Results 71 to 80 of about 4,624 (225)

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Structure–Activity Relationship Studies of 9-Alkylamino-1,2,3,4-tetrahydroacridines against Leishmania (Leishmania) infantum Promastigotes

Pharmaceutics, 2023
Leishmaniasis is one of the most neglected diseases in modern times, mainly affecting people from developing countries of the tropics, subtropics and the Mediterranean basin, with approximately 350 million people considered at risk of developing this ...
Carlos F. M. Silva, Teresa Leão, Filipa Dias, Ana M. Tomás, Diana C. G. A. Pinto, Eduardo F. T. Oliveira, Ana Oliveira, Pedro A. Fernandes, Artur M. S. Silva   +8 more
doaj   +1 more source

Optical spectrum of proflavine and its ions

, 2010
Motivated by possible astrophysical and biological applications we calculate visible and near UV spectral lines of proflavine (C13H11N3, 3,6-diaminoacridine) in vacuum, as well as its anion, cation, and dication.
A. Bonaca, Bauschlicher, Becke, Castro, Castro, Clemett, De Silvestri, Destree, Ehrenfreund, G. Bilalbegović, Giannozzi, Godby, Herbig, Hirata, Hobbs, Hudgins, Jain, Jenniskens, Jones, Koch, Kokalj, Le Page, Lee, Lepp, Lerman, Malloci, Malloci, Marques, Martin, Mataga, Neumann, Perdew, Pileni, Rappe, Rocca, Runge, Sarre, Sarre, Sarre, Schulman, Snow, Thaddeus, Tielens, Tozzini, Troullier, Tuairisg, Varsano, Walker, Weisman, Yabana   +49 more
core   +1 more source

Disulfide‐Bridged Ru Complex–Mediated Photo‐Disulfidptosis for Colorectal Cancer Therapy

Advanced Science, EarlyView.
In this work, a binuclear ruthenium complex, RuSSRu was developed for efficient colorectal cancer (CRC) treatment. The synergistic interaction between disulfidptosis and lysosomal damage‐induced apoptosis induced by RuSSRu amplified tumor cell death. This innovative approach offers a potent therapeutic strategy for CRC.
Simeng He, Wendong Jin, Jiaojiao Pang, Xiaoting Gong, Shixian Cao, Duo Mao, Yuguo Chen, Kang‐Nan Wang, Bin Liu   +8 more
wiley   +1 more source

Diabetes Mellitus Facilitates Gallstone Formation Through CXCR2‐NETs–Mediated Liver‐Bile Barrier Damage

Advanced Science, EarlyView.
Diabetes is an independent risk factor for gallstones. It upregulates CXCR2 expression in hepatic neutrophils, stimulating the formation of NETs that disrupt hepatocellular tight junctions and the liver‐bile barrier. NETs enter bile to accelerate gallstone development, while sarcosine inhibits CXCR2 and NETs production, effectively reducing diabetes ...
Chao Shi, Shuo Feng, Tianming Liu, Ziang Meng, Yi Zheng, Zhenghao Huang, Tong Wang, Bojian Zhang, Dongbo Xue, Biao Ma, Xianzhi Meng   +10 more
wiley   +1 more source

High‐Efficiency TADF Dendritic Emitters Enabled by Synchronously Inhibiting Degenerated Triplet Excited States and Structural Relaxation Toward Solution‐Processed OLEDs with EQE Over 33%

Advanced Science, EarlyView.
Asymmetrical thermally activated delated fluorescence dendritic emitters are delicately constructed through symmetry breaking strategy, and near‐unity photoluminescence efficiency and excellent reverse intersystem crossing process are achieved via breaking the degeneracy of vibrational levels and boosting the spin flip of triplet excitons.
Xiaoxiang Yu, Wei Ping, Chengshuang Song, Jinyang Zhao, Lei Hua, Junjie Wang, Shian Ying, Yuchao Liu, Zhongjie Ren, Shouke Yan   +9 more
wiley   +1 more source

A facile and efficient synthesis of 1,8-dioxodecahydroacridines derivatives catalyzed by cobalt–alanine metal complex under aqueous ethanol media

BMC Chemistry, 2019
A facile and convenient method for the synthesis of acridines and its derivatives was developed through one-pot, three-component condensation reaction of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione, aryl amines or ammonium acetates in the ...
M. Mujahid Alam, Ahmed T. Mubarak, Mohammed A. Assiri, S. Merajuddin Ahmed, Ahmed M. Fouda   +4 more
doaj   +1 more source

A study of the feculae of Orthoptera, their specificity, and the role which the insects'mouthparts, alimentary canal, and food-habits play in their formation [PDF]

, 1962
2 láminasMany physiological studies have been carried out on different aspects of the feculae ("feces") and their formation in Orthoptera (sens. lat.).
Gangwere, S. K.
core  

Aggregation‐Induced Resonance Energy Transfer in Polymer Dots to Boost Electrochemiluminescence Performance for Bioimaging of Glycan on Cells

Advanced Science, EarlyView.
This study pioneers an aggregation‐induced resonance energy transfer mechanism by synergistically integrating aggregation‐induced emission (AIE), resonance energy transfer (RET), and thermally activated delayed fluorescence (TADF) within co‐reactant conjugated polymers to develop self‐enhanced ECL emitters, which achieves an ECL efficiency up to 92.6 ...
Chao Wang, Mengjiao Li, Yiran Li, Xiangfu Hu, Chunlan Li, Ningning Wang, Huangxian Ju   +6 more
wiley   +1 more source

The interactions of monomeric acridines and unsymmetrical bisacridines (UAs) with DNA duplexes: an insight provided by NMR and MD studies

Scientific Reports, 2023
Members of a novel class of anticancer compounds, exhibiting high antitumor activity, i.e. the unsymmetrical bisacridines (UAs), consist of two heteroaromatic ring systems.
Tomasz Laskowski, Michał Kosno, Witold Andrałojć, Joanna E. Frackowiak, Julia Borzyszkowska-Bukowska, Paweł Szczeblewski, Nikola Radoń, Maria Świerżewska, Anna Woźny, Ewa Paluszkiewicz, Zofia Mazerska   +10 more
doaj   +1 more source