Frontiers in Bioscience-LandmarkBackground: Lung cancer is the primary cause of cancer-related mortality, but the molecular mechanisms behind this malignancy remain unclear.
Yao Li +9 more
doaj +1 more source
Dendritic Actin Filament Nucleation Causes Traveling Waves and Patches [PDF]
, 2010 The polymerization of actin via branching at a cell membrane containing nucleation-promoting factors is simulated using a stochastic-growth methodology. The polymerized-actin distribution displays three types of behavior: a) traveling waves, b) moving patches, and c) random fluctuations.
arxiv +1 more source
Resident phenotypically modulated vascular smooth muscle cells in healthy human arteries. [PDF]
, 2012 Vascular interstitial cells (VICs) are non-contractile cells with filopodia previously described in healthy blood vessels of rodents and their function remains unknown.
Greenwood, IA +10 more
core +1 more source
Concanavalin A-induced cap formation in rat ascites hepatoma cells (AH 7974) and the interaction of cytoplasmic proteins with plasma membranes. [PDF]
, 1987 Concanavalin A (Con A) induced cap formation in rat ascites hepatoma cells (AH7974). In these Con A-treated cells, the association of cytoplasmic proteins with cell membranes was suggested by observing their Triton shells.
Moromizato, Yasunori +2 more
core +1 more source
ATP hydrolysis stimulates large length fluctuations in single actin filaments [PDF]
, 2005 Polymerization dynamics of single actin filaments is investigated theoretically using a stochastic model that takes into account the hydrolysis of ATP-actin subunits, the geometry of actin filament tips, the lateral interactions between the monomers as well as the processes at both ends of the polymer.
arxiv +1 more source
Transformation from spots to waves in a model of actin pattern formation [PDF]
Phys. Rev. Lett. 102, 198103 (2009), 2008 Actin networks in certain single-celled organisms exhibit a complex pattern-forming dynamics that starts with the appearance of static spots of actin on the cell cortex. Spots soon become mobile, executing persistent random walks, and eventually give rise to traveling waves of actin.
arxiv +1 more source
Actin dynamics: Assembly and disassembly of actin networks [PDF]
Current Biology, 2000 Assembly of branched actin filament networks at the leading edge of migrating cells requires stimulation of the Arp2/3 complex by WASp proteins, in concert with the WASp activators Cdc42, PIP(2) and profilin. Network disassembly and debranching appears to be linked to actin-bound ATP hydrolysis as filaments age.
Martin A. Wear +2 more
openaire +3 more sources
Computational model combined with in vitro experiments to analyse mechanotransduction during mesenchymal stem cell adhesion. [PDF]
, 2013 The shape that stem cells reach at the end of adhesion process influences their differentiation. Rearrangement of cytoskeleton and modification of intracellular tension may activate mechanotransduction pathways controlling cell commitment.
D Heymann +8 more
core +5 more sources
Conservation of conformational dynamics across prokaryotic actins.
PLoS Computational Biology, 2019 The actin family of cytoskeletal proteins is essential to the physiology of virtually all archaea, bacteria, and eukaryotes. While X-ray crystallography and electron microscopy have revealed structural homologies among actin-family proteins, these ...
Natalie Ng +3 more
doaj +1 more source
The origins of phagocytosis and eukaryogenesis
Biology Direct, 2009 Background Phagocytosis, that is, engulfment of large particles by eukaryotic cells, is found in diverse organisms and is often thought to be central to the very origin of the eukaryotic cell, in particular, for the acquisition of bacterial endosymbionts
Wolf Yuri I +3 more
doaj +1 more source