Results 31 to 40 of about 458 (131)

New acridone alkaloids from Ugandan Vepris trichocarpa

Scientific African
Ugandan Vepris trichocarpa sampled for this study yielded two undescribed acridone alkaloids here named trichouganda A (1), a 2‑methoxy derivative of evoxanthine (2), and trichouganda B (4), a 6‑methoxy derivative of 1,3,5-trimethoxy-10-methyl acridone ...
Papin Mucaleque, Moses K. Langat, Eduard Mas-Claret, Martin Cheek, Iain Darbyshire   +4 more
doaj   +1 more source

Acridone alkaloids from Zanthoxylum zanthoxyloides exhibit in vitro anti-Candida, anti-biofilm and antifungal-resistance-modifying activities against drug-Resistant Candida albicans, Candida glabrata and other non-albicans Candida species

Results in Chemistry
Candida infections pose a growing global health threat, with high mortality rates driven by multidrug-resistant (MDR) strains, and a limited number of antifungals in the pipeline.
Benjamin Kingsley Harley, Maudesta Opoku, Theophilus Duku Asamoah, Angelina Efia Mantey, Inemesit Okon Ben, Jonathan Jato, Mike Okweesi Aggrey, Nii Korley Kortei, Theophilus Christian Fleischer   +8 more
doaj   +1 more source

Stereoretentive Nucleophilic Aromatic Substitution Accesses Atropisomeric 4‐Amino‐N‐Arylquinolinium Salts

Chemistry – A European Journal, EarlyView.
Quinolin‐4‐ones were converted to chloroquinolinium salts, allowing formation of axially chiral aminoquinolinium salts via an enantioretentive SNAr reaction with a variety of amine nucleophiles. The salts have a high rotational barrier, with a racemization half‐life of ∼1000s of years.
Darren Holmes, Nia Foster, Saima Ansari, Paul Kavanagh, Paul Dingwall, Peter C. Knipe   +5 more
wiley   +1 more source

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Anion‐π+ Type AIE‐Active Photosensitizers for Ferroptosis‐Driven Photodynamic Immunotherapy Against Hypoxic Solid Tumors

Aggregate, Volume 7, Issue 1, January 2026.
An anion‐π+ type AIE photosensitizer (TMTPA NPs) with NIR emission was successfully developed through a sulfidation strategy. With its exceptional mitochondrial targeting abilities and efficient Type I ROS generation, TMTPA NPs effectively trigger ferroptosis.
Lingxiu Liu, Jianye Gong, Xue Wang, Ying Zhang, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang   +6 more
wiley   +1 more source

Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies

Phytotherapy Research, Volume 39, Issue 10, Page 4444-4473, October 2025.
NPs improve atopic dermatitis mainly include flavonoids, phenols, glycosides, alkaloids, and others. ABSTRACT Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden.
Xinyun Fan, Zibo Liu, Wenjing Yang, Hongying Zhang, Hao Zhong, Yan Pang, Xun Ye, Chunjie Wu, Liang Li   +8 more
wiley   +1 more source

Unusual N-acetoxymethyl derivatives of flindersine and acridone alkaloids from Kenyan Vepris glandulosa and V. hanangensis var unifoliata and their inhibitory effects against HIV 1 reverse transcriptase

Scientific African
The leaves of Vepris glandulosa gave ten compounds, nine known, flindersine (1a), 7-methoxyflindersine (1b), 7-prenyloxyflindersine (3), toddaliopsin C (4), xanthoxoline (5), arborinine (6), lupeol, sitosterol and pheophytin a, and one previously ...
Carlotta Zamboni, Fatima Iganya Suleiman, Eduard Mas-Claret, Sajni Shah, Martin Cheek, Quentin Luke, Sani M. Isyaka, Moses K. Langat   +7 more
doaj   +1 more source

Indoloquinoline Alkaloids as Antimalarials: Advances, Challenges, and Opportunities

ChemMedChem, Volume 19, Issue 18, September 16, 2024.
Extracts from the plant C. sanguinolenta and the isolated indoloquinoline alkaloids have been found to possess potent antimalarial activities, in vitro and in vivo, against various strains of P. falciparum. Structure‐activity relationship studies identified more potent analogs.
Prakash T. Parvatkar, Khaly Diagne, Yingzhao Zhao, Roman Manetsch   +3 more
wiley   +1 more source

Acridone alkaloids

The Alkaloids: Chemistry and Biology, 2000
Skaltsounis, A.L., Mitaku, S., Tillequin, F.   +2 more
openaire   +2 more sources