Results 21 to 30 of about 40,002 (209)

c‐Rel–dependent Chk2 signaling regulates the DNA damage response limiting hepatocarcinogenesis

Hepatology, EarlyView., 2022
In response to genotoxic injury, c‐Rel upregulates ATM‐Chk2‐p53 pathway DNA damage proteins to limiting hepatocarcinogenesis. Abstract Background and Aims Hepatocellular carcinoma (HCC) is a leading cause of cancer‐related death. The NF‐κB transcription factor family subunit c‐Rel is typically protumorigenic; however, it has recently been reported as a
Jack Leslie, Jill E. Hunter, Amy Collins, Amelia Rushton, Lauren G. Russell, Erik Ramon‐Gil, Maja Laszczewska, Misti McCain, Marco Y. W. Zaki, Amber Knox, Yixin Seow, Laura Sabater, Daniel Geh, Neil D. Perkins, Helen L. Reeves, Dina Tiniakos, Derek A. Mann, Fiona Oakley   +17 more
wiley   +1 more source

Molecular Recognition Studies on Naphthyridine Derivatives

Molecules, 2010
The association constants Kb of three hosts I–III designed to have both enhanced hydrogen bonding donor strength and conformational preorganization with biotin analogues 1–5 are reported.
José Carlos Iglesias-Sánchez, Dolores Santa María, Rosa M. Claramunt, José Elguero   +3 more
doaj   +1 more source

Crystal Structure of a New 1:1 Acridine-Diclofenac Salt, Obtained with High Yield by a Mechanochemical Approach

Crystals, 2022
The liquid-assisted grinding (LAG) approach was exploited to efficiently produce a new salt cocrystal with a minimum expenditure of reagents and energy, with possible application in the pharmaceutical field.
Artur Mirocki, Eleonora Conterosito, Luca Palin, Artur Sikorski, Marco Milanesio, Mattia Lopresti   +5 more
doaj   +1 more source

Supramolecular interactions in a 1:1 co-crystal of acridine and 3-chlorothiophene-2-carboxylic acid

Acta Crystallographica Section E: Crystallographic Communications, 2016
In the title co-crystal, C5H3ClO2S·C13H9N, the components interact with each other via an O—H...N hydrogen bond. Acridine–acridine stacking, thiophene–thiophene stacking and acridine–thiophene C—H...π interactions also occur in the crystal.
Olakkandiyil Prajina, Packianathan Thomas Muthiah, Franc Perdih   +2 more
doaj   +1 more source

Photochemistry of Acridines. XIX. Photoreduction of Acridine in Mixed Solvents [PDF]

Bulletin of the Chemical Society of Japan, 1973
Abstract The photoreduction of acridine has been investigated in three kinds of mixed solvents, benzene-isopropanol, benzene-methanol and benzene-cyclohexane, all in aerated and deaerated conditions. The following general tendensies have been found for the plot Φrel  vs. mole fraction.
Mikio Hoshino, Masao Koizumi
openaire   +1 more source

Acridino-Diaza-20-Crown-6 Ethers: New Macrocyclic Hosts for Optochemical Metal Ion Sensing

Molecules, 2021
Acridino-diaza-20-crown-6 ether derivatives as new turn-on type fluorescent chemosensors with an excellent functionality and photophysical properties have been designed and synthesized for metal ion-selective optochemical sensing applications ...
Ádám Golcs, Korinna Kovács, Panna Vezse, Tünde Tóth, Péter Huszthy   +4 more
doaj   +1 more source

Opium trade and use during the Late Bronze Age: Organic residue analysis of ceramic vessels from the burials of Tel Yehud, Israel

Archaeometry, EarlyView., 2022
Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares, Eriola Jakoel, Ron Be’eri, Oded Lipschits, Ronny Neumann, Yuval Gadot   +5 more
wiley   +1 more source

The Crystal Structure and Intermolecular Interactions in Fenamic Acids–Acridine Complexes

Molecules, 2021
In order to improve pharmaceutical properties of drugs, complexes are synthesized as combinations with other chemical substances. The complexes of fenamic acid and its derivatives, such as mefenamic-, tolfenamic- and flufenamic acid, with acridine were ...
Marta S. Krawczyk, Adam Sroka, Irena Majerz   +2 more
doaj   +1 more source

Metal‐Free Active Template: A Straightforward Route to 4‐Aminopyridinium‐Based Rotaxane Molecular Shuttles

Angewandte Chemie, EarlyView.
Leigh's metal‐free active template‐based SNAr of an amine on halogenopyridiniums, in the presence of a crown ether, successfully afforded 4‐aminopyridinium‐containing rotaxanes. Further molecular machinery was carried out by deprotonation‐then‐carbamoylation of the conjugated amino moiety.
Ivaylo Stoyanov, Arie van der Lee, Frédéric Coutrot   +2 more
wiley   +2 more sources

Effects of Acridines on Morphogenesis

Nature, 1968
EARLY studies of the effects of acridines on amphibian egg development tended to show that RNA synthesis is required for neural induction1. Little could be concluded from these experiments, however, because the acridines available at that time were a complex mixture of substances of unknown mode of action. Acridines have since been found to bind to and
openaire   +3 more sources