Results 171 to 180 of about 3,165 (181)

Structural Basis of Nanobody Induced ACKR3 Inhibition

The FASEB Journal, 2022
When bound to their small, secreted chemotactic cytokine ligands (chemokines), the G protein‐coupled receptor (GPCR) subfamily known as chemokine receptors (CKRs) can promote cell proliferation, survival, and migration towards increasing chemokine concentration gradients.
Roman Schlimgen, Francis Peterson, Raimond Heukers, Martine Smit, John McCorvy, Brian Volkman   +5 more
openaire   +1 more source

BMP2 induces osteogenic differentiation through ACKR3 in mesenchymal stem cells

Biochemical and Biophysical Research Communications, 2023
In recent years, bone loss related diseases have attracted more and more attention, such as osteoporosis and osteonecrosis of the femoral head exhibited symptoms of osteopenia or insufficient bone mass in a certain stage. Mesenchymal stem cells (MSCs), which can be induced to differentiate into osteoblasts under certain conditions can provide a new ...
Jiang, Liu, Xin-Tong, Yao, Xiao-Lei, Feng, Xi-Zhuang, Bai   +3 more
openaire   +2 more sources

ACKR3 orchestrates Hedgehog signaling to promote renal cell carcinoma progression

Molecular Carcinogenesis, 2023
AbstractRenal cell carcinoma (RCC) is the second commonest urological malignant neoplasm and mortality rate of patients with RCC appears to be increasing each year. Thus, further understanding of the molecular mechanisms responsible for the development and progression of RCC is of particular importance.
Chao, Tang, Lin, Li, Qiang, Xu, Shouying, Xu, Chao, Lin, Bin, Cao   +5 more
openaire   +2 more sources

Lymphatic activation of ACKR3 signaling regulates lymphatic response after ischemic heart injury

Arteriosclerosis, Thrombosis, and Vascular Biology
2.AbstractBackgroundIschemic heart disease is a prevalent cause of death and disability worldwide. Recent studies reported a rapid expansion of the cardiac lymphatic network upon ischemic heart injury and proposed that cardiac lymphatics may attenuate tissue edema and inflammatory mechanisms after ischemic heart injury.
Laszlo Balint, Shubhangi Patel, Donald Stephen Serafin, Hua Zhang, Kelsey E. Quinn, Amir Aghajanian, Bryan M. Kistner, Kathleen M. Caron   +7 more
openaire   +3 more sources

ACKR3 is differentially expressed in glioblastoma.

Glioblastoma is difficult to treat and patients are often provided poor prognosis (1), indicating a requirement for therapeutic target identification and drug development. Differentially expressed genes represent by definition among the most promising targets for the development of novel chemotherapies (2, 3).
openaire   +1 more source

Étude des mécanismes d'action du récepteur de chimiokine CXCR7/ACKR3

2018
Le récepteur de chimiokine CXCR7 découvert récemment a été identifié comme liant la chimiokine CXCL12, qui était, jusqu’à ce jour, considérée comme ligand exclusif du récepteur de chimiokine CXCR4 (Balabanian et al., 2005). Ces deux récepteurs se trouvent exprimés au sein des mêmes types cellulaires.
openaire   +1 more source

Funktion und Regulation von ACKR3 an der Blut-Hirn-Schranke

CXCR4 vermittelt in der embryonalen Entwicklung über Gαi-Signalwege die Zellmigration, während ACKR3 als Scavengerrezeptor den CXCL12-Gradienten aufrechterhält. Auch in adulten Organismen transduziert CXCR4 chemotaktische Signale. So ist der Rezeptor an der Retention von HSZ im Knochenmark beteiligt und reguliert die Migration von Leukozyten über die ...
openaire   +1 more source

Faculty Opinions recommendation of ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature, 2019
openaire   +1 more source

ACKR3

2015
openaire   +1 more source

Dysregulation of ACKR3 expression in Parkinson's Disease.

openaire   +1 more source