neuropathy. The biological mechanisms that control ion channels are important for many cell activities and are also therapeutic targets.
Milena Ślęczkowska, Kaalindi Misra, Silvia Santoro, Monique M. Gerrits, Janneke G. J. Hoeijmakers   +4 more
doaj   +1 more source

Molecular Basis for Mambalgin-2 Interaction with Heterotrimeric α-ENaC/ASIC1a/γ-ENaC Channels in Cancer Cells

Toxins, 2023
Cancer progression is characterized by microenvironmental acidification. Tumor cells adapt to low environmental pH by activating acid-sensing trimeric ion channels of the DEG/ENaC family.
Ekaterina N. Lyukmanova, Maxim M. Zaigraev, Dmitrii S. Kulbatskii, Aizek B. Isaev, Ilya D. Kukushkin, Maxim L. Bychkov, Mikhail A. Shulepko, Anton O. Chugunov, Mikhail P. Kirpichnikov   +8 more
doaj   +1 more source

Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]

PLoS ONE, 2013
It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
doaj   +1 more source

Functional modifications of acid-sensing ion channels by ligand-gated chloride channels. [PDF]

PLoS ONE, 2011
Together, acid-sensing ion channels (ASICs) and epithelial sodium channels (ENaC) constitute the majority of voltage-independent sodium channels in mammals. ENaC is regulated by a chloride channel, the cystic fibrosis transmembrane conductance regulator (
Xuanmao Chen, Paul Whissell, Beverley A Orser, John F MacDonald   +3 more
doaj   +1 more source