Results 81 to 90 of about 1,498,374 (404)

Actin Remodeling Defects Leading to Autoinflammation and Immune Dysregulation

Frontiers in Immunology, 2021
A growing number of monogenic immune-mediated diseases have been related to genes involved in pathways of actin cytoskeleton remodeling. Increasing evidences associate cytoskeleton defects to autoinflammatory diseases and primary immunodeficiencies.
Riccardo Papa, Federica Penco, Stefano Volpi, Marco Gattorno   +3 more
doaj   +1 more source

Transient Binding and Dissipation in Cross-Linked Actin Networks [PDF]

, 2008
In contrast with entangled actin solutions, transiently cross-linked actin networks can provide highly elastic properties while still allowing for local rearrangements in the microstructure-on biological relevant time scales.
Bausch, A.R., Claessens, M.M.A.E., Lieleg, O., Luan, Y.   +3 more
core   +4 more sources

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Cytoskeletons in the Closet—Subversion in Alphaherpesvirus Infections

Viruses, 2018
Actin filaments, microtubules and intermediate filaments form the cytoskeleton of vertebrate cells. Involved in maintaining cell integrity and structure, facilitating cargo and vesicle transport, remodelling surface structures and motility, the ...
Christopher E. Denes, Monica Miranda-Saksena, Anthony L. Cunningham, Russell J. Diefenbach   +3 more
doaj   +1 more source

Confinement Geometry Tunes Fascin-Actin Bundle Structures and Consequently the Shape of a Lipid Bilayer Vesicle

Frontiers in Molecular Biosciences, 2020
Depending on the physical and biochemical properties of actin-binding proteins, actin networks form different types of membrane protrusions at the cell periphery.
Yashar Bashirzadeh, Nadab H. Wubshet, Allen P. Liu, Allen P. Liu, Allen P. Liu, Allen P. Liu   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Actin/Spectrin Membrane-Associated Periodic Skeleton in Neurons

Frontiers in Synaptic Neuroscience, 2018
Neurons are the most asymmetric cell types, with their axons commonly extending over lengths that are thousand times longer than the diameter of the cell soma.
Nicolas Unsain, Nicolas Unsain, Nicolas Unsain, Fernando D. Stefani, Fernando D. Stefani, Alfredo Cáceres, Alfredo Cáceres, Alfredo Cáceres   +7 more
doaj   +1 more source

Molecular Model of the Contractile Ring

, 2005
We present a model for the actin contractile ring of adherent animal cells. The model suggests that the actin concentration within the ring and consequently the power that the ring exerts both increase during contraction.
D. Biron, D. Biron, D. Humphrey, D. H. Boal, E. Alvarez-Lacalle, E. Moses, I. Mabuchi, I. Mabuchi, J. Howard, O. Thoumine, R. Rappaport, R. L. Debiasio, T. Tlusty, T. D. Pollard, T. E. Schroeder, T. E. Schroeder   +15 more
core   +1 more source

Bem1p contributes to secretory pathway polarization through a direct interaction with Exo70p. [PDF]

, 2014
The exocyst serves to tether secretory vesicles to cortical sites specified by polarity determinants, in preparation for fusion with the plasma membrane.
Liu, Dongmei, Novick, Peter
core   +1 more source

Preconditioning of mesenchymal stromal cells with low-intensity ultrasound: influence on chondrogenesis and directed SOX9 signaling pathways [PDF]

, 2020
Background: Continuous low-intensity ultrasound (cLIUS) facilitates the chondrogenic differentiation of human mesenchymal stromal cells (MSCs) in the absence of exogenously added transforming growth factor-beta (TGFβ) by upregulating the expression of ...
A Argentaro, A Augello, A Katsumi, A Woods, A Woods, AD Miller, AH Huang, B Yang, BH Choi, C Huang, C Matta, CA Simmons, CB Little, CJ O’Conor, CY Huang, D Schumann, DR Haudenschild, EM Darling, F Dell'Accio, G Coricor, H Sim, H-C Hsu, HJ Kwon, HJ Lee, HJ Lee, J Li, J Puetzer, JC Sng, JD Kisiday, JH Cui, JH Cui, JW Choi, K Ebisawa, K Pelttari, L Bian, Li Ling, LJ Ng, M Shakibaei, M Tsuda, MA Corrigan, MB Mueller, N Fahy, N Thelin, NP Whitney, P Müller, R Ogawa, RL Mauck, RM Delaine-Smith, RS Tigli, S Murakami, S Noriega, S Noriega, S Yamaguchi, SD Cook, SD Cook, T Furumatsu, T Guo, T Ito, T Juhasz, T Nishida, T Sanjukta Guha, TM Louw, V Lefebvre, V Lefebvre, W Huang, W Huang, Z Li, ZJ Zhang   +67 more
core   +2 more sources