Results 41 to 50 of about 243,847 (379)

Actin isoforms and neoplastic transformation

open access: yesУспехи молекулярной онкологии, 2017
The cytoplasmic actins (β and γ) play crucial roles during key cellular processes like adhesion, migration, polarization and cytokinesis. The understanding of their specific underlying mechanisms would be of major relevance not only for fundamental ...
V. B. Dugina   +3 more
doaj   +1 more source

Novel Actin Cytoskeleton. Actin Tubules.

open access: yesCell Structure and Function, 2000
In spores of Dictyostelium discoideum three actin filaments are bundled to form a novel tubular structure and the tubules are then organized into rods. These tubular structures we will term actin tubules. Actin tubules are reconstructed from the supernatant of spore homogenates, while the usual actin filaments were bundled after incubation of ...
M, Sameshima   +4 more
openaire   +3 more sources

Molecular characterization of three muscle alpha actin genes in mud loach (Misgurnus mizolepis; Cypriniformes)

open access: yesFisheries and Aquatic Sciences, 2017
Background Teleosts represent unique features in the regulation of muscle development and growth, with a great deal of myogenic plasticity. Muscle actins are major components to compose muscle fibers, and they play essential roles in cellular mobility ...
Sang Yoon Lee   +2 more
doaj   +1 more source

Stability domains of actin genes and genomic evolution

open access: yes, 2007
In eukaryotic genes the protein coding sequence is split into several fragments, the exons, separated by non-coding DNA stretches, the introns. Prokaryotes do not have introns in their genome.
A. Dkhissi   +9 more
core   +1 more source

Relative importance of βcyto- and γcyto-actin in primary mouse embryonic fibroblasts [PDF]

open access: yes, 2017
The highly homologous β (βcyto) and γ (γcyto) cytoplasmic actins are hypothesized to carry out both redundant and unique essential functions, but studies using targeted gene knockout and siRNA-mediated transcript knockdown to examine βcyto- and γcyto ...
Chamberlain, Christopher M.   +5 more
core   +1 more source

The Actin Cytoskeleton and Actin-Based Motility [PDF]

open access: yesCold Spring Harbor Perspectives in Biology, 2018
The actin cytoskeleton-a collection of actin filaments with their accessory and regulatory proteins-is the primary force-generating machinery in the cell. It can produce pushing (protrusive) forces through coordinated polymerization of multiple actin filaments or pulling (contractile) forces through sliding actin filaments along bipolar filaments of ...
openaire   +2 more sources

Monoclonal antibodies against muscle actin isoforms: epitope identification and analysis of isoform expression by immunoblot and immunostaining in normal and regenerating skeletal muscle [version 2; referees: 3 approved]

open access: yesF1000Research, 2016
Higher vertebrates (mammals and birds) express six different highly conserved actin isoforms that can be classified in three subgroups: 1) sarcomeric actins, α-skeletal (α-SKA) and α-cardiac (α-CAA), 2) smooth muscle actins (SMAs), α-SMA and γ-SMA, and 3)
Christine Chaponnier, Giulio Gabbiani
doaj   +1 more source

Collective force generated by multiple biofilaments can exceed the sum of forces due to individual ones

open access: yes, 2014
Collective dynamics and force generation by cytoskeletal filaments are crucial in many cellular processes. Investigating growth dynamics of a bundle of N independent cytoskeletal filaments pushing against a wall, we show that chemical switching (ATP/GTP ...
Das, Dibyendu   +2 more
core   +2 more sources

Rapid production of pure recombinant actin isoforms in Pichia pastoris [PDF]

open access: yes, 2018
Actins are major eukaryotic cytoskeletal proteins, which perform many important cell functions, including cell division, cell polarity, wound healing, and muscle contraction.
Alioto, Salvatore   +15 more
core   +1 more source

Rapid Nucleotide Exchange Renders Asp-11 Mutant Actins Resistant to Depolymerizing Activity of Cofilin, Leading to Dominant Toxicity in Vivo*

open access: yesJournal of Biological Chemistry, 2012
Background: Mutation of Asp-11 is dominant negative in yeast and human actins. Results: Mutant actins exchange bound nucleotides rapidly, cannot bind cofilin, and cofilin-induced depolymerization of mutant and wild type copolymers is slow.
N. Umeki   +7 more
semanticscholar   +1 more source

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