Results 31 to 40 of about 4,624 (225)
A facile synthesis of N-H-and N-substituted acridine-1,8-diones under sonic condition [PDF]
, 2013 Synthesis of an assembly of structurally important N-H- and N-substituted acridine-1,8-diones by CAN (ceric ammonium nitrate) catalysed one-pot four-component reaction of electron-deficient and electron-rich aromatic aldehydes and aromatic amines or ...
Pasha, M.A., Sudha, S.
core +3 more sources
Archaeometry, EarlyView., 2022 Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares +5 more
wiley +1 more source
Catalytic condensation for the formation of polycyclic heteroaromatic compounds
Nature Communications, 2018 The development of novel chemical reactions converting biomass-derived alcohols into important classes of compounds is a particularly attractive strategy.
Daniel Forberg +2 more
doaj +1 more source
G-quadruplexes and G-quadruplex ligands: targets and tools in antiviral therapy [PDF]
, 2018 G-quadruplexes (G4s) are non-canonical nucleic acids secondary structures that form within guanine-rich strands of regulatory genomic regions. G4s have been extensively described in the human genome, especially in telomeres and oncogene promoters; in ...
Richter, Sara N, Ruggiero, Emanuela
core +1 more source
Photodynamic inactivation of Candida albicans with imidazoacridinones : influence of irradiance, photosensitizer uptake and reactive oxygen species generation [PDF]
, 2015 The increasing applicability of antifungal treatments, the limited range of available drug classes and the emergence of drug resistance in Candida spp. suggest the need for new treatment options. To explore the applicability of C.
Bielawski, Krzysztof P. +4 more
core +12 more sources
Molecules, 2008 A series of 1-acyl-4-phenyl/(acridin-9-yl)thiosemicarbazides 3, including fournew compounds, were prepared in order to study substituent effects on cyclizationreactions with oxalyl chloride (producing imidazolidine-4,5-diones 4 ...
Karel D. Klika +7 more
doaj +1 more source
‘Acridines’ as New Horizons in Antifungal Treatment
Molecules, 2020 Frequent fungal infections in immunocompromised patients and mortality due to invasive mycosis are important clinical problems. Opportunistic pathogenic Candida species remain one of the leading causes of systemic mycosis worldwide.
Iwona Gabriel
doaj +1 more source
Stable σh-adducts in the reactions of the acridinium cation with heterocyclic N-nucleophiles [PDF]
, 2013 A reaction of NH-heterocycles with the 10-methylacridinium cation in the presence of a base led to 9,10-dihydro-10-methyl-9-substituted acridines, which can be considered as stable intermediates in the aromatic nucleophilic substitution reaction of ...
Budnikova, Y. G. +6 more
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Düzce Tıp Fakültesi DergisiAim: This study aimed to synthesize a novel pyrazole acridine derivative (3-ACH) and evaluate its anticancer properties on SH-SY5Y human neuroblastoma cells.Material and Methods: The pyrazole-4-carbaldehyde derivative was cyclized with dimedone and p ...
Muna Elmusa +5 more
doaj +1 more source
mAMSA resistant human topoisomerase IIbeta mutation G465D has reduced ATP hydrolysis activity [PDF]
, 2006 Type II Human DNA Topoisomerases (topos II) play an essential role in DNA replication and transcription and are important targets for cancer chemotherapeutic drugs.
Gilroy, Kathryn +4 more
core +3 more sources