Results 71 to 80 of about 16,783,083 (225)

HOXA10 controls osteoblastogenesis by directly activating bone regulatory and phenotypic genes [PDF]

, 2007
HOXA10 is necessary for embryonic patterning of skeletal elements, but its function in bone formation beyond this early developmental stage is unknown. Here we show that HOXA10 contributes to osteogenic lineage determination through activation of Runx2 ...
van Wijnen, AJ, Stein, JL, Lee, SH, Montecino, M, Montecino, Martin A., Lian, JB, Lee, Suk Hee, Stein, Janet L., Hassan, MQ, Van Wijnen, Andre J., Mandeville, Matthew, Mandeville, M, Weiner, B, Weiner, Brian, Lian, Jane B., Stein, GS, Tare, Rahul S., Tare, R., Hassan, Mohammad Q., Stein, Gary S.   +19 more
core   +1 more source

An Integrative Strategy Delineates Modular Metabolic Remodeling and Potential Therapeutic Targets Across Metabolic Diseases

Advanced Science, EarlyView.
An integrative single‐cell atlas across multiple metabolic diseases reveals coordinated metabolic modules and disease‐shared versus disease‐specific pathway activities. By systematically comparing scoring strategies, a robust RankAve framework is established. Coupled with network analysis and drug‐target prediction, this resource uncovers cross‐disease
Kuan Yang, Congxue Hu, Hang Zhao, Xiao Peng, Yiming Yan, Jiasi Wang, Wenqi Jiang, Depeng Mu, Yan Cao, Xia Li, Yunpeng Zhang   +10 more
wiley   +1 more source

Molecular and Cellular Hallmarks of Age‐Related Vestibular Hair Cell Degeneration

Advanced Science, EarlyView.
This study utilizes single‐cell RNA‐seq transcriptomes, advanced imaging, and electrophysiology to examine universal and cell‐type‐specific aging signatures of vestibular hair cells. The study shows that impaired hair bundle function is a key driver of age‐related vestibular dysfunction.
Samadhi Kulasooriya, Huizhan Liu, Sarath Vijayakumar, Celia Bloom, Zhenhang Xu, Shu Tu, Benjamin J. Borgmeier, Mi Zhou, Litao Tao, Bechara Kachar, David Z. He   +10 more
wiley   +1 more source

Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to maternal nutrition [PDF]

British Journal of Nutrition, 2015
The aim of the present study was to investigate the mechanistic basis of protein deficiency during pregnancy in mother that is transduced to offspring. To this end, timed-pregnant Sprague–Dawley rats were fed either a control (20 % of energy from protein) or low-protein (LP, 8 % of energy from protein) diet during gestation.
Huan, Wang, Gabriel J, Wilson, Dan, Zhou, Stéphane, Lezmi, Xiuwen, Chen, Donald K, Layman, Yuan-Xiang, Pan   +6 more
openaire   +2 more sources

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

Loss of Activating Transcription Factor 4 (ATF4) Alters the Homeostatic Amino Acid Response (AAR) in the Liver of Mice Treated with Asparaginase

The FASEB Journal, 2015
L‐asparaginase (ASNase) is widely used to treat leukemia in children but it causes metabolic complications and liver toxicity. ASNase activates the amino acid response (AAR), increasing gene‐specific translation of the transcription factor ATF4 to regain homeostasis via altered gene expression.
Rana Al‐Baghdadi, Emily Mirek, Lindsey Phillipson‐Weiner, William Belden, Ronald Wek, Tracy Anthony   +5 more
openaire   +1 more source

Aberrant GRP78 Phase Transition Sustains Endothelial IRE1α Signaling and Drives Blood–Brain Barrier Failure in Cerebral Amyloid Angiopathy

Advanced Science, EarlyView.
Vascular Aβ40 corrupts GRP78 phase behavior in brain endothelial cells, sustaining IRE1α–TRAF2–JNK signaling and driving apoptosis, tight junction loss, and blood–brain barrier failure in cerebral amyloid angiopathy. Pharmacological IRE1α inhibition restores vascular integrity, reduces leakage, and improves functional outcomes, revealing a targetable ...
Honglin Zheng, Qiang Li, Haiyang Luo, Yapei Yuan, Na Zhang, Yongting Lu, Suying Duan, Jieshi Zhong, Hang Zhang, Chenyang Liu, Yaochong Zhang, Wenzhuo Zhao, Yaxuan Song, Tuo Wang, Si Yan, Yapeng Li, Han Liu, Yuan Gao, Zongping Xia, Yuming Xu   +19 more
wiley   +1 more source

The basic helix loop helix transcription factor twist1 is a novel regulator of ATF4 in osteoblasts [PDF]

, 2011
Parathyroid hormone (PTH) is an essential regulator of endochondral bone formation and an important anabolic agent for the reversal of bone loss. PTH mediates its functions in part by regulating binding of the bone‐related activating transcription factor
Franceschi, Renny T., Renny T. Franceschi, Li, Yan, Theodora E. Danciu, Laurie K. McCauley, Xiao, Guozhi, Danciu, Theodora E., Koh, Amy J., McCauley, Laurie K., Guozhi Xiao, Yan Li, Amy Koh   +11 more
core   +1 more source

Functional interaction of the subunit 3 of RNA Polymerase II (RPB3) with transcription factor-4 (ATF4) [PDF]

, 2003
RPB3 is a core subunit of RNA polymerase II (pol II) that, together with the RPB11 subunit, forms the heterodimer considered as a functional counterpart of the bacterial alpha subunit homodimer involved in promoter recognition. We previously employed the
Di Padova M, Bruno T, Passananti C, De Angelis R Iezzi S, Fanciulli M, Corbi N, Floridi A   +6 more
core   +2 more sources

Heregulin induces expression, DNA binding activity and transactivating functions of basic leucine zipper activating transcription factor 4 [PDF]

, 2000
Heregulin β1 (HRG), a combinatorial ligand for human epidermal growth factor receptor 3 and human epidermal growth factor receptor 4 receptors, is a regulatory secretory polypeptide with distinct biological effects such as growth stimulation ...
Kumar, Rakesh, Talukder, Amjad H., Vadlamudi, Ratna, Mandal, Mahitosh   +3 more
core   +2 more sources