Results 1 to 10 of about 2,093 (140)

Novel 3,9-Disubstituted Acridines with Strong Inhibition Activity against Topoisomerase I: Synthesis, Biological Evaluation and Molecular Docking Study [PDF]

Molecules, 2023
A series of novel 3,9-disubstituted acridines were synthesized and their biological potential was investigated. The synthetic plan consists of eight reaction steps, which produce the final products, derivatives 17a–17j, in a moderate yield.
Kristína Krochtová, Annamária Halečková, Ladislav Janovec, Michaela Blizniaková, Katarína Kušnírová, Mária Kožurková   +5 more
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Can Zeolite-Supporting Acridines Boost Their Anticancer Performance? [PDF]

Journal of Functional Biomaterials, 2023
Acridine and its derivatives (9-chloroacridine and 9-aminoacridine) are investigated here, supported on FAU type zeolite Y, as a delivery system of anticancer agents. FTIR/Raman spectroscopy and electron microscopy revealed successful drug loading on the
Maja Ranković, Anka Jevremović, Aleksandra Janošević Ležaić, Aleksandar Arsenijević, Jelena Rupar, Vladimir Dobričić, Bojana Nedić Vasiljević, Nemanja Gavrilov, Danica Bajuk-Bogdanović, Maja Milojević-Rakić   +9 more
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Synthesis, Stability, and Biological Evaluation of Novel Aminoderivatives Incorporating the Aza-Acridine Scaffold [PDF]

Molecules
Several new amino-substituted aza-acridine derivatives bearing one or two basic side chains have been designed and synthesized. Their anticancer activities were evaluated in vitro against two human cancer cell lines: T24 (urothelial bladder carcinoma ...
Maria Karelou, Anthi Panara, Eleftheria Chatziorfanou, Aikaterini F. Giannopoulou, Dimitrios J. Stravopodis, Evagelos Gikas, Ioannis K. Kostakis   +6 more
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Acridine as an Anti-Tumour Agent: A Critical Review [PDF]

Molecules, 2022
This review summarized the current breakthroughs in the chemistry of acridines as anti-cancer agents, including new structural and biologically active acridine attributes.
Potlapati Varakumar, Kalirajan Rajagopal, Baliwada Aparna, Kannan Raman, Gowramma Byran, Clara Mariana Gonçalves Lima, Salma Rashid, Mohammed H. Nafady, Talha Bin Emran, Sławomir Wybraniec   +9 more
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New Boron Containing Acridines: Synthesis and Preliminary Biological Study [PDF]

Molecules, 2023
The synthesis of the first conjugates of acridine with cobalt bis(dicarbollide) are reported. A novel 9-azido derivative of acridine was prepared through the reaction of 9-methoxyacridine with N3CH2CH2NH2, and its solid-state molecular structure was ...
Anna A. Druzina, Nadezhda V. Dudarova, Ivan V. Ananyev, Anastasia A. Antonets, Dmitry N. Kaluzhny, Alexey A. Nazarov, Igor B. Sivaev, Vladimir I. Bregadze   +7 more
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Derivatives of 9-phosphorylated acridine as butyrylcholinesterase inhibitors with antioxidant activity and the ability to inhibit β-amyloid self-aggregation: potential therapeutic agents for Alzheimer’s disease [PDF]

Frontiers in Pharmacology, 2023
We investigated the inhibitory activities of novel 9-phosphoryl-9,10-dihydroacridines and 9-phosphorylacridines against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and carboxylesterase (CES).
Galina F. Makhaeva, Nadezhda V. Kovaleva, Elena V. Rudakova, Natalia P. Boltneva, Sofya V. Lushchekina, Sofya V. Lushchekina, Tatiana Yu Astakhova, Elena N. Timokhina, Olga G. Serebryakova, Alexander V. Shchepochkin, Alexander V. Shchepochkin, Maxim A. Averkov, Maxim A. Averkov, Irina A. Utepova, Irina A. Utepova, Nadezhda S. Demina, Eugene V. Radchenko, Eugene V. Radchenko, Vladimir A. Palyulin, Vladimir A. Palyulin, Vladimir P. Fisenko, Sergey O. Bachurin, Oleg N. Chupakhin, Oleg N. Chupakhin, Valery N. Charushin, Valery N. Charushin, Rudy J. Richardson, Rudy J. Richardson, Rudy J. Richardson, Rudy J. Richardson   +29 more
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Synthesis of N-acyl carbazoles, phenoxazines and acridines from cyclic diaryliodonium salts [PDF]

Beilstein Journal of Organic Chemistry
N-Acyl carbazoles can be efficiently produced through a single-step process using amides and cyclic diaryliodonium triflates. This convenient reaction is facilitated by copper iodide in p-xylene, using the commonly found activating ligand diglyme.
Nils Clamor, Mattis Damrath, Thomas J. Kuczmera, Daniel Duvinage, Boris J. Nachtsheim   +4 more
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In Silico and In Vitro Investigation of Cytotoxicity and Apoptosis of Acridine/Sulfonamide Hybrids Targeting Topoisomerases I and II [PDF]

Pharmaceuticals
Background: Sulfonamide acridine derivatives have garnered significant attention from medicinal chemists due to their diverse range of biological activities. Methods: In this study, eleven compounds were synthesized according to the literature, and their
Mohamed Badr, Elshaymaa I. Elmongy, Doaa Elkhateeb, Yasmine S. Moemen, Ashraf Khalil, Hadeer Ali, Reem Binsuwaidan, Feby Awadallah, Ibrahim El Tantawy El Sayed   +8 more
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Structure and stability of human telomeric G-quadruplex with preclinical 9-amino acridines. [PDF]

PLoS ONE, 2013
G-quadruplexes are higher-order DNA structures formed from guanine-rich sequences, and have been identified as attractive anticancer drug targets.
Ruben Ferreira, Roberto Artali, Adam Benoit, Raimundo Gargallo, Ramon Eritja, David M Ferguson, Yuk Y Sham, Stefania Mazzini   +7 more
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New 9-aminoacridine derivatives as inhibitors of Botulinum neurotoxins and P. falciparum malaria [PDF]

Journal of the Serbian Chemical Society, 2013
Steroidal and adamantane aminoacridine derivatives were prepared and tested as both botulinum neurotoxin (BoNT) inhibitors and antimalarials. Steroid-bound acridines provided good potency against both the BoNT/A and BoNT/B light chains (LCs ...
Tot Mikloš, Opsenica Dejan M., Mitrić Milena, Burnett James C., Gomba Laura, Bavari Sina, Šolaja Bogdan A.   +6 more
doaj   +1 more source