Results 111 to 120 of about 73,976 (284)
Gut and LiverBackground/Aims: Cancer stem cells (CSCs) are believed to drive tumor development and metastasis. Activin and hepatocyte growth factor (HGF) are important cytokines with the ability to induce cancer stemness.
Hong Peng +6 more
doaj +1 more source
A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling
Cellular & Molecular Biology Letters, 2023 Background TGFβ1 is a major profibrotic mediator in chronic kidney disease (CKD). Its direct inhibition, however, is limited by adverse effects. Inhibition of activins, also members of the TGFβ superfamily, blocks TGFβ1 profibrotic effects, but the ...
Asfia Soomro +8 more
doaj +1 more source
The specificities of small molecule inhibitors of the TGF beta and BMP pathways [PDF]
, 2011 Small molecule inhibitors of type 1 receptor serine threonine kinases (ALKs1-7), the mediators of TGF beta and BMP signals, have been employed extensively to assess their physiological roles in cells and organisms. While all of these inhibitors have been
Sapkota, Gopal P. +2 more
core +3 more sources
An Activin-A/C Chimera Exhibits Activin and Myostatin Antagonistic Properties [PDF]
Journal of Biological Chemistry, 2005 Activins are involved in many physiological and pathological processes and, like other members of the transforming growth factor-beta superfamily, signal via type II and I receptor serine kinases. Ligand residues involved in type II receptor binding are located in the two anti-parallel beta strands of the TGF-beta proteins, also known as the fingers ...
Uwe, Muenster +4 more
openaire +2 more sources
Journal of Biological Chemistry, 2017 Bone and skeletal muscle mass are highly correlated in mammals, suggesting the existence of common anabolic signaling networks that coordinate the development of these two anatomically adjacent tissues.
B. Goh +9 more
semanticscholar +1 more source
Somatic cell reprogramming for Parkinson's disease treatment
Ibrain, Volume 11, Issue 1, Page 59-73, Spring 2025.The fundamental purpose of cell reprogramming to treat Parkinson's disease is to generate dopaminergic neurons (DAN) and do transplantation. There are two ways to accomplish this. One method is to induce cells into induced DA neurons (iDAN) directly or to induce cells into induced pluripotent stem cells and ultimately into iDAN in vitro. Another option
Xiaozhuo Li, Kevin Fang, Fengping Wang
wiley +1 more source
Functional Analysis of Mature Activin A Produced by Enterokinase in Plant Cells
RiceMolecular farming for producing biopharmaceuticals in plants is considered an excellent method to replace some of the production methods currently used, and a significant number of recombinant proteins have already shown the potential to facilitate this.
Ki-Beom Moon +7 more
doaj +1 more source
Endometrial Stromal Cell Senescence: A Non‐Negligible Factor in Recurrent Pregnancy Loss
iMetaMed, EarlyView.As populations age, links between female reproductive aging and infertility are increasingly evident. Cellular senescence, characterized by near‐irreversible cell‐cycle arrest and accumulation of damage, can impair tissue function. In the endometrium, aberrant senescence of endometrial stromal cells (EnSCs) may compromise receptivity, hinder embryo ...
Shuang Wu +6 more
wiley +1 more source
Scientific ReportsActivin A and hepatic stellate cells (HSCs) are involved in tissue repair and fibrosis in liver injury. This study investigated the impact of activin A on HSC activation and migration.
Wei Zhang +7 more
doaj +1 more source
Activin A programs human TFH cell differentiation
Nature Immunology, 2016 Follicular helper T cells (TFH cells) are CD4+ T cells specialized in helping B cells and are associated both with protective antibody responses and autoimmune diseases.
M. Locci +6 more
semanticscholar +1 more source