Results 101 to 110 of about 73,976 (284)

Generation of an expandable intermediate mesoderm restricted progenitor cell line from human pluripotent stem cells. [PDF]

, 2015
The field of tissue engineering entered a new era with the development of human pluripotent stem cells (hPSCs), which are capable of unlimited expansion whilst retaining the potential to differentiate into all mature cell populations.
Brafman, David, Bush, Kevin T, Cutts, Josh, Gaasterland, Terry, Kumar, Nathan, Nigam, Sanjay K, Richter, Jenna, Trujillo, Cleber, Willert, Karl   +8 more
core   +3 more sources

Activin Regulates  A-Subunit and Activin Receptor Messenger Ribonucleic Acid and Cellular Proliferation in Activin-Responsive Testicular Tumor Cells [PDF]

Endocrinology, 1998
Activin, a member of the transforming growth factor-beta superfamily of growth and differentiation factors, has a number of actions in embryonic as well as adult tissues. These actions are mediated via a family of receptors containing two subtypes and at least two members of each subtype.
Di Simone, Nicoletta, Hall Ha, Welt C, Schneyer Al   +3 more
openaire   +2 more sources

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Role for TGF-beta superfamily signaling in telencephalic GABAergic neuron development. [PDF]

, 2010
Signaling mechanisms mediated by the Transforming Growth Factor-beta (TGF-beta) superfamily regulate a variety of developmental processes. Here we show that components of both bone morphogenetic protein/growth differentiation factor and TGF-beta/activin ...
Lee, Amie Y, Long, Jason E, Maira, Mario, Rubenstein, John LR, Stifani, Stefano   +4 more
core  

Roles of binding elements, FOXL2 domains, and interactions with cJUN and SMADs in regulation of FSHβ. [PDF]

, 2014
We previously identified FOXL2 as a critical component in FSHβ gene transcription. Here, we show that mice deficient in FOXL2 have lower levels of gonadotropin gene expression and fewer LH- and FSH-containing cells, but the same level of other pituitary ...
Barakat, Nermeen H, Breen, Kellie M, Coss, Djurdjica, Hambarchyan, Arpi, Meadows, Jason D, Mellon, Pamela L, Pepa, Patricia A, Roybal, Lacey L   +7 more
core   +1 more source

Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy

Science Translational Medicine, 2018
Inhibition of activin signaling enhances the efficacy and safety of platinum chemotherapy in lung adenocarcinoma models. Blocking activin actively treats cancer Platinum-based chemotherapy is a mainstay of treatment for lung cancer, but resistance to ...
Kieren D Marini, David R. Croucher, R. McCloy, Vijesh Vaghjiani, A. Gonzalez-Rajal, Jordan F Hastings, V. Chin, A. Szczepny, K. Kostyrko, César P. Márquez, W. Jayasekara, Muhammad Alamgeer, V. Boolell, Jeremy Z. R. Han, Todd Waugh, Hong Ching Lee, Samantha R. Oakes, B. Kumar, Craig A. Harrison, M. Hedger, Nirmal Lorensuhewa, Badia Kita, Ross Barrow, Bruce W. Robinson, D. D. de Kretser, Jianmin Wu, V. Ganju, E. Sweet-Cordero, A. Burgess, L. Martelotto, Fernando J. Rossello, Jason E. Cain, D. N. Watkins   +32 more
semanticscholar   +1 more source

The Expansion of Heterotopic Bone in Fibrodysplasia Ossificans Progressiva Is Activin A‐Dependent

Journal of Bone and Mineral Research, 2017
Fibrodysplasia ossificans progressiva (FOP) is a rare autosomal dominant disorder that is characterized by episodic yet cumulative heterotopic ossification (HO) in skeletal muscles, tendons, and ligaments over a patient's lifetime.
J. Upadhyay, Liqin Xie, Lily Huang, Nanditha Das, R. C. Stewart, Morgan C Lyon, Keryn Palmer, Saathyaki Rajamani, Chris Graul, Merryl Lobo, Tyler J Wellman, Edward J. Soares, Matthew D. Silva, J. Hesterman, Lili Wang, Xialing Wen, Xiaobing Qian, Kalyan C. Nannuru, V. Idone, A. Murphy, A. Economides, S. Hatsell   +21 more
semanticscholar   +1 more source

Acute Modulation of Synaptic Plasticity of Pyramidal Neurons by Activin in Adult Hippocampus

Frontiers in Neural Circuits, 2014
Activin A is known as a neuroprotective factor produced upon acute excitotoxic injury of the hippocampus (in pathological states). We attempt to reveal the role of activin as a neuromodulator in the adult male hippocampus under physiological conditions ...
Yoshitaka eHasegawa, Hideo eMukai, Hideo eMukai, Hideo eMukai, Hideo eMukai, Makoto eAsashima, Yasushi eHojo, Yasushi eHojo, Yasushi eHojo, Muneki eIkeda, Yoshimasa eKomatsuzaki, Yuuki eOoishi, Suguru eKawato, Suguru eKawato, Suguru eKawato, Suguru eKawato   +15 more
doaj   +1 more source

Activin a suppresses peripheral CD8+ T lymphocyte activity in acute-phase Kawasaki disease

BMC Immunology, 2021
Background Kawasaki disease is an autoimmune disease characterized by systemic vasculitis of unknown aetiology and most commonly occurs in children under 5 years old.
Qian Wu, Ruohang Weng, Yongbin Xu, Linlin Wang, Yanyan Huang, Jun Yang   +5 more
doaj   +1 more source

Activin A and activin receptors in gestational tissue from preeclamptic pregnancies [PDF]

Journal of Endocrinology, 2001
Maternal serum activin A levels are elevated in women with preeclampsia. To explore whether this could be due, at least in part, to increased production by the gestational tissues, we have measured activin A in the serum of women with (n=23) or without preeclampsia (n=62) at 29-40 weeks of gestation and in placenta and fetal membranes from preterm ...
U, Manuelpillai, M, Schneider-Kolsky, A, Dole, E M, Wallace   +3 more
openaire   +2 more sources