Results 41 to 50 of about 77,401 (163)

Integrative Insights Into DYRK1A From Molecular Function to Therapeutic Advancement

Chemical Biology &Drug Design, Volume 108, Issue 1, July 2026.
At the center the 3D structure of DYRK1A has been displayed. The dual‐function of DYRK1A involved in cancer and neurodegeneration, i.e., its overexpression drives Down syndrome, neurodegenerative disease etc., and underexpression causes intellectual disability, seizures, etc.
Sampriti Paul, Sonal Dubey, Prashant Tiwari   +2 more
wiley   +1 more source

Studies using radioisotopes. III. The biosynthesis of acridone alkaloids

, 1969
The biosynthesis of acridone alkaloids has been investigated in Acronychia baueri and Evodia xanthoxyloides. Anthranilic acid, N- methylanthranilic acid (XI), acetate, and 4-hydroxy-N-methylquinol-2- one (X) are incorporated, and tryptophan appears not ...
RH Prager, HM Thredgold
core   +1 more source

O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae)

, 2011
Happi EN, Waffo AFK, Wansi JD, Ngadjui BT, Sewald N. O-Prenylated Acridone Alkaloids from the Stems of Balsamocitrus paniculata (Rutaceae). Planta Medica. 2011;77(09):934-938.Two new O-prenylated acridone alkaloids, balsacridone A (1) and B (2), together
Waffo, Alain Francois Kamdem, Wansi, Jean Duplex, Emmanuel Happi, Ngadjui, Bonaventure Tchaleu, Alain Waffo, Norbert Sewald, Bonaventure Ngadjui, Happi, Emmanuel Ngeufa, Sewald, Norbert ; https://orcid.org/, Jean Wansi   +9 more
core   +1 more source

Alkaloids of Atalantia monophylla correa

, 1970
Atalaphylline and N-methylatalaphylline, two new acridone alkaloids isolated from Atalantia monophylla, have been shown to have structures (IVa) and (IVb ...
N. Viswanathan, B.R. Pai, Govindachari, T. R., P.S. Subramaniam, Pai, B. R., Subramaniam, P. S., V.N. Ramachandran, T.R. Govindachari, Viswanathan, N., Ramachandran, V. N.   +9 more
core   +1 more source

Boron Neutron Capture Therapy at a Crossroads: Translational Gap and Emerging Delivery Agents

Chemistry – A European Journal, Volume 32, Issue 17, 5 May 2026.
This review surveys recent advances in boron delivery agents for BNCT, emphasizing the shift from classical small molecules to multifunctional nanocarriers and theranostic systems. By integrating targeting, imaging, and therapy, next‐generation boron compounds aim to bridge the gap between (bio)chemical innovation and clinical translation.
Christoph Selg, Evamarie Hey‐Hawkins
wiley   +1 more source

Anionic N-Fries Rearrangement of N-Carbamoyl Diarylamines to Anthranilamides. Methodology and Application to Acridone and Pyranoacridone Alkaloids

, 2016
A general alkyllithium/LDA-mediated rearrangement of N-carbamoyl diarylamines 7a−g into the anthranilamides 8a−g and 9a−g (Table ) is presented and applied to a regioselective efficient construction of acridone (17) and pyranoacridone (18) alkaloids ...
Victor Snieckus (266177), Brian J. Wilson (216289), Stephen L. MacNeil (1949737)   +2 more
core   +1 more source

Anion‐π+ Type AIE‐Active Photosensitizers for Ferroptosis‐Driven Photodynamic Immunotherapy Against Hypoxic Solid Tumors

Aggregate, Volume 7, Issue 1, January 2026.
An anion‐π+ type AIE photosensitizer (TMTPA NPs) with NIR emission was successfully developed through a sulfidation strategy. With its exceptional mitochondrial targeting abilities and efficient Type I ROS generation, TMTPA NPs effectively trigger ferroptosis.
Lingxiu Liu, Jianye Gong, Xue Wang, Ying Zhang, Guoyu Jiang, Jianguo Wang, Ben Zhong Tang   +6 more
wiley   +1 more source

Acridone Alkaloids from Glycosmis chlorosperma as DYRK1A Inhibitors

, 2016
Two new acridone alkaloids, chlorospermines A and B (1 and 2), were isolated from the stem bark of Glycosmis chlorosperma, together with the known atalaphyllidine (3) and acrifoline (4), by means of bioguided isolation using an in vitro enzyme assay ...
Erell Le Borgne (1800952), Nadège Loaëc (1356108), Bogdan I. Iorga (1366392), Laurent Meijer (243859), Olivier Lozach (1291761), Marc Litaudon (523316), Khalijah Awang (236138), Mehdi A. Beniddir (1743124)   +7 more
core   +1 more source

Unusual N-acetoxymethyl derivatives of flindersine and acridone alkaloids from Kenyan Vepris glandulosa and V. hanangensis var unifoliata and their inhibitory effects against HIV 1 reverse transcriptase

Scientific African
The leaves of Vepris glandulosa gave ten compounds, nine known, flindersine (1a), 7-methoxyflindersine (1b), 7-prenyloxyflindersine (3), toddaliopsin C (4), xanthoxoline (5), arborinine (6), lupeol, sitosterol and pheophytin a, and one previously ...
Carlotta Zamboni, Fatima Iganya Suleiman, Eduard Mas-Claret, Sajni Shah, Martin Cheek, Quentin Luke, Sani M. Isyaka, Moses K. Langat   +7 more
doaj   +1 more source

Advances in Atopic Dermatitis Treatment: From Pathogenesis to Natural Product‐Based Therapies

Phytotherapy Research, Volume 39, Issue 10, Page 4444-4473, October 2025.
NPs improve atopic dermatitis mainly include flavonoids, phenols, glycosides, alkaloids, and others. ABSTRACT Atopic dermatitis (AD), a widespread and chronic inflammatory skin disorder, profoundly affects patients' quality of life, imposes significant psychological strain, and adds to the public health burden.
Xinyun Fan, Zibo Liu, Wenjing Yang, Hongying Zhang, Hao Zhong, Yan Pang, Xun Ye, Chunjie Wu, Liang Li   +8 more
wiley   +1 more source