Results 31 to 40 of about 38,821 (204)

Ketone Bodies Inhibit the Opening of Acid-Sensing Ion Channels (ASICs) in Rat Hippocampal Excitatory Neurons in vitro

Frontiers in Neurology, 2019
Objectives: Despite the long-term efficacy of antiepileptic drug treatments, frequent attacks of drug-resistant epilepsy necessitate the development of new antiepileptic drug therapy targets.
Fei Zhu, Fei Zhu, Fei Zhu, Fei Zhu, Wei Shan, Wei Shan, Wei Shan, Wei Shan, Qinlan Xu, Qinlan Xu, Qinlan Xu, Anchen Guo, Anchen Guo, Jianping Wu, Jianping Wu, Jianping Wu, Qun Wang, Qun Wang, Qun Wang   +18 more
doaj   +1 more source

Acid-Sensing Ion Channels and Pain

Pharmaceuticals, 2010
Pathophysiological conditions such as inflammation, ischemia, infection and tissue injury can all evoke pain, and each is accompanied by local acidosis.
Qihai Gu, Lu-Yuan Lee
doaj   +1 more source

Plant-derived natural products targeting ion channels for pain

Neurobiology of Pain, 2023
Chronic pain affects approximately one-fifth of people worldwide and reduces quality of life and in some cases, working ability. Ion channels expressed along nociceptive pathways affect neuronal excitability and as a result modulate pain experience ...
Sachin Goyal, Shivali Goyal, Aleyah E. Goins, Sascha R.A. Alles   +3 more
doaj   +1 more source

The ASIC3-M-CSF-M2 macrophage-positive feedback loop modulates fibroblast-to-myofibroblast differentiation in skin fibrosis pathogenesis

Cell Death and Disease, 2022
Inflammation is one of the main pathological features leading to skin fibrosis and a key factor leading to the progression of skin fibrosis. Acidosis caused by a decrease in extracellular pH is a sign of the inflammatory process.
Jun-Jie Wu, Zi-Li Sun, Si-Yu Liu, Zhong-Hua Chen, Zheng-Dong Yuan, Ming-Li Zou, Ying-Ying Teng, Yue-Yue Li, Dan-Yang Guo, Feng-Lai Yuan   +9 more
doaj   +1 more source

Acid-sensing ion channels: trafficking and synaptic function

Molecular Brain, 2013
Extracellular acidification occurs in the brain with elevated neural activity, increased metabolism, and neuronal injury. This reduction in pH can have profound effects on brain function because pH regulates essentially every single biochemical reaction.
Zha Xiang-ming
doaj   +1 more source

Regulation of pain neurotransmitters and chondrocytes metabolism mediated by voltage-gated ion channels: A narrative review

Heliyon, 2023
Osteoarthritis (OA) is one of the leading causes of chronic pain and dysfunction. It is essential to comprehend the nature of pain and cartilage degeneration and its influencing factors on OA treatment. Voltage-gated ion channels (VGICs) are essential in
Xinwei Wang, Xueping Li
doaj   +1 more source

Pancreatic ductal bicarbonate secretion: challenge of the acinar acid load

Frontiers in Physiology, 2011
Acinar and ductal cells of the exocrine pancreas form a close functional unit. Although most studies contain data either on acinar or ductal cells, an increasing number of evidence highlights the importance of the pancreatic acinar-ductal functional unit.
Peter eHegyi, Jozsef eMaléth, Viktória eVenglovecz, Zoltan eRakonczay   +3 more
doaj   +1 more source

A Tale of Toxin Promiscuity: The Versatile Pharmacological Effects of Hcr 1b-2 Sea Anemone Peptide on Voltage-Gated Ion Channels

Marine Drugs, 2022
Sea anemones are a rich source of biologically active compounds. Among approximately 1100 species described so far, Heteractis crispa species, also known as sebae anemone, is native to the Indo-Pacific area.
Ernesto Lopes Pinheiro-Junior, Rimma Kalina, Irina Gladkikh, Elena Leychenko, Jan Tytgat, Steve Peigneur   +5 more
doaj   +1 more source

Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing

Journal of Biomedical Science, 2018
Background Acid-sensing ion channels (ASICs) are a group of amiloride-sensitive ligand-gated ion channels belonging to the family of degenerin/epithelial sodium channels. ASICs are predominantly expressed in both the peripheral and central nervous system
Yuan-Ren Cheng, Bo-Yang Jiang, Chih-Cheng Chen   +2 more
doaj   +1 more source

OPINION: History and Perspectives of ASICs

BBA Advances, 2023
The author recalls several particularly memorable events during his scientific career that led to the discovery of acid-sensing ion channels and ionotropic purinergic receptors.
Oleg Krishtal
doaj   +1 more source