Results 91 to 100 of about 178 (148)

Genome-wide identification and stress-responsive expression analysis of the Actin-Depolymerizing Factor (ADF) gene family in Avena sativa L

BMC Plant Biology
Background Oat (Avena sativa L.) is an important cereal crop globally, valued for both its grain and forage. Actin depolymerization factors (ADFs) are highly conserved eukaryotic proteins that facilitate remodeling of the actin cytoskeleton. Accumulating
Deying Wang, Tao Liu, Wenhui Tian, Hong Chen, Guoqing Wang, Bo Zhang   +5 more
doaj   +1 more source

Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response

Glia, Volume 74, Issue 9, September 2026.
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala, Alvaro Bautista‐Abad, Daniel Pinto‐Benito, Julia Simon‐Areces, Daniela Grassi, Francesco Paolo Ulloa Severino, Maria‐Angeles Arevalo   +6 more
wiley   +1 more source

Plasma Gelsolin Levels Decrease in Diabetic State and Increase upon Treatment with F-Actin Depolymerizing Versions of Gelsolin

Journal of Diabetes Research, 2014
The study aims to map plasma gelsolin (pGSN) levels in diabetic humans and mice models of type II diabetes and to evaluate the efficacy of gelsolin therapy in improvement of diabetes in mice. We report that pGSN values decrease by a factor of 0.45 to 0.5
Neeraj Khatri, Amin Sagar, Nagesh Peddada, Vikas Choudhary, Bhupinder Singh Chopra, Veena Garg, Renu Garg, Ashish   +7 more
doaj   +1 more source

Epidermal Growth Factor Receptor-PI3K Signaling Controls Cofilin Activity To Facilitate Herpes Simplex Virus 1 Entry into Neuronal Cells

mBio, 2014
Herpes simplex virus type 1 (HSV-1) establishes latency in neurons and can cause severe disseminated infection with neurological impairment and high mortality.
Kai Zheng, Yangfei Xiang, Xiao Wang, Qiaoli Wang, Meigong Zhong, Shaoxiang Wang, Xiaoyan Wang, Jianglin Fan, Kaio Kitazato, Yifei Wang   +9 more
doaj   +1 more source

Functional Specialization of Clathrin‐Independent Endocytic Routes: Mechanisms and Cellular Roles

Traffic, Volume 27, Issue 3, September 2026.
Distinct clathrin‐independent endocytic (CIE) routes support specialized cellular functions across different contexts. Created with Biorender.com. ABSTRACT Clathrin‐independent endocytosis (CIE) comprises a diverse repertoire of internalization mechanisms that operate in parallel with clathrin‐mediated endocytosis.
Andrea Francesco Benvenuto, Amir Fardin, Matteo Balestra, Pier Paolo Di Fiore, Chiara Tordonato, Sara Sigismund   +5 more
wiley   +1 more source

Dual Cytoplasmic and Chloroplastic Mechanisms Fine‐Tune Chloroplast Division through ARC3 Protein Stability

Advanced Science, Volume 13, Issue 45, 13 August 2026.
ARC3 levels are controlled by cytosolic and chloroplast proteolytic systems. PUB52 mediates ARC3 precursor ubiquitination and degradation in the cytosol, while CLPC1 promotes ARC3 degradation in chloroplasts, where ARC2 protects ARC3 from excessive breakdown. Disrupting these components causes chloroplast division defects, placing them upstream of ARC3.
Yang Yuan, Denghao Xiang, Ruiying Li, Zhichuang Yue, Zhipeng Wang, Honghong Hu   +5 more
wiley   +1 more source

Inhibition of Moesin and CD44 in stem cell‐derived neurons affects the pathological genetic signature associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION Post mortem proteomic analysis of Alzheimer's disease (AD) brain tissue has identified novel target genes and proteins for potential therapeutic development. Moesin (MSN) and CD44 were identified as candidate targets. Using human induced pluripotent stem cells (hiPSCs)‐derived neurons, we assayed how reducing gene expression of ...
Eiden H. Brewer, Charles A. Williams, Gregory A. Cary, Ranjita Betarbet, Inez K. A. Pranoto, Elizabeth L. Zoeller, Haian Fu, Allan I. Levey, Jesse C. Wiley, Gregory W. Carter, Jessica E. Young, for the TREAT‐AD Consortium   +11 more
wiley   +1 more source

The Mechanobiology of Adipocyte Hypertrophy: Cytoskeletal Remodelling as a Driver of Insulin Resistance in Obesity

Cell Biochemistry and Function, Volume 44, Issue 8, August 2026.
ABSTRACT Adipocyte hypertrophy poses an important mechanical challenge—adipocytes can increase in volume up to a thousand‐fold while still maintaining their structural integrity. Although lipid metabolism is well studied, little is known about the cytoskeletal adaptations that are required to accommodate this expansion and the resulting pathological ...
Dhakshmi Sasankan, Renu Mohan
wiley   +1 more source

Membrane localization of a novel regulator of actin depolymerizing factor (ADF)

The FASEB Journal, 2012
Actin filament turnover is required for many actin‐dependent cellular processes including cell motility and membrane trafficking. Members of the actin depolymerizing factor/cofilin (ADF) family of actin binding proteins are essential for severing/depolymerizing actin filaments.
Katrina K Cuddy, Paris H Grey, Xiaoguo Zhang, David G Oppenheimer   +3 more
openaire   +1 more source

Keratan Sulfate: An Electroconductive Glycosaminoglycan at the Interface of Sensory Perception and Neural Signaling

Journal of Neuroscience Research, Volume 104, Issue 8, August 2026.
Laboratory studies show KS has electroconductive properties with the ability to trap and transport protons in neurotransductive processes (Grotthuss proton shuttling). This maintains electrochemical gradients and fluxes at the neuronal cell surface in neural activation. Such processes are central to neuronal cell signaling and communication.
James Melrose
wiley   +1 more source