Results 31 to 40 of about 178 (148)

Human plasma actin‐depolymerizing factor [PDF]

European Journal of Biochemistry, 1985
The plasma and serum of humans and various animal species exert an actin‐depolymerizing activity. Human actin‐depolymerizing factor (ADF) has been purified by ammonium sulfate fractionation, DEAE‐cellulose and blue‐Sepharose chromatography. It is a single polypeptide of approximately 90 kDa, with a pI between 6.0 and 6.5.
Chaponnier, Christine, Patebex, P., Gabbiani, Giulio   +2 more
openaire   +3 more sources

Phylogenetic Patterns of Codon Evolution in the ACTIN-DEPOLYMERIZING FACTOR/COFILIN (ADF/CFL) Gene Family. [PDF]

PLoS ONE, 2015
The actin-depolymerizing factor/cofilin (ADF/CFL) gene family encodes a diverse group of relatively small proteins. Once known strictly as modulators of actin filament dynamics, recent research has demonstrated that these proteins are involved in a ...
Eileen M Roy-Zokan, Kelly A Dyer, Richard B Meagher   +2 more
doaj   +1 more source

Glucocorticoids Preferentially Influence Expression of Nucleoskeletal Actin Network and Cell Adhesive Proteins in Human Trabecular Meshwork Cells

Frontiers in Cell and Developmental Biology, 2022
Clinical use of glucocorticoids is associated with increased intraocular pressure (IOP), a major risk factor for glaucoma. Glucocorticoids have been reported to induce changes in actin cytoskeletal organization, cell adhesion, extracellular matrix ...
William Bachman, Rupalatha Maddala, Ayon Chakraborty, Camelia Eldawy, Nikolai P. Skiba, Ponugoti V. Rao, Ponugoti V. Rao   +6 more
doaj   +1 more source

Actin-depolymerizing Factor and Cofilin-1 Play Overlapping Roles in Promoting Rapid F-Actin Depolymerization in Mammalian Nonmuscle Cells [PDF]

Molecular Biology of the Cell, 2005
Actin-depolymerizing factor (ADF)/cofilins are small actin-binding proteins found in all eukaryotes. In vitro, ADF/cofilins promote actin dynamics by depolymerizing and severing actin filaments. However, whether ADF/cofilins contribute to actin dynamics in cells by disassembling “old” actin filaments or by promoting actin filament assembly through ...
Pirta, Hotulainen, Eija, Paunola, Maria K, Vartiainen, Pekka, Lappalainen   +3 more
openaire   +2 more sources

Sizes of actin networks sharing a common environment are determined by the relative rates of assembly.

PLoS Biology, 2019
Within the cytoplasm of a single cell, several actin networks can coexist with distinct sizes, geometries, and protein compositions. These actin networks assemble in competition for a limited pool of proteins present in a common cellular environment.
Adrien Antkowiak, Audrey Guillotin, Micaela Boiero Sanders, Jessica Colombo, Renaud Vincentelli, Alphée Michelot   +5 more
doaj   +1 more source

Abiotic Stress-Induced Actin-Depolymerizing Factor 3 From Deschampsia antarctica Enhanced Cold Tolerance When Constitutively Expressed in Rice

Frontiers in Plant Science, 2021
The Antarctic flowering plant Deschampsia antarctica is highly sensitive to climate change and has shown rapid population increases during regional warming of the Antarctic Peninsula.
Mi Young Byun, Li Hua Cui, Li Hua Cui, Andosung Lee, Andosung Lee, Hyung Geun Oh, Hyung Geun Oh, Yo-Han Yoo, Jungeun Lee, Woo Taek Kim, Woo Taek Kim, Hyoungseok Lee, Hyoungseok Lee   +12 more
doaj   +1 more source

Cloning and characterization of actin depolymerizing factor from Toxoplasma gondii

Molecular and Biochemical Parasitology, 1997
We determined the predicted amino acid sequence of actin depolymerizing factor (ADF) from Toxoplasma gondii by sequencing the full-length cDNA. T. gondii ADF consists of 118 amino acids (calculated molecular weight 13,400) and shares a high degree of sequence similarity to other low molecular weight actin monomer sequestering proteins, especially ...
M L, Allen, J M, Dobrowolski, H, Muller, L D, Sibley, T E, Mansour   +4 more
openaire   +2 more sources

Social isolation suppresses actin dynamics and synaptic plasticity through ADF/cofilin inactivation in the developing rat barrel cortex

Scientific Reports, 2017
Exposure to a stressful environment early in life can cause psychiatric disorders by disrupting circuit formation. Actin plays central roles in regulating neuronal structure and protein trafficking.
Hirobumi Tada, Tomoyuki Miyazaki, Kiwamu Takemoto, Susumu Jitsuki, Waki Nakajima, Mayu Koide, Naoko Yamamoto, Akiko Taguchi, Honami Kawai, Kasane Komiya, Kumiko Suyama, Hiroki Abe, Akane Sano, Takuya Takahashi   +13 more
doaj   +1 more source

Cofilin and Actin Dynamics: Multiple Modes of Regulation and Their Impacts in Neuronal Development and Degeneration

Cells, 2021
Proteins of the actin depolymerizing factor (ADF)/cofilin family are ubiquitous among eukaryotes and are essential regulators of actin dynamics and function.
James R. Bamburg, Laurie S. Minamide, O’Neil Wiggan, Lubna H. Tahtamouni, Thomas B. Kuhn   +4 more
doaj   +1 more source

LIM kinase mediates estrogen action on the actin depolymerization factor Cofilin [PDF]

Brain Research, 2011
The ovarian hormone estrogen increases the axospinous synapse density in the hippocampal CA1 region of young female rats but fails to do so in aged rats. This estrogen-mediated alteration of spine synapse structures suggests the coincident requirement for the structural reorganization of the underlying actin cytoskeleton network.
Genevieve S, Yuen, Bruce S, McEwen, Keith T, Akama   +2 more
openaire   +2 more sources