Results 131 to 140 of about 3,455 (202)

A multi-dimensional view of context-dependent G protein-coupled receptor function. [PDF]

, 2023
G protein-coupled receptor (GPCR) family members can sense an extraordinary variety of biomolecules to activate intracellular signalling cascades that modulate key aspects of cell physiology. Apart from their crucial role in maintaining cell homeostasis,

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Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

Frontiers in Immunology, 2018
CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response ...
Rik Janssens, Rik Janssens, Daiane Boff, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flávio A. Amaral, Paul Proost   +19 more
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Role of Atypical Chemokine Receptors in Microglial Activation and Polarization. [PDF]

, 2017
Inflammatory reactions occurring in the central nervous system (CNS), known as neuroinflammation, are key components of the pathogenic mechanisms underlying several neurological diseases.
Del Prete, A., Salvi, V, Sozio, F, Sozzani, S   +3 more
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ACKR3 in Health and Disease

Introduced in Chapter 1, Cxcl12 and Cxcr4 play crucial roles during development, adult life and pathophysiology, in particular in hematopoiesis, inflammatory disease and cancer progression. Hematopoiesis relies on a complex interplay between hematopoietic cells and supporting stromal cells within specialized bone marrow (BM) niches.
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Identification of whole blood mRNA and microRNA biomarkers of tissue damage and immune function resulting from amphetamine exposure or heat stroke in adult male rats.

PLoS ONE, 2019
This work extends the understanding of how toxic exposures to amphetamine (AMPH) adversely affect the immune system and lead to tissue damage. Importantly, it determines which effects of AMPH are and are not due to pronounced hyperthermia.
Luísa Camacho, Camila S Silva, Joseph P Hanig, Robert P Schleimer, Nysia I George, John F Bowyer   +5 more
doaj   +1 more source

The Role of C-X-C motif chemokine 12 in the crosstalk of brown adipocytes and microvascular endothelial cells [PDF]

The pandemic of obesity keeps on rising. Especially from a pharmacological point of view, treatment options are quite limited. Late research has shown that brown adipose tissue might be a promising target for the development of innovative therapeutic ...
Retiet, Max
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Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
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ACKR3 Gene [PDF]

, 2020
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ACKR3 wt Allele [PDF]

, 2020
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Kinetics and Systems: Experimental and Modelling Approaches to Analyse Signalling and Trafficking Patterns of CXCR4 and ACKR3

G protein-coupled receptors (GPCRs) are a large family of cell-surface proteins involved in the transduction of a wide range of signals to initiate appropriate cellular response.
Pan, Kylie Shenglan
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