Results 61 to 70 of about 4,624 (225)

Correlation between anti-malarial and anti-haemozoin activities of anti-malarial compounds

Malaria Journal, 2020
Background Despite noticeable improvement in anti-malarial treatment, rapid growth of resistant malaria strains points out the need for continuous development of novel anti-malarials to fight the disastrous infection.
Dao Ngoc Hien Tam, Gehad Mohamed Tawfik, Amr Ehab El-Qushayri, Ghaleb Muhammad Mehyar, Sedralmontaha Istanbuly, Sedighe Karimzadeh, Vo Linh Tu, Ranjit Tiwari, Truong Van Dat, Phuong Thuy Viet Nguyen, Kenji Hirayama, Nguyen Tien Huy   +11 more
doaj   +1 more source

Microfluidic Hydroporation Platform for Effective Allogeneic CAR‐T Cell Production and Subsequent Functional Cytotoxicity Analysis

Advanced Materials Technologies, EarlyView.
The hydroporator platform employs controlled hydrodynamic deformation for efficient mRNA and CRISPR/Cas9 delivery into primary human T cells, enabling allogeneic CAR‐T cell manufacturing. It preserves cell functionality and drives potent gene editing, CAR expression, and tumor cytotoxicity, while feature‐based analysis links these functional outcomes ...
Soohyun Jeon, Sein Kim, Hyun‐Young Kim, Duck Cho, Sungsu Park, Seohyun Kim, Aram J. Chung   +6 more
wiley   +1 more source

Efficient and Convenient Synthesis of 1,8-Dioxodecahydroacridine Derivatives Using Cu-Doped ZnO Nanocrystalline Powder as a Catalyst under Solvent-Free Conditions

The Scientific World Journal, 2013
A simple and convenient one-step method for synthesis of acridines and their derivatives from condensation of aromatic aldehydes, cyclic diketones, and aryl amines using Cu-doped ZnO nanocrystalline powder as a catalyst is reported.
Heshmatollah Alinezhad, Sahar Mohseni Tavakkoli   +1 more
doaj   +1 more source

Complexes of Pd(II) and Pt(II) with 9-aminoacridine: reactions with DNA and study of their antiproliferative activity

, 2013
Four new metal complexes {M = Pd(II) or Pt(II)} containing the ligand 9-aminoacridine (9AA) were prepared. The compounds were characterized by FT-IR and 1H, 13C, and 195Pt NMR spectroscopies. Crystal structure of the palladium complex of formulae [Pd(9AA)
Ciudad i Gómez, Carlos Julián, Font Bardia, Ma. Mercedes, Moreno Martínez, Virtudes, Noé Mata, Verónica, Riera, X., Solans, Xavier, 1949-2007   +5 more
core   +1 more source

1H NMR determination of the self-association of an acridine homodimer and its complexation with ethidium bromide in aqueous solution [PDF]

, 2006
1H NMR spectroscopy (500MHz) has been used to investigate the self-association in aqueous buffered solution of a bis-intercalator, Acridine Homodimer (AcrH), and its hetero-association with the aromatic dye, Ethidium Bromide (EB).
Barbet, Brana, Chaires, Chaires, D.B. Davies, Davies, Davies, Gaugain, Gaugain, Gaugain, Giessner-Prettre, Le Pecq, Lorente, M.P. Evstigneev, Piantanida, Ross, Suzuki, V.P. Evstigneev, Veal, Veselkov, Vitagliano, Wakelin, Waring   +22 more
core   +1 more source

Perfluorooctanoic Acid Exposure Causes Macrophage Ammonia Retention and Induces Spontaneous Miscarriages

Advanced Science, EarlyView.
PFOA exposure induces pregnancy loss by promoting glutaminolysis, which further causes ammonia accumulation in macrophages. Cellular ammonia retention results in damage to mitochondria and lysosomes, which leads to cell death eventually. Impaired lysosomes also decrease the secretion of the Cathepsin B (CTSB), and attenuate macrophage infiltration and ...
Yongbo Zhao, Yijun Zhang, Hanyu Rao, Jiani Sun, Zhiyi Pan, Liping Jin, Yan Zhao   +6 more
wiley   +1 more source

NUCLEIC-ACID BINDING-DRUGS .6. THE STRUCTURE OF 3,9-DIAMINO-7-ETHOXYACRIDINE (RIVANOL) AS THE LACTATE MONOHYDRATE SALT [PDF]

, 1982
C15H16N3 O+ • C3H50~-. H20, M r = 361.4, triclinic, Pi, with a = 7.912 (2), b = 10.016 (1), c = 12.246 (3)/k, = 107.75 (1),/~ = 103.08 (2), y = 94.47 (2) °, U = 888.9 ,/k 3, Z = 2, D m = 1.35 (2), D c = 1.350 Mg m -3, F(000) = 380, 2(Cu Ka) = 1.5418/~
AGGARWAL, A, NEIDLE, S
core  

Comparing Fragmentation Trees from Electron Impact Mass Spectra with Annotated Fragmentation Pathways [PDF]

, 2012
Electron impact ionization (EI) is the most common form of ionization for GC-MS analysis of small molecules. This ionization method results in a mass spectrum not necessarily containing the molecular ion peak.
Böcker, S., Hufsky, F.
core   +2 more sources

Alkyltriphenylphosphonium Binding to Cardiolipin Triggers Oncosis in Cancer Cells

Advanced Science, EarlyView.
Alkyltriphenylphosphonium, exemplified by TPP+‐C14, preferentially accumulates in mitochondria and selectively binds to cardiolipin, a key phospholipid of the inner mitochondrial membrane, causing loss of mitochondrial membrane potential, severe cellular ATP depletion, and calcium imbalance.
Jin Li, Hang Zheng, Yuxing Lin, Ziwei Zhao, Yijia Mai, Zhangrong Lou, Qiang Liu, Zhao Ma, Chengjun Wu   +8 more
wiley   +1 more source

Modelling the regulation of telomere length: the effects of telomerase and G-quadruplex stabilising drugs [PDF]

, 2013
Telomeres are guanine-rich sequences at the end of chromosomes which shorten during each replication event and trigger cell cycle arrest and/or controlled death (apoptosis) when reaching a threshold length.
A Canela, A Golubev, A Kowald, AE Bilsland, AJ Cesare, AJ Zaug, AM Zahler, Bartholomäus V. Hirt, BV Hirt, C Leonetti, C Schaffitzel, CJ Proctor, CJ Proctor, D Monchaud, E Henderson, EH Blackburn, F Wang, G Cristofari, G Wallweber, H Takai, HJ Lipps, I Rubelj, IA Rodriguez-Brenes, IA Sidorov, J Grasman, J Tang, JAD Wattis, JC Cookson, JD Griffith, Jonathan A. D. Wattis, K Masutomi, K Monier, KB Blagoev, L Hayflick, L Hayflick, L Oganesian, LA Johnson, M Gunaratnam, M Kimura, M Lei, M Macville, MA Collins, MK Cheng, MT Hemann, MT Teixeira, MZ Levy, N Arkus, NW Kim, O Arino, O Samassekou, O Wolkenhauer, P Abdallah, P Olofsson, P Olofsson, P Rosenau, P Wu, PD Sozou, PV Dmitriev, R Milo, RA Greenberg, RA Heald, RC Allsopp, S Neidle, SB Cohen, Simon P. Preston, SLB Knig, SM Gowan, SN Saldanha, SSS Poon, T Antal, T Lange de, T Lange de, T Lange de, T Richter, T Tauchi, T Zglinicki von, UM Martens, VL Makarov, W Palm, WE Wright, XY Dai, Y Xu, Y Zhao, Y Zhao   +83 more
core   +3 more sources