Results 21 to 30 of about 178 (148)

Competition between Tropomyosin, Fimbrin, and ADF/Cofilin drives their sorting to distinct actin filament networks

eLife, 2017
The fission yeast actin cytoskeleton is an ideal, simplified system to investigate fundamental mechanisms behind cellular self-organization. By focusing on the stabilizing protein tropomyosin Cdc8, bundling protein fimbrin Fim1, and severing protein ...
Jenna R Christensen, Glen M Hocky, Kaitlin E Homa, Alisha N Morganthaler, Sarah E Hitchcock-DeGregori, Gregory A Voth, David R Kovar   +6 more
doaj   +1 more source

Coactosin-like 1 antagonizes cofilin to promote lamellipodial protrusion at the immune synapse. [PDF]

PLoS ONE, 2014
Actin depolymerizing factor-homology (ADF-H) family proteins regulate actin filament dynamics at multiple cellular locations. Herein, we have investigated the function of the ADF-H family member coactosin-like 1 (COTL1) in the regulation of actin ...
Joanna Kim, Michael J Shapiro, Adebowale O Bamidele, Pinar Gurel, Puspa Thapa, Henry N Higgs, Karen E Hedin, Virginia S Shapiro, Daniel D Billadeau   +8 more
doaj   +1 more source

Reactivation of Phosphorylated Actin Depolymerizing Factor and Identification of the Regulatory Site [PDF]

Journal of Biological Chemistry, 1995
Actin depolymerizing factor (ADF) occurs naturally in two forms, one of which contains a phosphorylated Ser and does not bind G-actin or depolymerize F-actin. Removal of this phosphate in vitro by alkaline phosphatase restores full F-actin depolymerizing activity.
B J, Agnew, L S, Minamide, J R, Bamburg
openaire   +2 more sources

Actin depolymerizing factor ADF7 inhibits actin bundling protein VILLIN1 to regulate root hair formation in response to osmotic stress in Arabidopsis.

PLoS Genetics, 2022
Actin cytoskeleton is essential for root hair formation. However, the underlying molecular mechanisms of actin dynamics in root hair formation in response to abiotic stress are largely undiscovered. Here, genetic analysis showed that actin-depolymerizing
Shuangtian Bi, Mingyang Li, Caiyuan Liu, Xiaoyu Liu, Jianing Cheng, Lu Wang, Jinshu Wang, Yanling Lv, Ming He, Xin Cheng, Yue Gao, Che Wang   +11 more
doaj   +1 more source

Interleukin-38 interacts with destrin/actin-depolymerizing factor in human keratinocytes.

PLoS ONE, 2019
Interleukin (IL)-38 is a member of the IL-1 family of cytokines, which was proposed to exert anti-inflammatory effects. IL-38 is constitutively expressed in the skin, where keratinocytes are the main producing cells.
Dominique Talabot-Ayer, Loïc Mermoud, Julia Borowczyk, Justyna Drukala, Michal Wolnicki, Ali Modarressi, Wolf-Henning Boehncke, Nicolo Brembilla, Gaby Palmer   +8 more
doaj   +1 more source

Autism-like Deficits in Shank3-Deficient Mice Are Rescued by Targeting Actin Regulators

Cell Reports, 2015
Haploinsufficiency of the Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses, is a highly prevalent and penetrant risk factor for autism.
Lara J. Duffney, Ping Zhong, Jing Wei, Emmanuel Matas, Jia Cheng, Luye Qin, Kaijie Ma, David M. Dietz, Yuji Kajiwara, Joseph D. Buxbaum, Zhen Yan   +10 more
doaj   +1 more source

The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies

Cell Reports, 2021
Summary: Cofilins are important for the regulation of the actin cytoskeleton, sarcomere organization, and force production. The role of cofilin-1, the non-muscle-specific isoform, in muscle function remains unclear.
Nicolas Vignier, Maria Chatzifrangkeskou, Luca Pinton, Hugo Wioland, Thibaut Marais, Mégane Lemaitre, Caroline Le Dour, Cécile Peccate, Déborah Cardoso, Alain Schmitt, Wei Wu, Maria-Grazia Biferi, Naïra Naouar, Coline Macquart, Maud Beuvin, Valérie Decostre, Gisèle Bonne, Guillaume Romet-Lemonne, Howard J. Worman, Francesco Saverio Tedesco, Antoine Jégou, Antoine Muchir   +21 more
doaj   +1 more source

Regulation of a Wheat Actin-Depolymerizing Factor during Cold Acclimation [PDF]

Plant Physiology, 2001
Abstract We have previously shown that the wheat (Triticum aestivum) TaADF gene expression level is correlated with the plants capacity to tolerate freezing. Sequence analysis revealed that this gene encodes a protein homologous to members of the actin-depolymerizing factor (ADF)/cofilin family.
F, Ouellet, E, Carpentier, M J, Cope, A F, Monroy, F, Sarhan   +4 more
openaire   +2 more sources

Arabidopsis ADF5 Acts as a Downstream Target Gene of CBFs in Response to Low-Temperature Stress

Frontiers in Cell and Developmental Biology, 2021
Low temperature is a major adverse environment that affects normal plant growth. Previous reports showed that the actin cytoskeleton plays an important role in the plant response to low-temperature stress, but the regulatory mechanism of the actin ...
Pan Zhang, Dong Qian, Changxin Luo, Yingzhi Niu, Tian Li, Chengying Li, Yun Xiang, Xinyu Wang, Yue Niu   +8 more
doaj   +1 more source

Genome-wide identification of actin-depolymerizing factor gene family and their expression patterns under various abiotic stresses in soybean (Glycine max)

Frontiers in Plant Science, 2023
The actin-depolymerizing factor (ADF) encoded by a family of genes is highly conserved among eukaryotes and plays critical roles in the various processes of plant growth, development, and stress responses via the remodeling of the architecture of the ...
Yongwang Sun, Deying Wang, Mengmeng Shi, Yujie Gong, Shuwen Yin, Yexuan Jiao, Shangjing Guo   +6 more
doaj   +1 more source