Results 51 to 60 of about 38,436 (213)

Incidence of bronchiectasis in patients with acromegaly: a cohort study

Frontiers in Endocrinology
ObjectiveAssociations between acromegaly and several respiratory diseases, such as obstructive lung disease or sleep apnea, have been suggested, but the relationship between bronchiectasis and acromegaly is unclear.
Hyun-Il Gil, Kyungdo Han, Sangmo Hong, Cheol-Young Park   +3 more
doaj   +1 more source

Epidemiology of acromegaly: review of population studies

Pituitary, 2016
Acromegaly is a rare condition necessitating large population studies for the generation of reliable epidemiological data. In this review, we systematically analysed the epidemiological profile of this condition based on recently published population ...
Aikaterini Lavrentaki, A. Paluzzi, J. Wass, N. Karavitaki   +3 more
semanticscholar   +1 more source

Treatment of Acromegalic Osteopathy in Real-Life Clinical Practice: The BAAC (Bone Active drugs in ACromegaly) Study.

Journal of Clinical Endocrinology and Metabolism, 2020
BACKGROUND Vertebral fractures (VFs) are a frequent complication of acromegaly, but no studies have been so far published on effectiveness of anti-osteoporotic drugs in this clinical setting. OBJECTIVE To evaluate whether in real-life clinical practice
G. Mazziotti, C. Battista, F. Maffezzoni, S. Chiloiro, E. Ferrante, N. Prencipe, L. Grasso, F. Gatto, R. Olivetti, M. Arosio, Marco Barale, A. Bianchi, M. Cellini, I. Chiodini, L. De Marinis, G. Del Sindaco, C. Di Somma, A. Ferlin, E. Ghigo, A. Giampietro, S. Grottoli, E. Lavezzi, G. Mantovani, E. Morenghi, R. Pivonello, T. Porcelli, M. Procopio, F. Pugliese, A. Scillitani, A. Lania   +29 more
semanticscholar   +1 more source

Oral paltusotine, a nonpeptide selective somatostatin receptor 2 agonist: Mass balance, absolute bioavailability and metabolism in healthy participants

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims Paltusotine is a novel, nonpeptide, selective somatostatin receptor 2 agonist in development for the treatment of acromegaly and carcinoid syndrome. This study investigated the mass balance, routes of excretion, absolute bioavailability and metabolite profile of orally administered paltusotine.
Rosa Luo, Ajay Madan, Christine T. Ferrara‐Cook, Deepak Dalvie, Lance Goulet, R. Scott Struthers, Alan S. Krasner   +6 more
wiley   +1 more source

Guidelines on diagnostics and treatment of acromegaly (draft)

Ожирение и метаболизм
We recommend acromegaly to be ruled in all patients with characteristic changes in appearance (A3). In all patients without characteristic changes in appearance, we recommend to rule out acromegaly, if several clinical signs suspicious for acromegaly are
E. G. Przhiyalkovskaya, N. G. Mokrysheva, E. A. Troshina, G. A. Melnichenko, I. I. Dedov, M. B. Antsiferov, L. I. Astafieva, T. P. Bardymova, Zh. E. Belaya, G. R. Vagapova, S. Yu. Vorotnikova, A. Yu. Grigoriev, E. N. Grineva, L. K. Dzeranova, I. A. Ilovaiskaya, P. L. Kalinin, A. M. Lapshina, A. S. Lutsenko, E. O. Mamedova, E. I. Marova, M. A. Perepelova, E. A. Pigarova, V. S. Pronin, L. Ya. Rozhinskaya, Yu. Yu. Trunin, A. S. Shutova   +25 more
doaj   +1 more source

A Zebrafish Acromegaly Model Elevates DNA Damage and Impairs DNA Repair Pathways

Biology, 2018
Acromegaly is a pathological condition due to excess growth hormone (GH) secretion. Acromegaly patients exhibit a deterioration of health and many associated complications, such as cardiovascular issues, arthritis, kidney diseases, muscular weakness, and
Abdalla Elbialy, Shuichi Asakawa, Shugo Watabe, Shigeharu Kinoshita   +3 more
doaj   +1 more source

Cancer Incidence in Patients With Acromegaly: A Cohort Study and Meta-Analysis of the Literature

Journal of Clinical Endocrinology and Metabolism, 2018
Context Acromegaly has been associated with increased risk of cancer morbidity and mortality, but research findings remain conflicting and population-based data are scarce.
J. Dal, Michelle Z. Leisner, Kasper Hermansen, D. Farkas, M. Bengtsen, C. Kistorp, E. H. Nielsen, M. Andersen, U. Feldt-Rasmussen, O. Dekkers, H. Sørensen, J. Jørgensen   +11 more
semanticscholar   +1 more source

Annual Banned‐Substance Review 17th Edition—Analytical Approaches in Human Sports Drug Testing 2023/2024

Drug Testing and Analysis, EarlyView.
Scenarios of drug exposure and administration as well as detection assays for drugs and methods of sports doping published between 2023 and 2024 are critically reviewed and evaluated in context with the Prohibited List 2024 as established by the World Anti‐Doping Agency.
Mario  Thevis, Tiia  Kuuranne, Hans  Geyer   +2 more
wiley   +1 more source

Hip Structure Analyses in Acromegaly: Decrease of Cortical Bone Thickness After Treatment: A Longitudinal Cohort Study

JBMR Plus, 2019
Long‐standing growth hormone (GH) excess causes the skeletal clinical signs of acromegaly with typical changes in bone geometry, including increased cortical bone thickness (CBT).
Kristin Godang, Tove Lekva, Kjersti Ringvoll Normann, Nicoleta Cristina Olarescu, Kristin Astrid Berland Øystese, Anders Kolnes, Thor Ueland, Jens Bollerslev, Ansgar Heck   +8 more
doaj   +1 more source

Automatic Detection for Acromegaly Using Hand Photographs: A Deep-Learning Approach

IEEE Access, 2021
Machine learning assisted diagnosis of acromegaly from facial photographs has been proved feasible in recent years. According to our previous research, facial and limb changes exist in patients with acromegaly at early stage.
Chengbin Duan, Wenli Chen, Shun Yao, Zhigang Mao, Zongming Wang, Bin Hu, Haosen Jiao, Dimin Zhu, Yonghong Zhu, Haijun Wang   +9 more
doaj   +1 more source