Results 11 to 20 of about 77,401 (163)

Studies Directed towards the Synthesis of the Acridone Family of Natural Products: Total Synthesis of Acronycines and Atalaphyllidines. [PDF]

ACS Omega, 2021
A modular and flexible three-step synthetic strategy has been developed for the synthesis of acridone natural products of biological significance. The tetracyclic core of acridone derivatives has been achieved efficiently in high yield from commercially ...
Mandal T, Karmakar S, Kapat A, Dash J.
europepmc   +4 more sources

N-Aryl Acridone Derivatives as Effective Catalysts for Energy Transfer Reactions. [PDF]

Chemistry
Acridones derivatives have high triplet energy, are simple accessible, and could be used in challenging [2+2] ENT reactions. ABSTRACT Organic photocatalysts capable of promoting high‐energy triplet energy transfer (EnT) remain limited, particularly for demanding [2+2] photocycloaddition reactions.
Calogero F, D'Onghia G, Fina F, Ziani Z, Sensoli L, Gualandi A, Fermi A, Ceroni P, Cozzi PG.   +8 more
europepmc   +2 more sources

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities. [PDF]

Chem Biodivers
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
Castro JWG, Souza GGO, da Costa JGM, Rodrigues FFG.   +3 more
europepmc   +2 more sources

Antioxidant Chemistry of Phenolics in Chinese Herbal Medicines: A Holism-Based Review. [PDF]

Chem Biodivers
Phenolic antioxidants in CHMs mainly include chalcone, stilbene, flavonoid, xanthone, and Diels–Alder‐type adducts. They undergo direct and indirect pathways to exert antioxidant action. The indirect pathway is transition metal‐chelating, while the direct pathway comprises several redox‐based reactions (e.g., SET and HAT) and RAF reactions.
Li X.
europepmc   +2 more sources

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases. [PDF]

FEBS J
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Sokolova N, Osipyan A, Zhang L, Groves MR, Schmidt S, Haslinger K.   +5 more
europepmc   +2 more sources

Sustainable Production of N-methylphenylalanine by Reductive Methylamination of Phenylpyruvate Using Engineered Corynebacterium glutamicum

Microorganisms, 2021
N-alkylated amino acids occur widely in nature and can also be found in bioactive secondary metabolites such as the glycopeptide antibiotic vancomycin and the immunosuppressant cyclosporine A.
Anastasia Kerbs, Melanie Mindt, Lynn Schwardmann, Volker F. Wendisch   +3 more
doaj   +1 more source

Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae) [PDF]

, 2017
Atangana AF, Toze FAA, Langat MK, et al. Acridone alkaloids from Vepris verdoorniana (Excell & Mendonca) Mziray (Rutaceae). Phytochemistry Letters. 2017;19:191-195.Two new acridone alkaloids, verdoocridone A (1) and B (4), together with fifteen known
Langat, Moses, Waffo, AFK, Wansi, JD, Sewald, N, Toze, FAA, Meva’a Mbazea, LL, Mulholland, Dulcie, Atangana, AF, Happi, EN, Waffo, Alain Francois Kamdem, Sewald, Norbert ; https://orcid.org/, Wansi, Jean Duplex, Toze, Flavien Aristide Alfred, Atangana, Albert Fouda, Langat, Moses K., Happi, Emmanuel Ngeufa, Mulholland, Dulcie A., Mbaze, Luc Leonard Meva'a   +17 more
core   +2 more sources

ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V

Química Nova, 2016
Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies.
Emerson F. Marques, Paulo C. Vieira, Richele P. Severino   +2 more
doaj   +1 more source

Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies

Journal of Chemistry, 2022
The phytochemical investigations of the methanol extract of Zanthoxylum gilletii bark led to the isolation of thirteen compounds identified as two alkaloids including one acridone 5-hydroxynoracronycine (1) and one benzo [c] phenanthridine decarine (2 ...
Liliane Clotilde Dzouemo, Gervais Mouthé Happi, Sikiru Akinyeye Ahmed, Willifred Dongmo Tekapi Tsopgni, Michael Nde Akuma, Shina Salau, Emmanuel Ngeufa Happi, Jean Duplex Wansi   +7 more
doaj   +1 more source

Antioxidant Profiling of Glycosmis cyanocarpa: In Vitro Assays and Pearson's Correlation Study. [PDF]

Biomed Res Int
Oxidative stress is a major contributor to the development of various chronic illnesses, making the evaluation of plant‐derived antioxidants a crucial step in the search for novel therapeutic agents. Glycosmis cyanocarpa (Blume) Spreng., a relatively underexplored species native to South and Southeast Asia, has shown potential as a natural antioxidant ...
Ashrafi S, Mina ST, Jebin RH, Ahmed F.
europepmc   +2 more sources