Results 31 to 40 of about 211,322 (248)
Frontiers in Immunology, 2012 The predominant expression of the γ and δ isoforms of PI3K in cells of hematopoietic lineage prompted speculation that inhibitors of these isoforms could offer opportunities for selective targeting of PI3K in the immune system in a range of immune ...
Stephen Geoffrey Ward +1 more
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Conditions of formation and stimulation of the activators of innovative development of Ukraine [PDF]
Problems and Perspectives in Management, 2017 Western analysts are still pessimistic about the prospects of technological (innovative) business in Eastern Europe. Not only unsatisfactory domestic economic processes, but also the current global economic structural and industrial transformations are ...
Iryna Shtuler +3 more
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Virtual Screening in the Identification of Sirtuins’ Activity Modulators
Molecules, 2022 Sirtuins are NAD+-dependent deac(et)ylases with different subcellular localization. The sirtuins’ family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins
Elena Abbotto +5 more
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Journal of Enzyme Inhibition and Medicinal Chemistry, 2018 The α- and β-class carbonic anhydrases (CAs, EC 4.2.1.1) from the pathogenic bacterium Vibrio cholerae, VchCAα, and VchCAβ, were investigated for their activation with natural and non-natural amino acids and amines.
Andrea Angeli +7 more
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Insights on the Modulation of SIRT5 Activity: A Challenging Balance
Molecules, 2022 SIRT5 is a member of the Sirtuin family, a class of deacetylating enzymes consisting of seven isoforms, involved in the regulation of several processes, including gene expression, metabolism, stress response, and aging.
Matteo Mori +4 more
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Frontiers in Plant Science, 2021 The alternative oxidase (AOX) is widespread in plants, fungi, and some protozoa. While the general structure of the AOX remains consistent, its overall activity, sources of kinetic activation and their sensitivity to inhibitors varies between species. In
Fei Xu +5 more
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Activate, Inactive, Activity. [PDF]
, 2021 <p>Sports facilities in the Central Wellington area cater to physical activity for only a select portion of the population. Most of the time use is determined by the posts at each end of the field. Through the process of design research, I will test ways of maximizing space which is not used in thesefacilities to bring more physical and ...
openaire +1 more source
BK channel activators and their therapeutic perspectives
Frontiers in Physiology, 2014 The large conductance calcium- and voltage- activated K+ channel (KCa1.1, BK, MaxiK) is ubiquitously expressed in the body, and holds the ability to integrate changes in intracellular calcium and membrane potential. This makes the BK channel an important
Bo Hjorth Bentzen +5 more
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Frontiers in Molecular Neuroscience, 2022 Hemorrhagic stroke can be categorized into several subtypes. The most common is intracerebral hemorrhage (ICH), which exhibits significant morbidity and mortality, affecting the lives of millions of people worldwide every year.
Yuan Zhang +5 more
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Applying Biostimulants to Combat Water Deficit in Crop Plants: Research and Debate
Agronomy, 2022 Climate change has increased the severity of drought episodes by further reducing precipitation in vulnerable zones. Drought induces a substantial decrease in agricultural water, reducing crop yields.
David Jiménez-Arias +6 more
doaj +1 more source