Results 61 to 70 of about 311,782 (303)

Effects of F/G-actin ratio and actin turn-over rate on NADPH oxidase activity in microglia

BMC Immunology, 2010
Background Most in vivo studies that have addressed the role of actin dynamics in NADPH oxidase function in phagocytes have used toxins to modulate the polymerization state of actin and mostly effects on actin has been evaluated by end point measurements
Rasmussen Izabela, Pedersen Line H, Byg Luise, Suzuki Kazuhiro, Sumimoto Hideki, Vilhardt Frederik   +5 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Interactions between plant endomembrane systems and the actin cytoskeleton

Frontiers in Plant Science, 2015
Membrane trafficking, organelle movement and morphogenesis in plant cells are mainly controlled by the cytoskeleton. Not all proteins that regulate the actin cytoskeleton and membrane dynamics in animal systems have functional homologues in plants ...
Pengwei eWang, Patrick J. Hussey
doaj   +1 more source

A novel function of twins, B subunit of protein phosphatase 2A, in regulating actin polymerization. [PDF]

PLoS ONE, 2017
Actin is an important component of the cytoskeleton and its polymerization is delicately regulated by several kinases and phosphatases. Heterotrimeric protein phosphatase 2A (PP2A) is a potent phosphatase that is crucial for cell proliferation, apoptosis,
Po-An Yeh, Ching-Jin Chang
doaj   +1 more source

Molecular characterisation of human penile carcinoma and generation of paired epithelial primary cell lines

Molecular Oncology, EarlyView.
Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad, Mahmood Hachim, Tom Bertin, Karolina Penderecka, Rifat Hamoudi, Saif Khan, Rui Henrique, Natalie Bergmoser, Manit Arya, Kalle Sipila, Matteo Vietri Rudan, Asif Muneer, Aamir Ahmed   +12 more
wiley   +1 more source

Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]

, 2018
BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna, Gao, Yuan, Leavis, Paul, Li, Qian, Mitchell, G. F., Morgan, Kathleen, Nicholson, Christopher, Porter, Tyrone, Saphirstein, Robert, Singh, Kuldeep, Verwoert, Germaine   +10 more
core   +1 more source

In vivo reorganization of the actin cytoskeleton in leaves of Nicotiana tabacum L. transformed with plastin-GFP. Correlation with light-activated chloroplast responses

BMC Plant Biology, 2009
Background The actin cytoskeleton is involved in the responses of plants to environmental signals. Actin bundles play the role of tracks in chloroplast movements activated by light.
Anielska-Mazur Anna, Bernaś Tytus, Gabryś Halina   +2 more
doaj   +1 more source

Oxidation and reduction of actin: Origin, impact in vitro and functional consequences in vivo

European Journal of Cell Biology, 2022
Actin is among the most abundant proteins in eukaryotic cells and assembles into dynamic filamentous networks regulated by many actin binding proteins. The actin cytoskeleton must be finely tuned, both in space and time, to fulfill key cellular functions
Clémentine Rouyère, Thomas Serrano, Stéphane Frémont, Arnaud Echard   +3 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Microvibration stimuli causes localized depolymerization of the actin cytoskeleton of osteoblasts around the nucleus

Journal of Biomechanical Science and Engineering
Reports have indicated that microvibration stimulation activates bone remodeling and promotes bone formation. However, the mechanism by which microvibration stimulation facilitates bone formation remains incompletely understood, and it is unclear how ...
Katsuya SATO, Satoshi ODA
doaj   +1 more source