Results 11 to 20 of about 458 (131)

Citrus reticulata Blanco: A Review on Chemical Composition and Biological Activities. [PDF]

Chem Biodivers
This review compiles chemical information and biological activities from 49 studies on Citrus reticulata. The fruit peels stand out for their high content of methoxylated monoterpenes and flavonoids with antioxidant, anti‐inflammatory, and antimicrobial activities.
Castro JWG, Souza GGO, da Costa JGM, Rodrigues FFG.   +3 more
europepmc   +2 more sources

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases. [PDF]

FEBS J
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Sokolova N, Osipyan A, Zhang L, Groves MR, Schmidt S, Haslinger K.   +5 more
europepmc   +2 more sources

Investigation on Anti-Diarrheal and Antipyretic Activities of <i>citrus maxima</i> Seeds in Swiss Albino Mice Model. [PDF]

Food Sci Nutr
A novel preliminary research work to find out the pharmacological potentials of Citrus maxima seeds on mice model. This research will add a new way towards the discovery of herbal medicine to aid in human life. ABSTRACT In the Rutaceae family Citrus maxima is the biggest among all fruits, tradtionally used for several purposes due to its diverse ...
Ahsan T, Maria NN, Jasmin AA, Tahmida U, Singha S.   +4 more
europepmc   +2 more sources

Alkaloid profile of Italian alpine milk. [PDF]

J Food Sci
Abstract This study examines the alkaloid profiles in alpine milk. Alkaloids could pose a health concern but also prove interesting from a geographic traceability perspective. Over three consecutive days, 48 daily milk samples were collected from 16 lactating cows grazing on two alpine pastures in Northeast Italy, with 8 cows from each pasture ...
Nardin T, Piasentier E, Romanzin A, Martinelli F, Larcher R.   +4 more
europepmc   +2 more sources

Oxidative Dehydrogenation of N-Heteroaromatic Alkyl Alcohols and Amines Facilitated by Dearomative Tautomerization. [PDF]

Chemistry
N‐heteroaromatic alkyl alcohols and amines are inherently unstable in acidic and/or basic solution due to an irreversible dehydrogenation that proceeds from a minority tautomer. In many cases, this reaction results in quantitative oxidation to the corresponding aldehyde, providing a simple, convenient, and green approach for preparing versatile ...
Ghasemloo O, Hasselbrink CL, Cardona DD, DeBoef B, Hayes D.   +4 more
europepmc   +2 more sources

Expanding the Substrate Scope of N‐ and O‐Methyltransferases from Plants for Chemoselective Alkylation**

ChemCatChem, Volume 15, Issue 22, November 22, 2023., 2023
Chemoselective S‐adenosyl‐l‐methionine (SAM)‐dependent methyltransferases (MTs) are a promising alternative to traditional synthetic methylation reactions. In presence of multiple nucleophiles, the enzymatic transfer of the carbon fragment is highly chemoselective for N‐ and O‐MTs.
Emely Jockmann, Fabiana Subrizi, Michael K. F. Mohr, Eve M. Carter, Pia M. Hebecker, Désirée Popadić, Helen C. Hailes, Jennifer N. Andexer   +7 more
wiley   +1 more source

Advances in the natural α‐glucosidase inhibitors

eFood, Volume 4, Issue 5, October 2023., 2023
Natural products are a great source for the development of new α‐glucosidase (AG) inhibitory drug candidates. We aim to summarize advances in natural AG inhibitors according to their secondary metabolite groups in the last decade. Their mechanisms of action and structure–activity relationships will especially be discussed.
Didem Şöhretoğlu, Gülin Renda, Randolph Arroo, Jianbo Xiao, Suat Sari   +4 more
wiley   +1 more source

Chemical Constituents of the Bark of Zanthoxylum gilletii (Rutaceae) and Their In Vitro Antiplasmodial and Molecular Docking Studies

Journal of Chemistry, 2022
The phytochemical investigations of the methanol extract of Zanthoxylum gilletii bark led to the isolation of thirteen compounds identified as two alkaloids including one acridone 5-hydroxynoracronycine (1) and one benzo [c] phenanthridine decarine (2 ...
Liliane Clotilde Dzouemo, Gervais Mouthé Happi, Sikiru Akinyeye Ahmed, Willifred Dongmo Tekapi Tsopgni, Michael Nde Akuma, Shina Salau, Emmanuel Ngeufa Happi, Jean Duplex Wansi   +7 more
doaj   +1 more source

Organophotocatalytic Mechanisms: Simplicity or Naïvety? Diverting Reactive Pathways by Modifications of Catalyst Structure, Redox States and Substrate Preassemblies

ChemCatChem, Volume 15, Issue 11, June 9, 2023., 2023
Organophotocatalysis: Which pathway to go? This review exemplifies influences of organophotocatalyst structural and redox programming, to select for a particular excited‐state mechanism among a diversity of potential mechanisms. It showcases how such strategies are exploited for catalyst‐substrate preassemblies that overcome common reactivity issues ...
Mark John P. Mandigma, Jaspreet Kaur, Joshua P. Barham   +2 more
wiley   +1 more source

ALCALOIDES ACRIDÔNICOS INIBEM CATEPSINA L E V

Química Nova, 2016
Cathepsins represent a class of enzymes that has the primary function of randomly degrading proteins in the lysosomes, although are also involved in different pathologies.
Emerson F. Marques, Paulo C. Vieira, Richele P. Severino   +2 more
doaj   +1 more source