Results 101 to 110 of about 28,434 (232)
Engineering, 2015 The emergence of multidrug-resistant bacteria creates an urgent need for alternative antibiotics with new mechanisms of action. In this study, we synthesized a novel type of antimicrobial agent, Acr3-NLS, by conjugating hydrophobic acridines to the N ...
Wei Zhang +7 more
doaj +1 more source
Mechanisms of Small Molecule-DNA Interactions Probed by Single-molecule Force Spectroscopy [PDF]
, 2016 There is a wide range of applications for non-covalent DNA binding ligands, and optimization of such interactions requires detailed understanding of the binding mechanisms.
Almaqwashi, Ali A. +3 more
core +3 more sources
Boron‐10 carriers and their applications in boron neutron capture therapy
Precision Radiation Oncology, EarlyView.Summary of different types of boron drugs. Abstract Boron neutron capture therapy (BNCT) has emerged as a promising therapeutic modality in cancer treatment, demonstrating the ability to selectively eliminate cancer cells through the 10B(n,α)7Li nuclear reaction with minimal side effects on normal tissues.
Dachao Tang +7 more
wiley +1 more source
Advances in the Different Synthetic Routes of Fluorinated Hydrazines
The Chemical Record, EarlyView.This review highlights the various routes to the preparation of fluorinated hydrazines, thereby promoting the exploration of innovative methods for the synthesis of new N‐fluorinated hydrazines. Their synthesis mainly involves synthetic routes such as organometallic, organocatalytic, and photocatalytic.
Dimitra Kyrko, Benoît Crousse
wiley +1 more source
Andrology, EarlyView.ABSTRACT Background Infertility is a pressing global health concern, affecting one in six couples worldwide. The failure rate for assisted reproductive technologies (ART) cycles remains at approximately 78%, with limited improvements often attributed to a lack of technological innovation.
Mehran Dabiri +3 more
wiley +1 more source
Artificial Organs, EarlyView.The graphical abstract illustrates our rapid PI‐based spheroid viability assay: hepatocyte spheroids are formed and stained with AO/PI, imaged after a 15‐min incubation, and analyzed for PI brightness normalized to area. This metric correlates strongly with functional urea/DNA output, validating PI intensity as a fast, reliable indicator of spheroid ...
Michael G. Megaly +11 more
wiley +1 more source
Use of parallel fluorescent confocal microscopy for detection of prostatic adenocarcinoma
BJU International, EarlyView.Objective To provide a histological catalogue and defined criteria for the diagnosis of prostatic adenocarcinoma and its variants using the fluorescent confocal microscope (FCM) platform. Methods A total of 22 radical prostatectomy specimens were serially sectioned and scanned with the FCM.
Kevin Clare +13 more
wiley +1 more source
NUCLEIC-ACID BINDING DRUGS .2. PROFLAVINE FREE BASE [PDF]
, 1976 C13HIIN3.H20 , orthorhombic, Cmc21, a= 14.493 (8), b= 14.675 (8), c= 5.772 (5) A, Din= 1.29 (1), De= 1.298 g cm -3 for Z=4. Equi-inclination Weissenberg intensities, scanned with an automatic densitometer.
ACHARI, A, NEIDLE, S
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Same‐day fluorescence confocal microscopy of MRI‐targeted prostate biopsies: A feasibility study
BJU International, EarlyView.Objectives To determine the diagnostic performance of ex vivo fluorescence confocal microscopy (FCM) for prostate cancer detection in magnetic resonance imaging (MRI)‐targeted biopsy specimens using final histopathology as the reference standard, and to quantify workflow component times relevant to same‐day implementation.
Salim K. Younis +13 more
wiley +1 more source
Исследование реакций карбонильной группы в 1,2-дигидропирроло[з,2,1-de] акридин-6-оне [PDF]
, 2017 Проведено исследование возможности протекания реакций по карбонильной группе в гетероциклической системе l,2-дигидропирроло[з,2,l-de] акридин-6-она. Синтезированы новые производные этой гетероциклической системы - 6-имино-l,2-дигидропирроло[3,2,l-de ...
Алябьева, Т. М.
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