Results 181 to 190 of about 3,455 (202)

Structural Basis of Nanobody Induced ACKR3 Inhibition

The FASEB Journal, 2022
When bound to their small, secreted chemotactic cytokine ligands (chemokines), the G protein‐coupled receptor (GPCR) subfamily known as chemokine receptors (CKRs) can promote cell proliferation, survival, and migration towards increasing chemokine concentration gradients.
Roman Schlimgen, Francis Peterson, Raimond Heukers, Martine Smit, John McCorvy, Brian Volkman   +5 more
openaire   +1 more source

MIF–ACKR3 Signaling Drives Cancer Cachexia by Impairing Adipogenesis

Cancer Discovery

semanticscholar   +2 more sources

CXCL12/ACKR3 chemokine axis: a molecular regulator of aortic valve homeostasis and pathology

European Heart Journal
Calcific aortic valve disease (CAVD), the most prevalent valvular heart disease, remains an irreversible and progressive disorder characterized by fibrocalcific remodeling of the aortic valve.
V Jeyakumar, M Messner, P Schoenherr, S Staggl, C Puelacher, M Ungericht, A Logtenberg, G Poelzl, A Bauer, M M Zaruba   +9 more
semanticscholar   +1 more source

Down regulation of estrogen receptors (ER a ; ER β ) and atypical chemokine receptors (ACKR 2; ACKR3; ACKR4) to increase 17β-estradiol (E2) levels in MCF-7 in-vitro study

Basic & Clinical Cancer Research
Background: Oestrogen plays a vital role in breast development and is strongly re- lated to breast cancer. This research article delves into this paradox.
Shruti Talashi
semanticscholar   +1 more source

Role of Cx43 and ACKR3 in Modulating Astrocytic Response and Neuronal Survival Post‐Subarachnoid Hemorrhage

Glia
Subarachnoid hemorrhage (SAH) is a devastating neurological disorder that results from the accumulation of blood in the brain's subarachnoid space, leading to significant challenges in neurological recovery. This study explores the molecular interactions
Jian Yan, Shenhao Xie, Dianda Chen, Jinlin Xiao, Erming Zeng, Tao Hong, Jian Duan   +6 more
semanticscholar   +1 more source

ACKR3 is differentially expressed in glioblastoma.

Glioblastoma is difficult to treat and patients are often provided poor prognosis (1), indicating a requirement for therapeutic target identification and drug development. Differentially expressed genes represent by definition among the most promising targets for the development of novel chemotherapies (2, 3).
openaire   +1 more source

Étude des mécanismes d'action du récepteur de chimiokine CXCR7/ACKR3

2018
Le récepteur de chimiokine CXCR7 découvert récemment a été identifié comme liant la chimiokine CXCL12, qui était, jusqu’à ce jour, considérée comme ligand exclusif du récepteur de chimiokine CXCR4 (Balabanian et al., 2005). Ces deux récepteurs se trouvent exprimés au sein des mêmes types cellulaires.
openaire   +1 more source

Funktion und Regulation von ACKR3 an der Blut-Hirn-Schranke

CXCR4 vermittelt in der embryonalen Entwicklung über Gαi-Signalwege die Zellmigration, während ACKR3 als Scavengerrezeptor den CXCL12-Gradienten aufrechterhält. Auch in adulten Organismen transduziert CXCR4 chemotaktische Signale. So ist der Rezeptor an der Retention von HSZ im Knochenmark beteiligt und reguliert die Migration von Leukozyten über die ...
openaire   +1 more source

Noncanonical Regulation of ACKR3/CXCR7 on Lipid Mediators in Immunothrombotic Platelet Response following FcγRIIa Stimulation

Hämostaseologie
J. Zlamal, X. Fu, M. Laemmerhofer, K. Althaus, T. Bakchoul, M. Chatterjee   +5 more
semanticscholar   +1 more source

Binding and ubiquitination-mediated degradation of ACKR3 by the novel Scutellarein derivative TBS6b potently suppresses hepatocellular carcinoma.

Bioorganic chemistry (Print)
Xing Jiang, Ying Liang, Guotao Tang, Haiyan Quan, Lijun Ruan, Mengli Zhang, Zhijun Song, Min Ou, Zhien Tan, Na Lu, Fangfang Wu, Xiaonan Yang   +11 more
semanticscholar   +1 more source