Results 101 to 110 of about 243,847 (379)
Large scale analysis of protein stability in OMIM disease related human protein variants [PDF]
, 2016 Modern genomic techniques allow to associate several Mendelian human diseases to single residue variations in different proteins. Molecular mechanisms explaining the relationship among genotype and phenotype are still under debate.
Aggazio, Francesco +5 more
core +3 more sources
Mechanisms of Development, 2003 1. From molecules to morphologyMetazoan development is often viewed as a series ofinformation processing events in which the genomecomputes where and when to synthesize particular geneproducts. Importantly, development is also a feat ofengineering in which genetic information is used to changecell shape and cell–cell interactions to generate form ...
Jacinto, Antonio, Baum, Buzz
openaire +2 more sources
Inhibition of CDK9 enhances AML cell death induced by combined venetoclax and azacitidine
Molecular Oncology, EarlyView.The CDK9 inhibitor AZD4573 downregulates c‐MYC and MCL‐1 to induce death of cytarabine (AraC)‐resistant AML cells. This enhances VEN + AZA‐induced cell death significantly more than any combination of two of the three drugs in AraC‐resistant AML cells.
Shuangshuang Wu +18 more
wiley +1 more source
Nature Communications, 2018 In the mdx mouse model of Duchenne muscular dystrophy, muscle contractions lead to force loss, which is attributed to myofibre damage. Here, the authors show that force loss is instead mediated by a redox circuit involving NOX2, PROX1, myoglobin and ...
John T. Olthoff +11 more
doaj +1 more source
Geometric pumping induced by shear flow in dilute liquid crystalline polymer solutions [PDF]
, 2014 We investigate nonlinear rheology of dilute liquid crystalline polymer solutions under time dependent two-directional shear flow. We analyze the Smoluchowski equation, which describes the dynamics of the orientation of a liquid crystalline polymer, by ...
de Gennes P. G. +4 more
core +2 more sources
A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
An Immunodominant Membrane Protein (Imp) of ‘Candidatus Phytoplasma mali’ Binds to Plant Actin
Molecular Plant-Microbe Interactions, 2012 The phytopathogenic, cell-wall-less phytoplasmas exhibit a dual life cycle: they multiply in the phloem of their host plant and in the body of their insect vector.
K. Boonrod +4 more
doaj +1 more source
Vimentin downregulation is an inherent feature of murine erythropoiesis and occurs independently of lineage [PDF]
, 1990 In mammalian erythropoiesis, the mature cells of the primitive lineage remain nucleated while those of the definitive lineage are anuclear. One of the molecular and structural changes that precedes enucleation in cells of the definitive lineage is the ...
Lazarides, Elias +2 more
core
Molecular Oncology, EarlyView.Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié +16 more
wiley +1 more source
Phagocytosis of full-length Tau oligomers by Actin-remodeling of activated microglia [PDF]
, 2020 Rashmi Ranjan Das +2 more
openalex +1 more source